Oversulfated chondroitin sulfate binds to chemokines and inhibits stromal cell-derived factor-1 mediated signaling in activated T cells

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Zhou, Zhao Hua ^a   Karnaukhova, Elena ^b   Rajabi, Mohsen ^a   Reeder, Kelly ^a   Chen, Trina ^a   Dhawan, Subhash ^b   Kozlowski, Steven ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CCL1 CHEMOKINE; CHEMOKINE; CHONDROITIN SULFATE; CXCL11 CHEMOKINE; CXCL13 CHEMOKINE; CXCL16 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; OVERSULFATED CHONDROITIN SULFATE; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1ALPHA; STROMAL CELL DERIVED FACTOR 1BETA; UNCLASSIFIED DRUG; GLYCOSAMINOGLYCAN; STROMAL CELL DERIVED FACTOR 1;

ADAPTIVE IMMUNITY; ARTICLE; CALCIUM MOBILIZATION; CELL STRUCTURE; CHEMOTAXIS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; T LYMPHOCYTE; CALCIUM SIGNALING; CELL SHAPE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM;

CALCIUM SIGNALING; CELL SHAPE; CHEMOKINE CXCL12; CHEMOTAXIS; CHONDROITIN SULFATES; GLYCOSAMINOGLYCANS; HUMANS; LYMPHOCYTE ACTIVATION; PROTEIN STRUCTURE, SECONDARY; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84899532757     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0094402     Document Type: Article

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