An aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress the Th17 response in allergic rhinitis patients

Laboratory Investigation

Volumn 94, Issue 5, 2014, Pages 528-535

  Wei, Ping ^a   Hu, Guo Hua ^a   Kang, Hou Yong ^a   Yao, Hong Bing ^a   Kou, Wei ^a   Liu, Hong ^a   Zhang, Cheng ^a   Hong, Su Ling ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

2 (10H indole 30 carbonyl) thiazole 4 carboxylic acid methyl ester (ITE); allergic rhinitis; aryl hydrocarbon receptor; dendritic cells; Th17

Indexed keywords

2 (1' H INDOLE 3' CARBONYL)THIAZOLE 4 CARBOXYLIC ACID METHYL ESTER; AROMATIC HYDROCARBON RECEPTOR; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 6; UNCLASSIFIED DRUG;

ALLERGIC RHINITIS; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL CULTURE; CELL ISOLATION; CELLULAR IMMUNITY; CELLULAR SECRETION; CLINICAL ARTICLE; COCULTURE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; TH17 CELL;

CASE-CONTROL STUDIES; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; DENDRITIC CELLS; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; INDOLES; INTERLEUKINS; MALE; RECEPTORS, ARYL HYDROCARBON; RHINITIS, ALLERGIC, PERENNIAL; TH17 CELLS; THIAZOLES;

EID: 84899548112     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.8     Document Type: Article

References (27)

1. Dykewicz MS, Hamilos DL. Rhinitis and sinusitis. J Allergy Clin Immunol 2010;125:S103-S115.
2. Katelaris CH, Lee BW, Potter PC, et al. Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. Clin Exp Allergy 2012;42:186-207.
3. Bauchau V, Durham SR. Epidemiological characterization of the intermittent and persistent types of allergic rhinitis. Allergy 2005;60: 350-353.
4. Bajoriuniene I, Malakauskas K, Lavinskiene S, et al. Response of peripheral blood Th17 cells to inhaled dermatophagoides pteronyssinus in patients with allergic rhinitis and asthma. Lung 2012;190: 487-495.
5. Ciprandi G, De Amici M, Murdaca G, et al. Serum interleukin-17 levels are related to clinical severity in allergic Rhinitis. Allergy 2009;64: 1375-1378.
6. Murdaca G, Colombo BM, Puppo F. The role of Th17 lymphocytes in the autoimmune and chronic inflammatory diseases. Intern Emerg Med 2011;6:487-495.
7. Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 2003;43:309-334.
8. Quintana FJ, Basso AS, Iglesias AH, et al. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008; 453:65-71.
9. Esser C, Rannug A, Stockinger B. The aryl hydrocarbon receptor in immunity. Trends Immunol 2009;30:447-454.
10. Nguyen Nam Trung, Hanieh Hamza, Nakahama Taisuke, et al. The roles of aryl hydrocarbon receptor in immune Responses. Int Immunol 2013;25:335-343.
11. Platzer B, Richter S, Kneidinger D, et al. Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells. J Immunol 2009;183:66-74.
12. Quintana FJ, Murugaiyan G, Farez MF, et al. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2010;107:20768-20773.
13. Wei P, Hu GH, Kang HY, et al. Increased aryl hydrocarbon receptor expression in patients with allergic rhinitis. QJM 2013. doi:10.1093/qjmed/ hct188.
14. Pawankar R, Bunnag C, Khaltaev N, et al. Allergic rhinitis and its impact on asthma in Asia Pacific and the ARIA update 2008. World Allergy Organ J 2012;5:S212-S217.
15. Dreborg S, Backman A, Basomba A. Skin tests used in type I allergy testing. Position paper. Allergy 1989;44:1-59.
16. Kimura A, Naka T, Nohara K, et al. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci USA 2008;105:9721-9726.
17. Zhou Q, Xiao X, Wang C, et al. Decreased microRNA-155 expression in ocular Behcet's disease but not in Vogt Koyanagi Harada syndrome. Invest Ophthalmol Vis Sci 2012;53:5665-5674.
18. Shen Y, Hu GH, Yang YC, et al. Allergen induced Th17 response in the peripheral blood mononuclear cells (PBMCs) of patients with nasal polyposis. Int Immunopharmacol 2011;12:235-240.
19. Maggi. E. T cell responses induced by allergen-specific immunotherapy. Clin Exp Immunol 2010;161:10-18.
20. Nguyen LP, Bradfield CA. The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol 2008;21: 102-116.
21. McLellan AD, Brocker EB, Kampgen E. Dendritic cell activation by danger and antigen-specific T-cell signalling. Exp Dermatol 2000;9: 313-322.
22. Hauben E, Greqori S, Draghici E, et al. Activation of the aryl hydrocarbon receptor promotes allograft-specific tolerance through direct and dendritic cell-mediated effects on regulatory T cells. Blood 2008; 112:1214-1222.
23. Machado FS, Johndrow JE, Esper L, et al. Anti-inflammatory actions of lipoxin A4 and aspirin triggered lipoxin are SOCS-2 dependent. Nat Med 2006;12:330-334.
24. Platzer B, Richter S, Kneidinger D, et al. Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells. J Immunol 2009;183: 66-74.
25. Simones T, Shepherd DM. Consequences of AhR activation in steadystate dendritic cells. Transfus Sci 2011;119:293-307.
26. Gandhi R, Kumar D, Burns EJ, et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(\+) regulatory T cells. Nat Immunol 2010;11:846-853.
27. Ling EM, Smith T, Nguyen XD, et al. Relation of CD4\+CD25\+ regulatory T-cell suppression of allergen driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004;363:608-615.