Evidence for a functional role of epigenetically regulated midcluster HOXB genes in the development of Barrett esophagus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 23, 2012, Pages 9077-9082

  Di Pietro, Massimiliano ^a   Lao Sirieix, Pierre ^a   Boyle, Shelagh ^b   Cassidy, Andy ^c   Castillo, Dani ^d   Saadi, Amel ^c   Eskeland, Ragnhild ^b,e   Fitzgerald, Rebecca C ^a  

^a HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c Li Ka Shing Centre   (United Kingdom)

^d HOSPITAL DEL MAR   (Spain)

^e UNIVERSITY OF OSLO   (Norway)

Author keywords

Cancer; Chromatin compaction; Epigenetics; Homeobox; Metaplasia

Indexed keywords

GLYCOPROTEIN; HOX PROTEIN; HOXB PROTEIN; HOXB5 PROTEIN; HOXB6 PROTEIN; HOXB7 PROTEIN; KRT20 PROTEIN; MUCIN 2; UNCLASSIFIED DRUG; VILLIN;

ANIMAL CELL; ARTICLE; BARRETT ESOPHAGUS; CARDIA; CELL DIFFERENTIATION; COLON MUCOSA; CONTROLLED STUDY; EPIGENETICS; GAIN OF FUNCTION MUTATION; GENE CLUSTER; GENE LOCUS; GENE OVEREXPRESSION; GENETIC ASSOCIATION; HISTONE MODIFICATION; HOX GENE; IN VITRO STUDY; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING;

ADENOCARCINOMA; ADULT; BARRETT ESOPHAGUS; BLOTTING, WESTERN; CHROMATIN IMMUNOPRECIPITATION; COLON; DNA PRIMERS; EPIGENESIS, GENETIC; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, HOMEOBOX; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICROARRAY ANALYSIS; POLYMERASE CHAIN REACTION;

ANIMALIA;

EID: 84861880604     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1116933109     Document Type: Article

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