Synthesis and SAR studies of trisubstituted purinones as potent and selective adenosine A2A receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 5, 2009, Pages 1399-1402

  Shao, Yuefei ^a   Cole, Andrew G ^a   Brescia, Marc Raleigh ^a   Qin, Lan Ying ^a   Duo, Jingqi ^a   Stauffer, Tara M ^a   Rokosz, Laura L ^a   McGuinness, Brian F ^a   Henderson, Ian ^a  

^a PHARMACOPEIA INC   (United States)

Author keywords

Adenosine; GPCR; Parkinson's disease; Purinone; SAR

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; CYCLIC AMP; PURINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CHEMICAL STRUCTURE; PARKINSON DISEASE; PROTEIN BINDING; PROTEIN STRUCTURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; SYNTHESIS;

ANIMALS; HUMANS; PROTEIN BINDING; PURINONES; RATS; RECEPTOR, ADENOSINE A2A; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 60449114782     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.01.042     Document Type: Article

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