Upregulation of the insulin receptor and type i insulin-like growth factor receptor are early events in hepatocarcinogenesis

Toxicologic Pathology

Volumn 39, Issue 3, 2011, Pages 524-543

  Aleem, Eiman ^a,b   Nehrbass, Dirk ^a,c   Klimek, Fritz ^a   Mayer, Doris ^a   Bannasch, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Alexandria University Faculty Of Science   (Egypt)

^c AO RESEARCH INSTITUTE   (Switzerland)

Author keywords

hepatocellular carcinoma; insulin receptor; insulin receptor substrate 2; mitogen activated extracellular regulated kinase 1; preneoplastic glycogenotic foci; type 1 insulin like growth factor receptor

Indexed keywords

GLYCOGEN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; NITROSOMORPHOLINE; SOMATOMEDIN C RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; GLYCOGEN STORAGE FOCUS; GLYCOGENOLYSIS; LIVER CARCINOGENESIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; MAP KINASE KINASE 1; NITROSAMINES; PRECANCEROUS CONDITIONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; UP-REGULATION;

EID: 79955553768     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623310396905     Document Type: Article

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