MiR-942 mediates hepatitis C virus-induced apoptosis via regulation of ISG12a

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Yang, Darong ^a   Meng, Xianghe ^a   Xue, Binbin ^a   Liu, Nianli ^a   Wang, Xiaohong ^a   Zhu, Haizhen ^a,b  

^a HUNAN UNIVERSITY   (China)

^b HUNAN CANCER HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON STIMULATED GENE12A; MICRORNA; MICRORNA 942; NONSTRUCTURAL PROTEIN 5A; PROTEIN NOXA; RETINOIC ACID INDUCIBLE PROTEIN I; RNA ANTIBODY; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; VIRUS RNA; DDX58 PROTEIN, HUMAN; DEAD BOX PROTEIN; IFI27 PROTEIN, HUMAN; IRF3 PROTEIN, HUMAN; MEMBRANE PROTEIN; MIRN942 MICRORNA, HUMAN; PMAIP1 PROTEIN, HUMAN; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; BIOINFORMATICS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; GENE; GENE CONTROL; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENE SILENCING; GENE TARGETING; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INNATE IMMUNITY; IRF3 GENE; ISG12A GENE; LIVER CELL; NONHUMAN; PREDICTIVE VALUE; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; RIG 1 GENE; RNA GENE; TRAIL GENE; UPREGULATION; VIRUS CELL INTERACTION; VIRUS ISOLATION; DRUG EFFECTS; GENETICS; HEPACIVIRUS; ISOLATION AND PURIFICATION; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; VIROLOGY;

APOPTOSIS; CELL LINE, TUMOR; DEAD-BOX RNA HELICASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; INTERFERON REGULATORY FACTOR-3; INTERFERON-BETA; MALE; MEMBRANE PROTEINS; MICRORNAS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84899624306     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094501     Document Type: Article

References (35)

1. McHutchison JG (2004) Understanding hepatitis C. Am J Manag. Care 10(2 Suppl): S21-S29. (Pubitemid 38380782)
2. Lavanchy D (2009) The global burden of hepatitis C. Liver Int 29(suppl. 1):74-81.
3. Leung DW, Basler CF, Amarasinghe GK (2012) Molecular mechanisms of viral inhibitors of RIG-I-like receptors. Trends Microbiol 20: 139-146.
4. Arpaia N, Barton GM (2011) Toll-like receptors: key players in antiviral activity. Curr Opin Virol 1: 447-454.
5. Zhu H, Zhao H, Collins CD, Eckerrode SE, Ruan Q, et al. (2003) Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line. Hepatology 37: 1180-1188. (Pubitemid 36538696)
6. Uzri D, Gehrke L (2009) Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities. J Virol 83: 4174-4184.
7. Ramanathan A, Miller MT, Tang GQ, Gale M Jr, Patel SS, et al. (2011) Structural basis of RNA recognition and activation by innate immune receptor RIG-I. Nature 479: 423-427.
8. Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale M Jr (2008) Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature 454: 523-527.
9. Lindenbach BD, Evans MJ, Syder AJ, Wolk B, Tellinghuisen TL, et al. (2005) Complete replication of hepatitis C virus in cell culture. Science 309: 623-626. (Pubitemid 41033648)
10. Wakita T, Pietschmann T, Kato T, Date T, Miyamoto M, et al. (2005) Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med 11: 791-796. (Pubitemid 41021213)
11. Zhong J, Gastaminza P, Cheng G, Kapadia S, Kato T, et al. (2005) Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci USA 102: 9294-9299. (Pubitemid 40923557)
12. Sumpter R Jr, Loo YM, Foy E, Li K, Yoneyama M, et al. (2005) Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J Virol 79: 2689-2699. (Pubitemid 40270547)
13. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, et al. (2005) Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci USA 102: 2992-2997. (Pubitemid 40299904)
14. Yang D, Liu N, Zuo C, Lei S, Wu X, et al. (2011) Innate host response in primary human hepatocytes with hepatitis C virus infection. PLoS One 6:e27552.
15. Blight KJ, McKeating JA, Marcotrigiano J, Rice CM (2002) High permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication. J Virol 76: 13001-13014. (Pubitemid 35386984)
16. Zhu H, Dong H, Eksioglu E, Hemming A, Cao M, et al. (2007) Hepatitis C virus triggers cell death through innate intracellular antiviral defense system. Gastroenterology 133: 1649-1659. (Pubitemid 350029762)
17. Yang D, Xue B, Wang X, Yu X, Liu N, et al. (2013) 2-Octynoic acid inhibits hepatitis C virus infection through activation of AMP-activated Protein Kinase. PLoS One 8:e64932
18. Pileri P, Uematsu Y, Campagnoli S, Galli G, Falugi F, et al. (1998) Binding of hepatitis C virus to CD81. Science 282: 938-941. (Pubitemid 28507525)
19. Yang D, Meng X, Yu Q, Xu L, Long Y, et al. (2013) Inhibition of hepatitis C virus infection by DNA aptamer against envelop protein. Antimicrob Agents and Chemother 57: 4937-4944.
20. Molina S, Castet V, Pichard-Garcia L, Wychowski C, Meurs E, et al. (2008) Serum-derived hepatitis C virus infection of primary human hepatocytes is tetraspanin CD81 dependent. J Virol 82: 569-574. (Pubitemid 350309172)
21. Zhu H, Liu C (2003) Interleukin-1 inhibit hepatitis C virus subgenomic RNA replication by activation of extracellular regulated kinase pathway. J Virol 77: 5493-5498. (Pubitemid 36460962)
22. Kato H, Takahasi K, Fujita T (2011) RIG-I-I-like receptors: cytoplasmic sensors for non-self RNA. Immunol Rev 243: 91-98.
23. Leung DW, Basler CF, Amarasinghe GK (2012) Molecular mechanisms of viral inhibitors of RIG-I-like receptors. Trends Microbiol 20: 139-146.
24. Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemc?ovic?ová I, et al. (2013) Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses. Cell Host Microbe 13: 324-335.
25. Chien H, Dix RD (2012) Evidence for multiple cell death pathways during development of experimental cytomegalovirus retinitis in mice with retrovirusinduced immunosuppression: apoptosis, necroptosis, and pyroptosis. J Virol 86: 10961-10978.
26. Rosebeck S, Leaman DW (2008) Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a. Apoptosis 13: 562-572.
27. Cho H, Proll SC, Szretter KJ, Katze MG, Gale M Jr, et al. (2013) Differential innate immune response programs in neuronal subtypes determine susceptibility to infection in the brain by positive-stranded RNA viruses. Nat Med 19: 458-464.
28. Sun Y, Leaman DW (2005) Involvement of Noxa in cellular apoptotic responses to IFN, double-stranded RNA and virus infection. J Biol Chem 280: 15561-15568. (Pubitemid 40616672)
29. Ploss A, Khetani SR, Jones CT, Syder AJ, Trehan K, et al. (2010) Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc Natl Acad Sci USA 107: 3141-3145.
30. Cheng G, Zhong J, Chisari FV (2006) Inhibition of dsRNA-induced signaling in hepatitis C virus-infected cells by NS3 protease-dependent and independent mechanisms. Proc Natl Acad Sci USA 103: 8499-8504. (Pubitemid 43838484)
31. Aly HH, Atsuzawa K, Usuda N, Takada Y, Mizokami M, et al. (2009) Straindependent viral dynamics and virus-cell interactions in a novel in vitro system supporting the life cycle of blood-borne hepatitis C virus. Hepatology 50: 689-696.
32. Horner SM, Gale M Jr (2013) Regulation of hepatic innate immunity by hepatitis C virus. Nat Med 19: 879-888.
33. Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, et al. (2006) Viral and therapeutic control of IFN-beta promoter stimulator during hepatitis C virus infection. Proc Natl Acad Sci USA 103: 6001-6006.
34. Baril M, Racine ME, Penin F, Lamarre D (2009) MAVS dimmer is a crucial signaling component of innate immunity and the target of HCV NS3/4A protease. J Virol 83: 1299-1311.
35. Horner SM, Liu H, Park HS, Briley J, Gale M Jr (2011) Mitochondrialassociated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. Proc Natl Acad Sci USA 108: 14590-14595.