Low sensitivity of the metabolic syndrome to identify adolescents with impaired glucose tolerance: An analysis of NHANES 1999-2010

Cardiovascular Diabetology

Volumn 13, Issue 1, 2014, Pages

  DeBoer, Mark D ^a   Gurka, Matthew J ^b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Adolescents; Impaired glucose tolerance; Insulin resistance; Metabolic syndrome; Type 2 diabetes

Indexed keywords

GLUCOSE;

ADOLESCENT; ADOLESCENT DISEASE; ADULT TREATMENT PANEL III CRITERION; ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE CLASSIFICATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; IMPAIRED GLUCOSE TOLERANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; METABOLIC SYNDROME Z SCORE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; RACE DIFFERENCE; RECEIVER OPERATING CHARACTERISTIC; SCREENING TEST; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; BLOOD GLUCOSE; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; GLUCOSE INTOLERANCE; HUMANS; MALE; METABOLIC SYNDROME X; NUTRITION SURVEYS; RISK FACTORS; YOUNG ADULT;

EID: 84899620427     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-13-83     Document Type: Article

References (48)

1. DeBoer MD. Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: A need for screening tools to target interventions. Nutrition 2013, 29(2):379-386. 10.1016/j.nut.2012.07.003, 3578702, 23022122.
2. Greig F, Hyman S, Wallach E, Hildebrandt T, Rapaport R. Which obese youth are at increased risk for type 2 diabetes? Latent class analysis and comparison with diabetic youth. Pediatric Diabetes 2012, 13(2):181-188. 10.1111/j.1399-5448.2011.00792.x, 22050535.
3. National Diabetes Data Group Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 1979, 28(12):1039-1057. National Diabetes Data Group.
4. Rodriguez-Moran M, Guerrero-Romero F, Aradillas-Garcia C, Violante R, Simental-Mendia LE, Monreal-Escalante E, de la Cruz ME. Obesity and family history of diabetes as risk factors of impaired fasting glucose: implications for the early detection of prediabetes. Pediatric Diabetes 2010, 11(5):331-336.
5. Weiss R, Taksali SE, Tamborlane WV, Burgert TS, Savoye M, Caprio S. Predictors of changes in glucose tolerance status in obese youth. Diabetes Care 2005, 28(4):902-909. 10.2337/diacare.28.4.902, 15793193.
6. Weiss R. Impaired glucose tolerance and risk factors for progression to type 2 diabetes in youth. Pediatric Diabetes 2007, 8:70-75. 10.1111/j.1399-5448.2007.00336.x, 17991135.
7. Kleber M, Lass N, Papcke S, Wabitsch M, Reinehr T. One-year follow-up of untreated obese white children and adolescents with impaired glucose tolerance: high conversion rate to normal glucose tolerance. Diabetic Medicine 2010, 27(5):516-521. 10.1111/j.1464-5491.2010.02991.x, 20536946.
8. Grandone A, Amato A, Luongo C, Santoro N, Perrone L, del Giudice EM. High-normal fasting glucose levels are associated with increased prevalence of impaired glucose tolerance in obese children. J Endocrinol Investig 2008, 31(12):1098-1102.
9. Amer Diabet A. Standards of Medical Care in Diabetes-2013. Diabetes Care 2013, 36:S11-S66. 3537269, 23264422.
10. Sosenko JM, Palmer JP, Rafkin-Mervis L, Krischer JP, Cuthbertson D, Matheson D, Skyler JS. Glucose and C-Peptide Changes in the Perionset Period of Type 1 Diabetes in the Diabetes Prevention Trial-Type 1. Diabetes Care 2008, 31(11):2188-2192. 10.2337/dc08-0935, 2571043, 18650369.
11. Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, McCrindle B, Mietus-Snyder ML. Progress and Challenges in Metabolic Syndrome in Children and Adolescents A Scientific Statement From the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2009, 119(4):628-647. 10.1161/CIRCULATIONAHA.108.191394, 19139390.
12. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Spertus JS, Costa F,. American Heart Association; National Heart, Lung, and Blood Institute Diagnosis and management of the metabolic syndrome - An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005, 112(17):2735-2752. 10.1161/CIRCULATIONAHA.105.169404, 16157765, American Heart Association; National Heart, Lung, and Blood Institute.
13. Sumner AD, Sardi GL, Reed JF. Components of the Metabolic Syndrome Differ Between Young and Old Adults in the US Population. J Clin Hypertens 2012, 14(8):502-506.
14. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, Allen K, Lopes M, Savoye M, Morrison J, Sherwin RS, Caprio S. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004, 350(23):2362-2374. 10.1056/NEJMoa031049, 15175438.
15. Lee S, Bacha F, Gungor N, Arslanian S. Comparison of different definitions of pediatric metabolic syndrome: Relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. J Pediatr 2008, 152(2):177-184. 10.1016/j.jpeds.2007.07.053, 18206686.
16. Lee S, Gungor N, Bacha F, Arslanian S. Insulin resistance: link to the components of the metabolic syndrome and biomarkers of endothelial dysfunction in youth (Vol 30, Pg 2091, 2007). Diabetes Care 2007, 30(10):2763-2763.
17. Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus. Diabetes 2009, 58(4):773-795. 10.2337/db09-9028, 2661582, 19336687.
18. Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS?. Year Diabetes and Obes 2010, 1212:59-77.
19. Morrison JA, Friedman LA, Wang P, Glueck CJ. Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later. J Pediatr 2008, 152(2):201-206. 10.1016/j.jpeds.2007.09.010, 18206689.
20. Johnson WD, Kroon JJ, Greenway FL, Bouchard C, Ryan D, Katzmarzyk PT. Prevalence of risk factors for metabolic syndrome in adolescents: National Health and Nutrition Examination Survey (NHANES), 2001-2006. Arch Pediatr Adolesc Med 2009, 163(4):371-377. 10.1001/archpediatrics.2009.3, 19349567.
21. Liese AD, D'Agostino RB, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, Loots B, Linder B, Marcovina S, Rodriguez B, Standiford D, Williams DE. The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 2006, 118(4):1510-1518.
22. Sumner AE. Ethnic Differences in Triglyceride Levels and High-Density Lipoprotein Lead to Underdiagnosis of the Metabolic Syndrome in Black Children and Adults. Journal of Pediatrics 2009, 155(S7):e7-e11. 3275909, 19732569.
23. DeBoer MD. Ethnicity, obesity and the metabolic syndrome: implications on assessing risk and targeting intervention. Expert Rev Endocrinol Metab 2011, 6(2):279-289. 10.1586/eem.11.17, 3105461, 21643518.
24. DeBoer MD, Gurka MJ, Sumner AE. Diagnosis of the Metabolic Syndrome Is Associated With Disproportionately High Levels of High-Sensitivity C-Reactive Protein in Non-Hispanic Black Adolescents: An analysis of NHANES 1999-2008. Diabetes Care 2011, 34(3):734-740. 10.2337/dc10-1877, 3041218, 21285387.
25. DeBoer MD, Dong L, Gurka MJ. Racial/Ethnic and Sex Differences in the Ability of Metabolic Syndrome Criteria to Predict Elevations in Fasting Insulin Levels in Adolescents. J Pediatr 2011, 159(6):975-U141. 10.1016/j.jpeds.2011.05.023, 3202665, 21784441.
26. DeBoer MD, Gurka MJ. Low sensitivity for the metabolic syndrome to detect uric acid elevations in females and non-Hispanic-black male adolescents: An analysis of NHANES 1999-2006. Atherosclerosis 2012, 220(2):575-580. 10.1016/j.atherosclerosis.2011.11.033, 3321243, 22178428.
27. Gurka MJ, Ice CL, Sun SS, DeBoer MD. A confirmatory factor analysis of the metabolic syndrome in adolescents: an examination of sex and racial/ethnic differences. Cardiovasc Diabetol 2012, 11:128. 10.1186/1475-2840-11-128, 3489601, 23062212.
28. Gurka MJ, Lilly CL, Norman OM, DeBoer MD. An Examination of Sex and Racial/Ethnic Differences in the Metabolic Syndrome among Adults: A Confirmatory Factor Analysis and a Resulting Continuous Severity Score. Metabolism 2014, 63(2):218-225. 10.1016/j.metabol.2013.10.006, 24290837.
29. Ford ES, Li C, Cook S, Choi HK. Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation 2007, 115(19):2526-2532. 10.1161/CIRCULATIONAHA.106.657627, 17470699.
30. Fernandez JR, Redden DT, Pietrobelli A, Allison DB. Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents. J Pediatr 2004, 145(4):439-444. 10.1016/j.jpeds.2004.06.044, 15480363.
31. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004, 114(2):555-576. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents.
32. Rhodes ET, Goran MI, Lieu TA, Lustig RH, Prosser LA, Songer TJ, Weigensberg MJ, Weinstock RS, Gonzalez T, Rawluk K, Zoqhbi RM, Ludwig DS, Laffel LM. Health-Related Quality of Life in Adolescents with or at Risk for Type 2 Diabetes Mellitus. J Pediatr 2012, 160(6):911-917. 10.1016/j.jpeds.2011.11.026, 22217471.
33. Ascaso JF, Romero P, Real JT, Lorente RI, Martinez-Valls J, Carmena R. Abdominal obesity, insulin resistance, and metabolic syndrome in a southern European population. Eur J Intern Med 2003, 14(2):101-106. 10.1016/S0953-6205(03)00022-0, 12719027.
34. Ramachandran A, Satyavani K, Snehalatha C, Vijay V, Latha E. Clustering of cardiovascular risk factors in urban Asian Indians. Diabetes Care 1998, 21(6):967-971. 10.2337/diacare.21.6.967, 9614615.
35. Del Prato S, Tiengo A. The importance of first-phase insulin secretion: implications for the therapy of type 2 diabetes mellitus. Diabetes Metabol Res Rev 2001, 17(3):164-174.
36. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Investig 2006, 116(7):1802-1812. 10.1172/JCI29103, 1483155, 16823478.
37. Kashyap S, Belfort R, Gastaldelli A, Pratipanawatr T, Berria R, Pratipanawatr W, Bajaj M, Mandarino L, DeFronzo R, Cusi K. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 2003, 52(10):2461-2474. 10.2337/diabetes.52.10.2461, 14514628.
38. Rossetti L, Giaccari A, Defronzo RA. Glucose toxicity. Diabetes Care 1990, 13(6):610-630. 10.2337/diacare.13.6.610, 2192847.
39. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, 346(6):393-403. 1370926, 11832527.
40. Stern MP, Williams K, Haffner SA. Identification of persons at high risk for type 2 diabetes mellitus: Do we need the oral glucose tolerance test?. Ann Intern Med 2002, 136(8):575-581. 10.7326/0003-4819-136-8-200204160-00006, 11955025.
41. Jallut D, Golay A, Munger R, Frascarolo P, Schutz Y, Jequier E, Felber JP. Impaired Glucose-Tolerance and Diabetes in Obesity - A 6-year follow-up-study of Glucose-Metabolism. Metabol Clin Exp 1990, 39(10):1068-1075.
42. Pihoker C, Gilliam LK, Ellard S, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, Hattersley AT,. SEARCH for Diabetes in Youth Study Group Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results From the SEARCH for Diabetes in Youth. J Clin Endocrinol Metabol 2013, 98(10):4055-4062. SEARCH for Diabetes in Youth Study Group.
43. Steck AK, Winter WE. Review on monogenic diabetes. Curr Opin Endocrinol Diabetes Obes 2011, 18(4):252-258. 10.1097/MED.0b013e3283488275, 21844708.
44. Bennett B, Larson-Meyer DE, Ravussin E, Volaufova J, Soros A, Cefalu WT, Chalew S, Gordon S, Smith SR, Newcomer BR, Goran M, Sothern M. Impaired Insulin Sensitivity and Elevated Ectopic Fat in Healthy Obese vs. Nonobese Prepubertal Children. Obesity 2012, 20(2):371-375. 10.1038/oby.2011.264, 21869763.
45. Giuffrida FMA, Guedes AD, Rocco ER, Mory DB, Dualib P, Matos OS, Chaves-Fonseca RM, Cobas RA, Negrato CA, Gomes MB, dib SA,. Brazilian Type 1 Diabetes Study Group Heterogeneous behavior of lipids according to HbA1(c) levels undermines the plausibility of metabolic syndrome in type 1 diabetes: data from a nationwide multicenter survey. Cardiovascular Diabetology 2012, 11:156. 10.1186/1475-2840-11-156, 3547761, 23270560, Brazilian Type 1 Diabetes Study Group.
46. Mayer-Davis EJ, Bell RA, Dabelea D, D'Agostino R, Imperatore G, Lawrence JM, Liu L, Marcovina S, Grp SDYS. The Many Faces of Diabetes in American Youth: Type 1 and Type 2 Diabetes in Five Race and Ethnic Populations: The Search for Diabetes in Youth Study Introduction. Diabetes Care 2009, 32:S99-S101. 10.2337/dc09-S201, 2647691, 19246580.
47. Torres JM, Cox NJ, Philipson LH. Genome wide association studies for diabetes: perspective on results and challenges. Pediatr Diabetes 2013, 14(2):90-96. 10.1111/pedi.12015, 23350725.
48. Schwartz B, Jacobs DR, Moran A, Steinberger J, Hong CP, Sinaiko AR. Measurement of insulin sensitivity in children: comparison between the euglycemic-hyperinsulinemic clamp and surrogate measures. Diabetes Care 2008, 31(4):783-788. 10.2337/dc07-1376, 18174496.