Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-Mediated IFN-β production during streptococcus pneumoniae infection

Journal of Immunology

Volumn 192, Issue 9, 2014, Pages 4273-4283

  Mitzel, Dana N ^a   Lowry, Virginia ^a   Shirali, Anushree C ^b   Liu, Yushi ^a   Stout Delgado, Heather W ^a  

^a LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; AUTOPHAGY RELATED GENE 9 PROTEIN; BETA INTERFERON; CELL PROTEIN; GEMCITABINE; INOSITOL; INTERFERON; PROTEIN STING; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ADULT; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; CELL AGING; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOPLASMIC RETICULUM STRESS; FEMALE; HOST PATHOGEN INTERACTION; IFN GENE; IMMUNOSTIMULATION; IN VIVO STUDY; LUNG PARENCHYMA; MACROPHAGE FUNCTION; MALE; MORBIDITY; MORTALITY; MOUSE; NONHUMAN; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS;

AGING; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; ENDOPLASMIC RETICULUM STRESS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNOPRECIPITATION; INTERFERON-BETA; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PNEUMOCOCCAL INFECTIONS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84899511509     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1303090     Document Type: Article

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