Discovery of novel diarylpyrimidines as potent HIV NNRTIs via a structure-guided core-refining approach

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 112-121

  Li, Xiao ^a   Chen, Wenmin ^a   Tian, Ye ^a   Liu, Huiqing ^a   Zhan, Peng ^a   De Clercq, Erik ^b   Pannecouque, Christophe ^b   Jan, Balzarini ^b   Liu, Xinyong ^a  

^a SHANDONG UNIVERSITY   (China)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti HIV activities; DAPY; HIV 1; HIV 2; Keywords; Molecular modeling; Structure activity relationships

Indexed keywords

ETRAVIRINE; NEVIRAPINE; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RILPIVIRINE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MOLECULAR MODEL; MUTANT; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION; WILD TYPE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MOLECULAR DOCKING; PHYSIOLOGY; PROTEIN CONFORMATION;

DRUG DESIGN; HIV REVERSE TRANSCRIPTASE; HIV-1; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 84899576876     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.036     Document Type: Article

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