Analysis of HOX gene expression patterns in human breast cancer

Molecular Biotechnology

Volumn 56, Issue 1, 2014, Pages 64-71

  Hur, Ho ^a,b   Lee, Ji Yeon ^b   Yun, Hyo Jung ^b   Park, Byeong Woo ^b   Kim, Myoung Hee ^b  

^a National Health Insurance Corporation   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

Author keywords

Breast cancer; Cell lines; Expression analysis; HOX; Malignant breast tissue; Normal breast tissue

Indexed keywords

CELL CULTURE; CELLS; DISEASES; HISTOLOGY; TISSUE ENGINEERING; TUMORS;

BREAST CANCER; BREAST TISSUES; CELL LINES; EXPRESSION ANALYSIS; HOX;

GENE EXPRESSION;

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR;

ARTICLE; BREAST; BREAST CANCER; BREAST CARCINOMA; BREAST FIBROADENOMA; BREAST PAPILLOMA; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HOX GENE; HOXA GENE; HOXB GENE; HOXC GENE; HOXD GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PAPILLOMATOSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

BREAST NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, HOMEOBOX; HOMEODOMAIN PROTEINS; HUMANS; MCF-7 CELLS; TUMOR CELLS, CULTURED;

EID: 84899482814     PISSN: 10736085     EISSN: 15590305     Source Type: Journal    
DOI: 10.1007/s12033-013-9682-4     Document Type: Article

References (25)

1. Rao, R. D., & Cobleigh, M. A. (2012). Adjuvant endocrine therapy for breast cancer. Oncology, 26, 541-547.
2. Slamon, D., Eiermann, W., Robert, N., Pienkowski, T., Martin, M., Press, M., et al. (2011). Adjuvant trastuzumab in HER2-positive breast cancer. New England Journal of Medicine, 365, 1273-1283.
3. Giuliano, M., Schifp, R., Osborne, C. K., & Trivedi, M. V. (2011). Biological mechanisms and clinical implications of endocrine resistance in breast cancer. Breast, S3, S42-S49.
4. Rexer, B. N., & Arteaga, C. L. (2012). Intrinsic and acquired resistance to HER2-targeted therapies in HER2 gene-amplified breast cancer: Mechanisms and clinical implications. Critical Reviews in Oncogenesis, 17, 1-16.
5. Mann, R. S., & Affolter, M. (1998). Hox proteins meet more partners. Current Opinion in Genetics & Development, 8, 423-429. (Pubitemid 28412459)
6. Favier, B., & Dollé, P. (1997). Developmental functions of mammalian Hox genes. Molecular Human Reproduction, 3, 115-131. (Pubitemid 127509441)
7. Shah, N., & Sukumar, S. (2010). The Hox genes and their roles in oncogenesis. Nature Reviews Cancer, 10, 361-371.
8. Svingen, T., & Tonissen, K. F. (2003). Altered HOX gene expression in human skin and breast cancer cells. Cancer Biology & Therapy, 2, 518-523.
9. Cantile, M., Procino, A., Feliciello, I., Cindolo, L., & Cillo, C. (2003). In vivo expression of the whole HOX gene network in human breast cancer. European Journal of Cancer, 39, 257-264. (Pubitemid 36057077)
10. Makiyama, K., Hamada, J., Takada, M., Murakawa, K., Takahashi, Y., Tada, M., et al. (2005). Aberrant expression of HOX genes in human invasive breast carcinoma. Oncology Reports, 13, 673-679.
11. Raman, V., Martensen, S. A., Reisman, D., Evron, E., Odenwald, W. F., Jaffee, E., et al. (2000). Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature, 405, 974-978. (Pubitemid 30435057)
12. Gilbert, P. M., Mouw, J. K., Unger, M. A., Lakins, J. N., Gbegnon, M. K., Clemmer, V. B., et al. (2010). HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. Journal of Clinical Investigation, 120, 1535-1550.
13. Care, A., Silvani, A., Meccia, E., Mattia, G., Peschle, C., & Colombo, M. P. (1998). Transduction of the SkBr3 breast carcinoma cell line with the HOXB7 gene induces bFGF expression, increases cell proliferation and reduces growth factor dependence. Oncogene, 16, 3285-3289. (Pubitemid 28330427)
14. Jin, K., Kong, X., Shah, T., Penet, M. F., Wildes, F., Sgroi, D. C., et al. (2012). The HOXB7 protein renders breast cancer cells resistant to tamoxifen through activation of the EGFR pathway. Proceedings of the National Academy of Sciences of the United States of America, 109, 2736-2741.
15. Carè, A., Felicetti, F., Meccia, E., Bottero, L., Parenza, M., Stoppacciaro, A., et al. (2001). HOXB7: A key factor for tumor-associated angiogenic switch. Cancer Research, 61, 6532-6539. (Pubitemid 32783261)
16. Hayashida, T., Takahashi, F., Chiba, N., Brachtel, E., Takahashi, M., Godin-Heymann, N., et al. (2010). HOXB9, a gene overexpressed in breast cancer, promotes tumorigenicity and lung metastasis. Proceedings of the National Academy of Sciences of the United States of America, 107, 1100-1105.
17. Zhang, X., Zhu, T., Chen, Y., Mertani, H. C., Lee, K. O., & Lobie, P. E. (2003). Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene. Journal of Biological Chemistry, 278, 7580-7590. (Pubitemid 36800766)
18. Shaoqiang, C., Yue, Z., Yang, L., Hong, Z., Lina, Z., Da, P., et al. (2013). Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer. Clinical & Experimental Metastasis, 30, 155-163.
19. Rodriguez, B. A., Cheng, A. S., Yan, P. S., Potter, D., Agosto-Perez, F. J., Shapiro, C. L., et al. (2008). Epigenetic repression of the estrogen-regulated Homeobox B13 gene in breast cancer. Carcinogenesis, 29, 1459-1465.
20. Kao, J., Salari, K., Bocanegra, M., Choi, Y. L., Girard, L., Gandhi, J., et al. (2009). Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One, 4, e6146.
21. Neve, R. M., Chin, K., Fridlyand, J., Yeh, J., Baehner, F. L., Fevr, T., et al. (2006). A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell, 10, 515-527. (Pubitemid 44854747)
22. Hsiao, Y. H., Chou, M. C., Fowler, C., Mason, J. T., & Man, Y. G. (2010). Breast cancer heterogeneity: Mechanisms, proofs, and implications. Journal of Cancer, 1, 6-13.
23. Morgan, R., Boxall, A., Harrington, K. J., Simpson, G. R., Gillett, C., Michael, A., et al. (2012). Targeting the HOX/PBX dimer in breast cancer. Breast Cancer Research and Treatment, 136, 389-398.
24. Di Pietro, M., Lao-Sirieix, P., Boyle, S., Cassidy, A., Castillo, D., Saadi, A., et al. (2012). Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus. Proceedings of the National Academy of Sciences of the United States of America, 109, 9077-9082.
25. Boimel, P. J., Cruz, C., & Segall, J. E. (2011). A functional in vivo screen for regulators of tumor progression identifies HOXB2 as a regulator of tumor growth in breast cancer. Genomics, 98, 164-172.