-
1
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
I. Kola, and J. Landis Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3 2004 711 716
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 711-716
-
-
Kola, I.1
Landis, J.2
-
2
-
-
79959913133
-
Protein microarrays: Novel developments and applications
-
L. Berrade et al. Protein microarrays: novel developments and applications Pharm. Res. 28 2011 1480 1499
-
(2011)
Pharm. Res.
, vol.28
, pp. 1480-1499
-
-
Berrade, L.1
-
3
-
-
77149157477
-
Label-free detection techniques for protein microarrays: Prospects, merits and challenges
-
S. Ray et al. Label-free detection techniques for protein microarrays: prospects, merits and challenges Proteomics 10 2010 731 748
-
(2010)
Proteomics
, vol.10
, pp. 731-748
-
-
Ray, S.1
-
4
-
-
33846051527
-
Protein microarray technology
-
D.A. Hall et al. Protein microarray technology Mech. Ageing Dev. 128 2007 161 167
-
(2007)
Mech. Ageing Dev.
, vol.128
, pp. 161-167
-
-
Hall, D.A.1
-
5
-
-
70349156763
-
Dissecting protein function and signaling using protein microarrays
-
A. Wolf-Yadlin et al. Dissecting protein function and signaling using protein microarrays Curr. Opin. Chem. Biol. 13 2009 398 405
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, pp. 398-405
-
-
Wolf-Yadlin, A.1
-
6
-
-
78149301758
-
Sequential multiplex analyte capturing for phosphoprotein profiling
-
O. Poetz et al. Sequential multiplex analyte capturing for phosphoprotein profiling Mol. Cell. Proteomics 9 2010 2474 2481
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 2474-2481
-
-
Poetz, O.1
-
7
-
-
74549168922
-
Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data
-
A. Mitsos et al. Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data PLoS Comput. Biol. 5 2009 e1000591
-
(2009)
PLoS Comput. Biol.
, vol.5
, pp. 1000591
-
-
Mitsos, A.1
-
8
-
-
77956554551
-
Networks inferred from biochemical data reveal profound differences in Toll-like receptor and inflammatory signaling between normal and transformed hepatocytes
-
L.G. Alexopoulos et al. Networks inferred from biochemical data reveal profound differences in Toll-like receptor and inflammatory signaling between normal and transformed hepatocytes Mol. Cell. Proteomics 9 2010 1849 1865
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1849-1865
-
-
Alexopoulos, L.G.1
-
9
-
-
77952956167
-
Decoding signalling networks by mass spectrometry-based proteomics
-
C. Choudhary, and M. Mann Decoding signalling networks by mass spectrometry-based proteomics Nat. Rev. Mol. Cell Biol. 11 2010 427 439
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 427-439
-
-
Choudhary, C.1
Mann, M.2
-
10
-
-
68949206409
-
Applying mass spectrometry-based proteomics to genetics, genomics and network biology
-
M. Gstaiger, and R. Aebersold Applying mass spectrometry-based proteomics to genetics, genomics and network biology Nat. Rev. Genet. 10 2009 617 627
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 617-627
-
-
Gstaiger, M.1
Aebersold, R.2
-
11
-
-
77955345941
-
Profiling of protein interaction networks of protein complexes using affinity purification and quantitative mass spectrometry
-
R.M. Kaake et al. Profiling of protein interaction networks of protein complexes using affinity purification and quantitative mass spectrometry Mol. Cell. Proteomics 9 2010 1650 1665
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1650-1665
-
-
Kaake, R.M.1
-
12
-
-
72449196261
-
Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics
-
C. Pan et al. Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics Mol. Cell. Proteomics 8 2009 2796 2808
-
(2009)
Mol. Cell. Proteomics
, vol.8
, pp. 2796-2808
-
-
Pan, C.1
-
13
-
-
33845329203
-
Functional and quantitative proteomics using SILAC
-
M. Mann Functional and quantitative proteomics using SILAC Nat. Rev. Mol. Cell Biol. 7 2006 952 958
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 952-958
-
-
Mann, M.1
-
14
-
-
77951644400
-
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
-
J.V. Olsen et al. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis Sci. Signal. 3 2010 ra3
-
(2010)
Sci. Signal.
, vol.3
, pp. 3
-
-
Olsen, J.V.1
-
15
-
-
40649095957
-
Quantitative proteomics using stable isotope labeling with amino acids in cell culture
-
H.C. Harsha et al. Quantitative proteomics using stable isotope labeling with amino acids in cell culture Nat. Protocols 3 2008 505 516
-
(2008)
Nat. Protocols
, vol.3
, pp. 505-516
-
-
Harsha, H.C.1
-
16
-
-
0142244231
-
Phosphorylation state-specific antibodies: Applications in investigative and diagnostic pathology
-
J.W. Mandell Phosphorylation state-specific antibodies: applications in investigative and diagnostic pathology Am. J. Pathol. 163 2003 1687 1698
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 1687-1698
-
-
Mandell, J.W.1
-
17
-
-
0036510366
-
Negative regulation of Toll-like receptor-mediated signaling by tollip
-
G. Zhang, and S. Ghosh Negative regulation of Toll-like receptor-mediated signaling by tollip J. Biol. Chem. 277 2002 7059 7065
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7059-7065
-
-
Zhang, G.1
Ghosh, S.2
-
18
-
-
0019790941
-
Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten
-
A.H. Ross et al. Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten Nature 294 1981 654 656
-
(1981)
Nature
, vol.294
, pp. 654-656
-
-
Ross, A.H.1
-
19
-
-
0024804924
-
Antibodies and radioimmunoassays for phosphoserine, phosphothreonine and phosphotyrosine. Serologic specificities and levels of the phosphoamino acids in cytoplasmic fractions of rat tissues
-
L. Levine et al. Antibodies and radioimmunoassays for phosphoserine, phosphothreonine and phosphotyrosine. Serologic specivicities and levels of the phospxoamino acids in cytoplasmic fractions of rat tissues J. Immunol. Methods 124 1989 239 249
-
(1989)
J. Immunol. Methods
, vol.124
, pp. 239-249
-
-
Levine, L.1
-
20
-
-
21144458164
-
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
-
J. Rush et al. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells Nat. Biotechnol. 23 2005 94 101
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 94-101
-
-
Rush, J.1
-
21
-
-
84857647499
-
Standardizing immunophenotyping for the Human Immunology Project
-
H.T. Maecker et al. Standardizing immunophenotyping for the Human Immunology Project Nat. Rev. Immunol. 12 2012 191 200
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 191-200
-
-
Maecker, H.T.1
-
22
-
-
84877839658
-
An introduction to mass cytometry: Fundamentals and applications
-
S.D. Tanner et al. An introduction to mass cytometry: fundamentals and applications Cancer Immunol. Immunother. 62 2013 955 965
-
(2013)
Cancer Immunol. Immunother.
, vol.62
, pp. 955-965
-
-
Tanner, S.D.1
-
23
-
-
68849103521
-
Mass cytometry: Technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry
-
D.R. Bandura et al. Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry Anal. Chem. 81 2009 6813 6822
-
(2009)
Anal. Chem.
, vol.81
, pp. 6813-6822
-
-
Bandura, D.R.1
-
24
-
-
34547881522
-
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
-
P.H. Huang et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma Proc. Natl. Acad. Sci. U. S. A. 104 2007 12867 12872
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 12867-12872
-
-
Huang, P.H.1
-
25
-
-
79952386422
-
Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of (EGFR
-
V. Chumbalkar et al. Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of (EGFR J. Proteome Res. 10 2011 1343 1352
-
(2011)
J. Proteome Res.
, vol.10
, pp. 1343-1352
-
-
Chumbalkar, V.1
-
26
-
-
60149089005
-
Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy
-
J. Du et al. Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy Nat. Biotechnol. 27 2009 77 83
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 77-83
-
-
Du, J.1
-
27
-
-
79959223703
-
Phosphoproteomic screen identifies potential therapeutic targets in melanoma
-
K. Tworkoski et al. Phosphoproteomic screen identifies potential therapeutic targets in melanoma Mol. Cancer Res. 9 2011 801 812
-
(2011)
Mol. Cancer Res.
, vol.9
, pp. 801-812
-
-
Tworkoski, K.1
-
28
-
-
78149427796
-
Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL
-
B. Accordi et al. Functional protein network activation mapping reveals new potential molecular drug targets for poor prognosis pediatric BCP-ALL PLoS ONE 5 2010 e13552
-
(2010)
PLoS ONE
, vol.5
, pp. 13552
-
-
Accordi, B.1
-
29
-
-
77949848665
-
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer
-
J. Li et al. A chemical and phosphoproteomic characterization of dasatinib action in lung cancer Nat. Chem. Biol. 6 2010 291 299
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 291-299
-
-
Li, J.1
-
30
-
-
34948875686
-
Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors
-
M. Bantscheff et al. Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors Nat. Biotechnol. 25 2007 1035 1044
-
(2007)
Nat. Biotechnol.
, vol.25
, pp. 1035-1044
-
-
Bantscheff, M.1
-
31
-
-
78149405523
-
Proteomics analysis of cellular imatinib targets and their candidate downstream effectors
-
S.B. Breitkopf et al. Proteomics analysis of cellular imatinib targets and their candidate downstream effectors J. Proteome Res. 9 2010 6033 6043
-
(2010)
J. Proteome Res.
, vol.9
, pp. 6033-6043
-
-
Breitkopf, S.B.1
-
32
-
-
84857943078
-
Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response
-
M111.014654
-
K. Sharma et al. Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response Mol. Cell. Proteomics 11 2012 M111.014654
-
(2012)
Mol. Cell. Proteomics
, vol.11
-
-
Sharma, K.1
-
33
-
-
69249240179
-
Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis
-
A. Huber et al. Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis Genes Dev. 23 2009 1929 1943
-
(2009)
Genes Dev.
, vol.23
, pp. 1929-1943
-
-
Huber, A.1
-
34
-
-
80051692878
-
Comparing signaling networks between normal and transformed hepatocytes using discrete logical models
-
J. Saez-Rodriguez et al. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models Cancer Res. 71 2011 5400 5411
-
(2011)
Cancer Res.
, vol.71
, pp. 5400-5411
-
-
Saez-Rodriguez, J.1
-
35
-
-
84859880192
-
Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data
-
I.N. Melas et al. Construction of large signaling pathways using an adaptive perturbation approach with phosphoproteomic data Mol. Biosyst. 8 2012 1571 1584
-
(2012)
Mol. Biosyst.
, vol.8
, pp. 1571-1584
-
-
Melas, I.N.1
-
36
-
-
71449120701
-
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction
-
J. Saez-Rodriguez et al. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction Mol. Syst. Biol. 5 2009 331
-
(2009)
Mol. Syst. Biol.
, vol.5
, pp. 331
-
-
Saez-Rodriguez, J.1
-
37
-
-
34447551397
-
Structural and functional analysis of cellular networks with CellNetAnalyzer
-
S. Klamt et al. Structural and functional analysis of cellular networks with CellNetAnalyzer BMC Syst. Biol. 1 2007 2
-
(2007)
BMC Syst. Biol.
, vol.1
, pp. 2
-
-
Klamt, S.1
-
38
-
-
79953668247
-
Training signaling pathway maps to biochemical data with constrained fuzzy logic: Quantitative analysis of liver cell responses to inflammatory stimuli
-
M.K. Morris et al. Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli PLoS Comput. Biol. 7 2011 e1001099
-
(2011)
PLoS Comput. Biol.
, vol.7
, pp. 1001099
-
-
Morris, M.K.1
-
39
-
-
84870577280
-
Non linear programming (NLP) formulation for quantitative modeling of protein signal transduction pathways
-
A. Mitsos et al. Non linear programming (NLP) formulation for quantitative modeling of protein signal transduction pathways PLoS ONE 7 2012 e50085
-
(2012)
PLoS ONE
, vol.7
, pp. 50085
-
-
Mitsos, A.1
-
40
-
-
17644427718
-
Causal protein-signaling networks derived from multiparameter single-cell data
-
K. Sachs et al. Causal protein-signaling networks derived from multiparameter single-cell data Science 308 2005 523 529
-
(2005)
Science
, vol.308
, pp. 523-529
-
-
Sachs, K.1
-
41
-
-
84859994220
-
Computational approaches for analyzing information flow in biological networks
-
B. Kholodenko et al. Computational approaches for analyzing information flow in biological networks Sci. Signal. 5 2012 1
-
(2012)
Sci. Signal.
, vol.5
, pp. 1
-
-
Kholodenko, B.1
-
42
-
-
33847055114
-
How to infer gene networks from expression profiles
-
M. Bansal et al. How to infer gene networks from expression profiles Mol. Syst. Biol. 3 2007 78
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 78
-
-
Bansal, M.1
-
43
-
-
79959816776
-
Combined logical and data-driven models for linking signalling pathways to cellular response
-
I. Melas et al. Combined logical and data-driven models for linking signalling pathways to cellular response BMC Syst. Biol. 5 2011 107
-
(2011)
BMC Syst. Biol.
, vol.5
, pp. 107
-
-
Melas, I.1
-
44
-
-
84855874661
-
Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells
-
C. Weber et al. Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells J. Proteomics 75 2012 1343 1356
-
(2012)
J. Proteomics
, vol.75
, pp. 1343-1356
-
-
Weber, C.1
-
45
-
-
77954693401
-
Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists
-
G.L. Christensen et al. Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists Mol. Cell. Proteomics 9 2010 1540 1553
-
(2010)
Mol. Cell. Proteomics
, vol.9
, pp. 1540-1553
-
-
Christensen, G.L.1
-
46
-
-
84866096861
-
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators
-
B. Bodenmiller et al. Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators Nat. Biotechnol. 30 2012 858 867
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 858-867
-
-
Bodenmiller, B.1
-
47
-
-
77953593640
-
Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation
-
B.D. Cosgrove et al. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation Mol. Biosyst. 6 2010 1195 1206
-
(2010)
Mol. Biosyst.
, vol.6
, pp. 1195-1206
-
-
Cosgrove, B.D.1
-
48
-
-
77952552373
-
The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity
-
D.E. Amacher The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity Toxicol. Appl. Pharmacol. 245 2010 134 142
-
(2010)
Toxicol. Appl. Pharmacol.
, vol.245
, pp. 134-142
-
-
Amacher, D.E.1
-
49
-
-
84857684723
-
Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity
-
A. Van Summeren et al. Proteomics in the search for mechanisms and biomarkers of drug-induced hepatotoxicity Toxicol. In Vitro 26 2012 373 385
-
(2012)
Toxicol. in Vitro
, vol.26
, pp. 373-385
-
-
Van Summeren, A.1
-
50
-
-
41149108215
-
Strategic approach to fit-for-purpose biomarkers in drug development
-
J.A. Wagner Strategic approach to fit-for-purpose biomarkers in drug development Annu. Rev. Pharmacol. Toxicol. 48 2008 631 651
-
(2008)
Annu. Rev. Pharmacol. Toxicol.
, vol.48
, pp. 631-651
-
-
Wagner, J.A.1
-
51
-
-
80055025828
-
Identification of direct target engagement biomarkers for kinase-targeted therapeutics
-
C.P. Paweletz et al. Identification of direct target engagement biomarkers for kinase-targeted therapeutics PLoS ONE 6 2011 e26459
-
(2011)
PLoS ONE
, vol.6
, pp. 26459
-
-
Paweletz, C.P.1
-
52
-
-
78149473552
-
Proteomic and transcriptomic profiling reveals a link between the PI3 K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer
-
C. Creighton et al. Proteomic and transcriptomic profiling reveals a link between the PI3 K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer Breast Cancer Res. 12 2010 R40
-
(2010)
Breast Cancer Res.
, vol.12
, pp. 40
-
-
Creighton, C.1
-
53
-
-
77955648969
-
Pathway-based identification of biomarkers for targeted therapeutics: Personalized oncology with PI3K pathway inhibitors
-
J.N. Andersen et al. Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors Sci. Transl. Med. 2 2010 43ra55
-
(2010)
Sci. Transl. Med.
, vol.2
-
-
Andersen, J.N.1
-
54
-
-
79951871564
-
Setting the standards for signal transduction research
-
J. Saez-Rodriguez et al. Setting the standards for signal transduction research Sci. Signal. 4 2011 pe10
-
(2011)
Sci. Signal.
, vol.4
, pp. 10
-
-
Saez-Rodriguez, J.1
-
55
-
-
33750351769
-
Data-driven modelling of signal-transduction networks
-
K.A. Janes, and M.B. Yaffe Data-driven modelling of signal-transduction networks Nat. Rev. Mol. Cell Biol. 7 2006 820 828
-
(2006)
Nat. Rev. Mol. Cell Biol.
, vol.7
, pp. 820-828
-
-
Janes, K.A.1
Yaffe, M.B.2
|