Impaired relaxation despite upregulated calcium-handling protein atrial myocardium from type 2 diabetic patients with preserved ejection fraction

Cardiovascular Diabetology

Volumn 13, Issue 1, 2014, Pages

  Lamberts, Regis R ^a   Lingam, Shivanjali J ^a   Wang, Heng Yu ^a   Bollen, Ilse A E ^a   Hughes, Gillian ^a   Galvin, Ivor F ^b   Bunton, Richard W ^b   Bahn, Andrew ^a   Katare, Rajesh ^a   Baldi, J C ^b   Williams, Michael J A ^b   Saxena, Pankaj ^b   Coffey, Sean ^b   Jones, Peter P ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b DUNEDIN HOSPITAL   (New Zealand)

Author keywords

Adrenergic regulation; Calcium signaling; Contraction; Diastolic dysfunction; Human myocardium; Myocardial fibrosis; Relaxation; Type 2 diabetes

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; CALCIUM HANDLING PROTEIN; COLLAGEN; PHOSPHOLAMBAN; PROTEIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

AGED; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DIABETIC PATIENT; DISEASE ASSOCIATION; FEMALE; HEART ATRIUM APPENDAGE; HEART ATRIUM CONTRACTION; HEART EJECTION FRACTION; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART MUSCLE RELAXATION; HUMAN; HUMAN TISSUE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PICRO SIRIUS RED STAINING; PRESERVED EJECTION FRACTION; PROTEIN CONTENT; PROTEIN EXPRESSION; STAINING; SYSTOLE; UPREGULATION; WESTERN BLOTTING;

AGED; CALCIUM; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; HEART ATRIA; HUMANS; MALE; MYOCARDIUM; ORGAN CULTURE TECHNIQUES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STROKE VOLUME; UP-REGULATION; VASODILATION;

EID: 84899472094     PISSN: None     EISSN: 14752840     Source Type: Journal    
DOI: 10.1186/1475-2840-13-72     Document Type: Article

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