Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

Journal of Lipid Research

Volumn 55, Issue 5, 2014, Pages 929-938

  Fügi, Matthias A ^a,b   Gunasekera, Kapila ^c   Ochsenreiter, Torsten ^c   Guan, Xueli ^a,b   Wenk, Markus R ^a,b,d,e   Mäser, Pascal ^a,b  

^a SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Comparative genomics; Giardia; Hidden Markov model; Hierarchical clustering; Sterol biosynthesis inhibitor; Sterol metabolism; Trypanosoma

Indexed keywords

FENPROPIMORPH; KETOCONAZOLE; SIMVASTATIN; TERBINAFINE; TILUDRONIC ACID; ANTIPARASITIC AGENT; ERGOSTEROL; STEROL;

ANIMAL CELL; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; CONVERGENT EVOLUTION; DRUG SENSITIVITY; ENDOPARASITE; GENE EXPRESSION; GENOMICS; GIARDIA LAMBLIA; HIDDEN MARKOV MODEL; LEISHMANIA DONOVANI; MAMMAL CELL; MYOBLAST; NONHUMAN; PARASITE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RAT; STEROL METABOLISM; STEROL SYNTHESIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; ANIMAL; BIOSYNTHESIS; CELL LINE; COMPUTER SIMULATION; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR EVOLUTION; PROBABILITY;

ANIMALS; ANTIPARASITIC AGENTS; CELL LINE; CLUSTER ANALYSIS; COMPUTER SIMULATION; ERGOSTEROL; EVOLUTION, MOLECULAR; GENOMICS; MARKOV CHAINS; PARASITES; STEROLS;

EID: 84899552981     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M048017     Document Type: Article

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