A novel synthetic derivative of the natural product berbamine inhibits cell viability and induces apoptosis of human osteosarcoma cells, associatedwith activation of JNK/AP-1 signaling

Cancer Biology and Therapy

Volumn 14, Issue 11, 2013, Pages 1024-1031

  Yang, Fan ^a   Nam, Sangkil ^a   Zhao, Robin ^a   Tian, Yan ^a   Liu, Lucy ^a   Horne, David A ^a   Jove, Richard ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

AP 1; Apoptosis; Berbamine derivative; JNK; Natural product; Osteosarcoma

Indexed keywords

ACETYLCYSTEINE; BERBAMINE; BERBAMINE DERIVATIVE 3; CASPASE 3; CYCLIN D1; CYCLIN D2; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; PROTEIN BAD; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL GROWTH; CELL LYSATE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; ONCOGENE C FOS; OSTEOSARCOMA CELL; OXIDATIVE STRESS; PROTEIN CLEAVAGE; STAINING; UPREGULATION;

AP-1; APOPTOSIS; BERBAMINE DERIVATIVE; JNK; NATURAL PRODUCT; OSTEOSARCOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZYLISOQUINOLINES; BONE NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; CYCLIN D1; CYCLIN D2; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOSARCOMA; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 84890241488     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.26045     Document Type: Article

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