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Volumn 45, Issue 3, 2014, Pages 229-236

Expression of Epstein-Barr Virus-encoded Latent Membrane Protein (LMP-1), p16 and p53 Proteins in Nonendemic Nasopharyngeal Carcinoma (NPC): AClinicopathological Study

Author keywords

EBV LMP1; Immunohistochemistry; Nasopharyngeal carcinoma; P16; P53

Indexed keywords

CISPLATIN; FLUOROURACIL; GEMCITABINE; LATENT MEMBRANE PROTEIN 1; PROTEIN P16; PROTEIN P53;

EID: 84899520166     PISSN: 01884409     EISSN: 18735487     Source Type: Journal    
DOI: 10.1016/j.arcmed.2014.02.002     Document Type: Article
Times cited : (23)

References (44)
  • 1
    • 0025122409 scopus 로고
    • Detection of subclinical nasopharyngeal carcinoma by fiber optic endoscopy and multiple biopsy
    • Sham J.S., Wei W.I., Zong Y.S., et al. Detection of subclinical nasopharyngeal carcinoma by fiber optic endoscopy and multiple biopsy. Lancet 1990, 335:371-374.
    • (1990) Lancet , vol.335 , pp. 371-374
    • Sham, J.S.1    Wei, W.I.2    Zong, Y.S.3
  • 2
    • 0036435155 scopus 로고    scopus 로고
    • Epidemiology of nasopharyngeal carcinoma
    • Yu M.C., Yuan J.M. Epidemiology of nasopharyngeal carcinoma. Semin Cancer Biol 2002, 12:421-429.
    • (2002) Semin Cancer Biol , vol.12 , pp. 421-429
    • Yu, M.C.1    Yuan, J.M.2
  • 4
    • 33846686733 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma
    • Brennan B. Nasopharyngeal carcinoma. Orphanet J Rare Dis 2006, 1:23.
    • (2006) Orphanet J Rare Dis , vol.1 , pp. 23
    • Brennan, B.1
  • 5
    • 0031003112 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virus
    • Vasef M.A., Ferlito A., Weiss L.M. Nasopharyngeal carcinoma, with emphasis on its relationship to Epstein-Barr virus. Ann Otol Rhinol Laryngol 1997, 106:348-356.
    • (1997) Ann Otol Rhinol Laryngol , vol.106 , pp. 348-356
    • Vasef, M.A.1    Ferlito, A.2    Weiss, L.M.3
  • 6
    • 0026647880 scopus 로고
    • Carcinoma of the nasopharynx. Analysis of treatment results in 167 consecutively admitted patients
    • Johansen L.V., Mestre M., Overgaard J. Carcinoma of the nasopharynx. Analysis of treatment results in 167 consecutively admitted patients. Head Neck 1992, 14:200-207.
    • (1992) Head Neck , vol.14 , pp. 200-207
    • Johansen, L.V.1    Mestre, M.2    Overgaard, J.3
  • 7
    • 6344237620 scopus 로고    scopus 로고
    • Recent advances in the treatment of nasopharyngeal carcinoma
    • Chang J.T., Ko J.Y., Hong R.L. Recent advances in the treatment of nasopharyngeal carcinoma. J Formosan Med Assoc 2004, 103:496-510.
    • (2004) J Formosan Med Assoc , vol.103 , pp. 496-510
    • Chang, J.T.1    Ko, J.Y.2    Hong, R.L.3
  • 8
    • 0030917999 scopus 로고    scopus 로고
    • Carcinoma of the nasopharynx treated by radiotherapy alone. Determinants of local and regional control
    • Sanguineti G., Geara F.B., Garden A.S., et al. Carcinoma of the nasopharynx treated by radiotherapy alone. Determinants of local and regional control. Int J Radiat Oncol Biol Phys 1997, 37:985-996.
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 985-996
    • Sanguineti, G.1    Geara, F.B.2    Garden, A.S.3
  • 9
    • 0031947875 scopus 로고    scopus 로고
    • Chemoradiotherapy vs. radiotherapy in patients with advanced nasopharyngeal cáncer: phase III randomized Intergroup study 0099
    • Al-Sarraf M., LeBlanc M., Giri P.G., et al. Chemoradiotherapy vs. radiotherapy in patients with advanced nasopharyngeal cáncer: phase III randomized Intergroup study 0099. J Clin Oncol 1998, 16:1310-1317.
    • (1998) J Clin Oncol , vol.16 , pp. 1310-1317
    • Al-Sarraf, M.1    LeBlanc, M.2    Giri, P.G.3
  • 10
    • 77954219503 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma: the next challenges
    • Razak A.R., Siu L.L., Liu F.F., et al. Nasopharyngeal carcinoma: the next challenges. Eur J Cancer 2010, 46:1967-1978.
    • (2010) Eur J Cancer , vol.46 , pp. 1967-1978
    • Razak, A.R.1    Siu, L.L.2    Liu, F.F.3
  • 11
    • 0036435157 scopus 로고    scopus 로고
    • The significance of LMP1 expression in nasopharyngeal carcinoma
    • Tsao S.W., Tramoutanis G., Dawson C.W., et al. The significance of LMP1 expression in nasopharyngeal carcinoma. Semin Cancer Biol 2002, 12:473-487.
    • (2002) Semin Cancer Biol , vol.12 , pp. 473-487
    • Tsao, S.W.1    Tramoutanis, G.2    Dawson, C.W.3
  • 12
    • 0025325578 scopus 로고
    • Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6
    • Wilson J.B., Weinberg W., Johnson R., et al. Expression of the BNLF-1 oncogene of Epstein-Barr virus in the skin of transgenic mice induces hyperplasia and aberrant expression of keratin 6. Cell 1990, 61:1315-1317.
    • (1990) Cell , vol.61 , pp. 1315-1317
    • Wilson, J.B.1    Weinberg, W.2    Johnson, R.3
  • 13
    • 56349087017 scopus 로고    scopus 로고
    • Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes
    • Morris M.A., Dawson C.W., Wei W., et al. Epstein-Barr virus-encoded LMP1 induces a hyperproliferative and inflammatory gene expression programme in cultured keratinocytes. J Gen Virol 2008, 89:2806-2820.
    • (2008) J Gen Virol , vol.89 , pp. 2806-2820
    • Morris, M.A.1    Dawson, C.W.2    Wei, W.3
  • 14
    • 70349210826 scopus 로고    scopus 로고
    • Role of the Epstein-Barr virus-encoded latent membrane protein 1, LMP1, in the pathogenesis of nasopharyngeal carcinoma
    • Morris M.A., Dawson C.W., Young L.S. Role of the Epstein-Barr virus-encoded latent membrane protein 1, LMP1, in the pathogenesis of nasopharyngeal carcinoma. Future Oncol 2009, 5:811-825.
    • (2009) Future Oncol , vol.5 , pp. 811-825
    • Morris, M.A.1    Dawson, C.W.2    Young, L.S.3
  • 15
    • 84857790848 scopus 로고    scopus 로고
    • The role of the EBV-encoded latentmembrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC)
    • Dawson C.W., Port R.J., Young L.S. The role of the EBV-encoded latentmembrane proteins LMP1 and LMP2 in the pathogenesis of nasopharyngeal carcinoma (NPC). Semin Cancer Biol 2012, 22:144-153.
    • (2012) Semin Cancer Biol , vol.22 , pp. 144-153
    • Dawson, C.W.1    Port, R.J.2    Young, L.S.3
  • 18
    • 1842632666 scopus 로고    scopus 로고
    • Nasopharyngeal carcinomas and Epstein-Barr virus: from epidemiology and detection to therapy
    • Busson P., Ooka T., Corbex M. Nasopharyngeal carcinomas and Epstein-Barr virus: from epidemiology and detection to therapy. Med Sci (Paris) 2004, 20:453-457.
    • (2004) Med Sci (Paris) , vol.20 , pp. 453-457
    • Busson, P.1    Ooka, T.2    Corbex, M.3
  • 19
    • 33846516389 scopus 로고    scopus 로고
    • Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology
    • Ou S.H., Zell J.A., Ziogas A., et al. Epidemiology of nasopharyngeal carcinoma in the United States: improved survival of Chinese patients within the keratinizing squamous cell carcinoma histology. Ann Oncol 2007, 18:29-35.
    • (2007) Ann Oncol , vol.18 , pp. 29-35
    • Ou, S.H.1    Zell, J.A.2    Ziogas, A.3
  • 20
    • 0033257370 scopus 로고    scopus 로고
    • Nasopharyngeal carcinoma
    • Wenig B.M. Nasopharyngeal carcinoma. Ann Diagn Pathol 1999, 3:374-385.
    • (1999) Ann Diagn Pathol , vol.3 , pp. 374-385
    • Wenig, B.M.1
  • 22
    • 0028918208 scopus 로고
    • Prognostic significance of keratinization in nasopharyngeal carcinoma
    • Reddy S.P., Raslan W.F., Gooneratne S., et al. Prognostic significance of keratinization in nasopharyngeal carcinoma. Am J Otolaryngol 1995, 16:103-108.
    • (1995) Am J Otolaryngol , vol.16 , pp. 103-108
    • Reddy, S.P.1    Raslan, W.F.2    Gooneratne, S.3
  • 23
    • 84859961543 scopus 로고    scopus 로고
    • The prognostic value of histological typing in nasopharyngeal carcinoma
    • Cheung F., Chan O., Tong-Ng W., et al. The prognostic value of histological typing in nasopharyngeal carcinoma. Oral Oncol 2012, 48:429-433.
    • (2012) Oral Oncol , vol.48 , pp. 429-433
    • Cheung, F.1    Chan, O.2    Tong-Ng, W.3
  • 24
    • 0036534384 scopus 로고    scopus 로고
    • Molecular pathology parameters in human nasopharyngeal carcinoma
    • Shi W., Pataki I., MacMillan C., et al. Molecular pathology parameters in human nasopharyngeal carcinoma. Cancer 2002, 94:1997-2006.
    • (2002) Cancer , vol.94 , pp. 1997-2006
    • Shi, W.1    Pataki, I.2    MacMillan, C.3
  • 25
    • 33750338001 scopus 로고    scopus 로고
    • Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer
    • Yip K.W., Shi W., Pintilie M., et al. Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer. Clin Cancer Res 2006, 12:5726-5732.
    • (2006) Clin Cancer Res , vol.12 , pp. 5726-5732
    • Yip, K.W.1    Shi, W.2    Pintilie, M.3
  • 26
    • 84873904977 scopus 로고    scopus 로고
    • Current and emerging treatment options for nasopharyngeal carcinoma
    • Spratt D.E., Lee N. Current and emerging treatment options for nasopharyngeal carcinoma. OncoTargets Therapy 2012, 5:297-308.
    • (2012) OncoTargets Therapy , vol.5 , pp. 297-308
    • Spratt, D.E.1    Lee, N.2
  • 27
    • 56949099838 scopus 로고    scopus 로고
    • Multiple roles of LMP1 in Epstein-Barr virus induced immune escape
    • Middeldorp J.M., Pegtel D.M. Multiple roles of LMP1 in Epstein-Barr virus induced immune escape. Semin Cancer Biol 2008, 18:388-396.
    • (2008) Semin Cancer Biol , vol.18 , pp. 388-396
    • Middeldorp, J.M.1    Pegtel, D.M.2
  • 28
    • 42549160064 scopus 로고    scopus 로고
    • Expression of immune-related molecules in primary EBV-positive Chinese nasopharyngeal carcinoma: associated with latent membrane protein 1 (LMP1)
    • Li J., Zhang X.S., Xie D., et al. Expression of immune-related molecules in primary EBV-positive Chinese nasopharyngeal carcinoma: associated with latent membrane protein 1 (LMP1). Cancer Biol Ther 2007, 6:1997-2004.
    • (2007) Cancer Biol Ther , vol.6 , pp. 1997-2004
    • Li, J.1    Zhang, X.S.2    Xie, D.3
  • 29
    • 0028001170 scopus 로고
    • Epstein-Barr virus and Hodgkin's disease: a comparative immunological, in situ hybridization, and polymerase chain reaction study
    • Lauritzen A.F., Hording U., Nielsen H.W. Epstein-Barr virus and Hodgkin's disease: a comparative immunological, in situ hybridization, and polymerase chain reaction study. APMIS 1994, 102:495-500.
    • (1994) APMIS , vol.102 , pp. 495-500
    • Lauritzen, A.F.1    Hording, U.2    Nielsen, H.W.3
  • 30
    • 84873817705 scopus 로고    scopus 로고
    • Comparison of three methods for the detection of Epstein-Barr virus in Hodgkin's lymphoma in paraffin-embedded tissues
    • Qi Z.L., Han X.Q., Hu J., et al. Comparison of three methods for the detection of Epstein-Barr virus in Hodgkin's lymphoma in paraffin-embedded tissues. Mol Med Rep 2013, 7:89-92.
    • (2013) Mol Med Rep , vol.7 , pp. 89-92
    • Qi, Z.L.1    Han, X.Q.2    Hu, J.3
  • 31
    • 33749358055 scopus 로고    scopus 로고
    • Recombinant adeno-associated virus mediated RNA interference inhibits metastasis of nasopharyngeal cancer cells invivo and invitro by suppression of Epstein-Barr virus encoded LMP-1
    • Li X., Liu X., Ding Y., et al. Recombinant adeno-associated virus mediated RNA interference inhibits metastasis of nasopharyngeal cancer cells invivo and invitro by suppression of Epstein-Barr virus encoded LMP-1. Int J Oncol 2006, 29:595-603.
    • (2006) Int J Oncol , vol.29 , pp. 595-603
    • Li, X.1    Liu, X.2    Ding, Y.3
  • 32
    • 78650684724 scopus 로고    scopus 로고
    • LMP1 and LMP2 may be prognostic factors for outcome of therapy in nasopharyngeal cancers in Indonesia
    • Hariwiyanto B., Sastrowiyoto S., Mubarika S., et al. LMP1 and LMP2 may be prognostic factors for outcome of therapy in nasopharyngeal cancers in Indonesia. Asian Pac J Cancer Prev 2010, 11:763-766.
    • (2010) Asian Pac J Cancer Prev , vol.11 , pp. 763-766
    • Hariwiyanto, B.1    Sastrowiyoto, S.2    Mubarika, S.3
  • 33
    • 18644368754 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma
    • Kondo S., Wakisaka N., Schell M.J., et al. Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma. Int J Cancer 2005, 115:368-376.
    • (2005) Int J Cancer , vol.115 , pp. 368-376
    • Kondo, S.1    Wakisaka, N.2    Schell, M.J.3
  • 34
    • 0029011016 scopus 로고
    • Differences in the growth pattern and clinical course of EBV LMP1 expressing and non-expressing nasopharyngeal carcinomas
    • Hu L.F., Chen F., Zhen Q.F., et al. Differences in the growth pattern and clinical course of EBV LMP1 expressing and non-expressing nasopharyngeal carcinomas. Eur J Cancer 1995, 31:658-660.
    • (1995) Eur J Cancer , vol.31 , pp. 658-660
    • Hu, L.F.1    Chen, F.2    Zhen, Q.F.3
  • 35
    • 3042742121 scopus 로고    scopus 로고
    • Molecular characterization of Epstein-Barr virus and oncoprotein expression in nasopharyngeal carcinoma in Korea
    • Jeon Y.K., Lee B.Y., Kim J.E., et al. Molecular characterization of Epstein-Barr virus and oncoprotein expression in nasopharyngeal carcinoma in Korea. Head Neck 2004, 26:573-583.
    • (2004) Head Neck , vol.26 , pp. 573-583
    • Jeon, Y.K.1    Lee, B.Y.2    Kim, J.E.3
  • 36
    • 84355161630 scopus 로고    scopus 로고
    • LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis
    • Zhao Y., Wang Y., Zeng S., et al. LMP1 expression is positively associated with metastasis of nasopharyngeal carcinoma: evidence from a meta-analysis. J Clin Pathol 2012, 65:41-45.
    • (2012) J Clin Pathol , vol.65 , pp. 41-45
    • Zhao, Y.1    Wang, Y.2    Zeng, S.3
  • 37
    • 45849121783 scopus 로고    scopus 로고
    • Prognostic influence of parapharyngeal extension in nasopharyngeal carcinoma
    • Ho H.C., Lee M.S., Hsiao S.H., et al. Prognostic influence of parapharyngeal extension in nasopharyngeal carcinoma. Acta Otolaryngol 2008, 128:790-798.
    • (2008) Acta Otolaryngol , vol.128 , pp. 790-798
    • Ho, H.C.1    Lee, M.S.2    Hsiao, S.H.3
  • 38
    • 43949113261 scopus 로고    scopus 로고
    • DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma
    • Lu Z.X., Ma W.Q., Yang L.F., et al. DNAzymes targeted to EBV-encoded latent membrane protein-1 induce apoptosis and enhance radiosensitivity in nasopharyngeal carcinoma. Cancer Lett 2008, 265:226-238.
    • (2008) Cancer Lett , vol.265 , pp. 226-238
    • Lu, Z.X.1    Ma, W.Q.2    Yang, L.F.3
  • 39
    • 80655132010 scopus 로고    scopus 로고
    • Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-κB regulated ATM expression
    • Ma X., Yang L., Xiao L., et al. Down-regulation of EBV-LMP1 radio-sensitizes nasal pharyngeal carcinoma cells via NF-κB regulated ATM expression. PLoS One 2011, 6:e24647.
    • (2011) PLoS One , vol.6
    • Ma, X.1    Yang, L.2    Xiao, L.3
  • 40
    • 0035236993 scopus 로고    scopus 로고
    • Reduced expression of p16 and p27 proteins in nasopharyngeal carcinoma
    • Baba Y., Tsukuda M., Mochimatsu I., et al. Reduced expression of p16 and p27 proteins in nasopharyngeal carcinoma. Cancer Detect Prev 2001, 25:414-419.
    • (2001) Cancer Detect Prev , vol.25 , pp. 414-419
    • Baba, Y.1    Tsukuda, M.2    Mochimatsu, I.3
  • 41
    • 0035835818 scopus 로고    scopus 로고
    • P16(MTS-1/CDKN2/INK4a) in cancer progression
    • Rocco J.W., Sidransky D. p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res 2001, 264:42-55.
    • (2001) Exp Cell Res , vol.264 , pp. 42-55
    • Rocco, J.W.1    Sidransky, D.2
  • 42
    • 84855221343 scopus 로고    scopus 로고
    • Differences between oral cancer and cancers of the pharynx and larynx on a molecular level
    • Shiga K., Ogawa T., Katagiri K., et al. Differences between oral cancer and cancers of the pharynx and larynx on a molecular level. Oncol Lett 2012, 3:238-243.
    • (2012) Oncol Lett , vol.3 , pp. 238-243
    • Shiga, K.1    Ogawa, T.2    Katagiri, K.3
  • 43
    • 0033955571 scopus 로고    scopus 로고
    • Absence of nuclear p16 from Epstein-Barr virus-associated undifferentiated nasopharyngeal carcinomas
    • Shibosawa E., Tsutsumi K., Koizuka I., et al. Absence of nuclear p16 from Epstein-Barr virus-associated undifferentiated nasopharyngeal carcinomas. Laryngoscope 2000, 110:93-97.
    • (2000) Laryngoscope , vol.110 , pp. 93-97
    • Shibosawa, E.1    Tsutsumi, K.2    Koizuka, I.3
  • 44
    • 35348969475 scopus 로고    scopus 로고
    • The clinical significance of p16 protein non-expression and p16 gene inactivation by deletions and hypermethylation in nasopharyngeal carcinoma
    • Xiang Y.N., Zhang W.Y. The clinical significance of p16 protein non-expression and p16 gene inactivation by deletions and hypermethylation in nasopharyngeal carcinoma. Zhonghua Bing Li Xue Za Zhi 2005, 34:358-361.
    • (2005) Zhonghua Bing Li Xue Za Zhi , vol.34 , pp. 358-361
    • Xiang, Y.N.1    Zhang, W.Y.2


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