Applications of surface-enhanced Raman scattering in advanced bio-medical technologies and diagnostics

Drug Metabolism Reviews

Volumn 46, Issue 2, 2014, Pages 155-175

  Nima, Zeid A ^a   Biswas, Abhijit ^b   Bayer, Ilker S ^c   Hardcastle, Franklin D ^d   Perry, Donald ^e   Ghosh, Anindya ^f   Dervishi, Enkeleda ^a,g   Biris, Alexandru S ^a  

^a UNIVERSITY OF ARKANSAS AT LITTLE ROCK   (United States)

^b University of Notre Dame   (United States)

^c ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^d ARKANSAS TECH UNIVERSITY   (United States)

^e UNIVERSITY OF CENTRAL ARKANSAS   (United States)

^f Department of Chemistry University of Arkansas at Little Rock ^*  (United States)

^g LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

Biomedical applications; Cancer cell detection; Surface enhanced Raman spectroscopy

Indexed keywords

DNA; IMMUNOGLOBULIN; RNA; NANOPARTICLE;

ACCURACY; ANALYTIC METHOD; BACTERIUM DETECTION; BIOMEDICINE; CANCER DIAGNOSIS; COMPUTER PROGRAM; DIAGNOSTIC IMAGING; MEDICAL TECHNOLOGY; NANOFLUIDICS; NEOPLASM; PROTEIN ANALYSIS; RAMAN SPECTROMETRY; REVIEW; THEORETICAL MODEL; COMPUTER ASSISTED DIAGNOSIS; DEVICES; DIAGNOSTIC EQUIPMENT; DIAGNOSTIC USE; EQUIPMENT DESIGN; HUMAN; MOLECULAR DIAGNOSIS; NEOPLASMS; PROCEDURES; SURFACE PLASMON RESONANCE; TRENDS;

BIOMEDICAL TECHNOLOGY; DIAGNOSIS, COMPUTER-ASSISTED; DIAGNOSTIC EQUIPMENT; EQUIPMENT DESIGN; HUMANS; MODELS, THEORETICAL; MOLECULAR DIAGNOSTIC TECHNIQUES; NANOPARTICLES; NEOPLASMS; SPECTRUM ANALYSIS, RAMAN; SURFACE PLASMON RESONANCE;

EID: 84899456847     PISSN: 03602532     EISSN: 10979883     Source Type: Journal    
DOI: 10.3109/03602532.2013.873451     Document Type: Review

References (134)

1. Abdali S, De Laere B, Poulsen M, et al. (2010). Toward methodology for detection of cancer-promoting S100A4 protein conformations in subnanomolar concentrations using Raman and SERS. J Phys Chem C 114: 7274-7279.
2. Ahern AM, Garrell RL. (1987). In situ photoreduced silver nitrate as a substrate for surface-enhanced Raman spectroscopy. Anal Chem 59: 2813-2816.
3. Albrecht MG, Creighton JA. (1977). Anomalously intense Raman spectra of pyridine at a silver electrode. J Am Chem Soc 99: 5215-5217.
4. Andrade GF, Fan M, Brolo AG. (2010). Multilayer silver nanoparticlesmodified optical fiber tip for high performance SERS remote sensing. Biosens Bioelectron 25: 2270-2275.
5. Anker JN, Hall WP, Lyandres O, et al. (2008). Biosensing with plasmonic nanosensors. Nat Mater 7: 442-453.
6. Aroca R. (2007). Front matter. Surface-enhanced vibrational spectroscopy. John Wiley & Sons, Ltd, i-xxv.
7. Benford ME, Wang M, Kameoka J, et al. (2009). Detection of cardiac biomarkers exploiting surface enhanced Raman scattering (SERS) using a nanofluidic channel based biosensor towards coronary pointof- care diagnostics. In: Vo-Dinh T, Lakowicz JR, eds. Plasmonics in biology and medicine VI. 1st ed. San Jose (CA): SPIE, 719203-719206.
8. Berthod A, Laserna JJ, Winefordner JD. (1987). Surface enhanced Raman spectrometry on silver hydrosols studied by flow injection analysis. Appl Spectrosc 41: 1137-1141.
9. Biswas A, Bayer IS, Dahanayaka DH, et al. (2009). Tailored polymer- metal fractal nanocomposites: An approach to highly active surface enhanced Raman scattering substrates. Nanotechnology 20: 325705-325711.
10. Cam D, Keseroglu K, Kahraman M, et al. (2010). Multiplex identification of bacteria in bacterial mixtures with surface-enhanced Raman scattering. J Raman Spectrosc 41: 484-489.
11. Camden JP, Dieringer JA, Zhao J, et al. (2008). Controlled plasmonic nanostructures for surface-enhanced spectroscopy and sensing. Acc Chem Res 41: 1653-1661.
12. Campion A, Kambhampati P. (1998). Surface-enhanced Raman scattering. Chem Soc Rev 27: 241-250.
13. Chang RK, Furtak TE. (1982). Surface enhanced Raman scattering. New York: Plenum Press.
14. Chen L, Luo L, Chen Z, et al. (2009). ZnO/Au composite nanoarrays as substrates for surface-enhanced raman scattering detection. J Phys Chem C 114: 93-100.
15. Cheng H-W, Huan S-Y, Wu H-L, et al. (2009). Surface-enhanced Raman spectroscopic detection of a bacteria biomarker using gold nanoparticle immobilized substrates. Anal Chem 81: 9902-9912.
16. Chernenko T, Sawant RR, Miljkovic M, et al. (2012). Raman microscopy for noninvasive imaging of pharmaceutical nanocarriers: Intracellular distribution of cationic liposomes of different composition. Mol Pharma 9: 930-936.
17. Choi I, Huh Y, Erickson D. (2012). Ultra-sensitive, label-free probing of the conformational characteristics of amyloid beta aggregates with a SERS active nanofluidic device. Microfluid Nanofluid 12: 663-669.
18. Choi I, Huh YS, Erickson D. (2011). Size-selective concentration and label-free characterization of protein aggregates using a Raman active nanofluidic device. Lab Chip 11: 632-638.
19. Choi J-Y, Kim K, Shin KS. (2010). Surface-enhanced Raman scattering inducible by recyclable Ag-coated magnetic particles. Vibrat Spectrosc 53: 117-120.
20. Chou IH, Benford M, Beier HT, et al. (2008). Nanofluidic biosensing for beta-amyloid detection using surface enhanced Raman spectroscopy. Nano Lett 8: 1729-1735.
21. Chu Y, Banaee MG, Crozier KB. (2010). Double-resonance plasmon substrates for surface-enhanced Raman scattering with enhancement at excitation and stokes frequencies. ACS Nano 4: 2804-2810.
22. Ciurlea SA, Dehelean C, Ionescu D, et al. (2009). SERS technique and its applications for toxicological evaluations in experimental breast cancer. Toxicol Lett 189:S132.
23. Cordova S, Schiefer E, Bonde A, et al. (2010). Impact of choice of alkane deposition solvent on 4-fluorobenzoic acid layers adsorbed on silver nanostructures. Chem Phys Lett 497: 52-56.
24. Creighton JA, Blatchford CG, Albrecht MG. (1979). Plasma resonance enhancement of Raman scattering by pyridine adsorbed on silver or gold sol particles of size comparable to the excitation wavelength. J Chem Soc Faraday Trans 2 Mol Chem Phys 75: 790-798.
25. Das G, Mecarini F, Gentile F, et al. (2009). Nano-patterned SERS substrate: Application for protein analysis vs. temperature. Biosens Bioelectron 24: 1693-1699.
26. Driskell JD, Seto AG, Jones LP, et al. (2008). Rapid microRNA (miRNA) detection and classification via surface-enhanced Raman spectroscopy (SERS). Biosens Bioelectron 24: 917-922.
27. Driskell JD, Uhlenkamp JM, Lipert RJ, et al. (2007). Surface-enhanced Raman scattering immunoassays using a rotated capture substrate. Anal Chem 79: 4141-4148.
28. Dutta RK, Sharma PK, Pandey AC. (2009). Surface enhanced Raman spectra of Escherichia coli cells using ZnO nanoparticles. Dig J Nanomaterials Biostruct 4: 83-87.
29. Efrima S, Zeiri L. (2009). Understanding SERS of bacteria. J Raman Spectrosc 40: 277-288.
30. Fabris L, Dante M, Braun G, et al. (2007). A heterogeneous PNA-based SERS method for DNA detection. J Am Chem Soc 129: 6086-6087.
31. Fang C, Agarwal A, Buddharaju KD, et al. (2008). DNA detection using nanostructured SERS substrates with Rhodamine B as Raman label. Biosens Bioelectron 24: 216-221.
32. Firkala T, Farkas A, Vajna B, et al. (2013). Investigation of drug distribution in tablets using surface enhanced Raman chemical imaging. J Pharma Biomed Anal 76: 145-151.
33. Fleischmann M, Hendra PJ, McQuillan AJ. (1974). Raman spectra of pyridine adsorbed at a silver electrode. Chem Phys Lett 26: 163-166.
34. Freeman RD, Hammaker RM, Meloan CE, et al. (1988). A magnetic sample holder for Raman spectrometry. Appl Spectrosc 42: 1319-1321.
35. Fu S-Y, Zhang P-X. (1992). Chemical effect of chloride ions on SERS in silver sol. J Raman Spectrosc 23: 93-97.
36. Gopinath A, Boriskina SV, Premasiri WR, et al. (2009). Plasmonic nanogalaxies: Multiscale aperiodic arrays for surface-enhanced Raman sensing. Nano Lett 9: 3922-3929.
37. Gregas MK, Yan F, Scaffidi J, et al. (2011). Characterization of nanoprobe uptake in single cells: Spatial and temporal tracking via SERS labeling and modulation of surface charge. Nanomed Nanotechnol Biol Med 7: 115-122.
38. Grubisha DS, Lipert RJ, Park H-Y, et al. (2003). Femtomolar detection of prostate-specific antigen: An immunoassay based on surfaceenhanced Raman scattering and immunogold labels. Anal Chem 75: 5936-5943.
39. Guicheteau J, Christesen S, Emge D, et al. (2010). Bacterial mixture identification using Raman and surface-enhanced Raman chemical imaging. J Raman Spectrosc 41: 1632-1637.
40. Gupta S, Agrawal M, Conrad M, et al. (2010). Poly(2-(dimethylamino) ethyl methacrylate) brushes with incorporated nanoparticles as a SERS active sensing layer. Adv Funct Mater 20: 1756-1761.
41. Han XX, Xie Y, Zhao B, et al. (2010). Highly sensitive protein concentration assay over a wide range via surface-enhanced Raman scattering of coomassie brilliant blue. Anal Chem 82: 4325-4328.
42. Harpster MH, Zhang H, Sankara-Warrier AK, et al. (2009). SERS detection of indirect viral DNA capture using colloidal gold and methylene blue as a Raman label. Biosens Bioelectron 25: 674-681.
43. Hildebrandt P, Stockburger M. (1986). Surface enhanced resonance Raman study on fluorescein dyes. J Raman Spectrosc 17: 55-58.
44. Hobro AJ, Jabeen S, Chowdhry BZ, et al. (2010). Time dependence of SERS enhancement for pyrimidine nucleosides. J Phys Chem C 114: 7314-7323.
45. Huang P-J, Tay L-L, Tanha J, et al. (2009). Single-domain antibodyconjugated nanoaggregate-embedded beads for targeted detection of pathogenic bacteria. Chem Eur J 15: 9330-9334.
46. Izquierdo-Lorenzo I, García-Ramos JV, Sanchez-Cortes S. (2013). Vibrational characterization and surface-enhanced Raman scattering detection of probenecid doping drug. J Raman Spectrosc 44: 1422-1427.
47. Jarvis RM, Brooker A, Goodacre R. (2004). Surface-enhanced Raman spectroscopy for bacterial discrimination utilizing a scanning electron microscope with a Raman spectroscopy interface. Anal Chem 76: 5198-5202.
48. Jarvis RM, Goodacre R. (2008). Characterisation and identification of bacteria using SERS. Chem Soc Rev 37: 931-936.
49. Jeanmaire DL, Van Duyne RP. (1977). Surface raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode. J Electroanal Chem Interfacial Electrochem 84: 1-20.
50. Johannessen C, White PC, Abdali S. (2007). Resonance Raman optical activity and surface enhanced resonance Raman optical activity analysis of cytochrome c. J Phys Chem A 111: 7771-7776.
51. Jun BH, Noh MS, Kim J, et al. (2010). Multifunctional silver-embedded magnetic nanoparticles as SERS nanoprobes and their applications. Small 6: 119-125.
52. Kahraman M, Zamaleeva A, Fakhrullin R, et al. (2009). Layerby- layer coating of bacteria with noble metal nanoparticles for surface-enhanced Raman scattering. Anal Bioanal Chem 395: 2559-2567.
53. Kang B, Afifi MM, Austin LA, et al. (2013). Exploiting the nanoparticle plasmon effect: Observing drug delivery dynamics in single cells via Raman/fluorescence imaging spectroscopy. ACS Nano 7: 7420-7427.
54. Kang T, Yoo SM, Yoon I, et al. (2010). Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor. Nano Lett 10: 1189-1193.
55. Kasili P, Wabuyele M, Vo-Dinh T. (2006). Antibody-based SERS diagnostics of fhit protein without label. NanoBioTechnol 2: 29-35.
56. Keren S, Zavaleta C, Cheng Z, et al. (2008). Noninvasive molecular imaging of small living subjects using Raman spectroscopy. PNAS 105: 5844-5849.
57. Kneipp K, Kneipp H, Kartha VB, et al. (1998). Detection and identification of a single DNA base molecule using surface-enhanced Raman scattering (SERS). Phys Rev E 57:R6281-R6284.
58. Kneipp K, Wang Y, Kneipp H, et al. (1997). Single molecule detection using surface-enhanced Raman scattering (SERS). Phys Rev Lett 78: 1667-1670.
59. Kopito RR. (2000). Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10: 524-530.
60. Lanlan S, Yujing S, Fugang X, et al. (2009). Atomic force microscopy and surface-enhanced Raman scattering detection of DNA based on DNA-nanoparticle complexes. Nanotechnology 20: 125502-125514.
61. Le Ru EC, Etchegoin PG. (2009). Principles of surface-enhanced raman spectroscopy: and related plasmonic effects. Amsterdam; London, Elsevier Science.
62. Lee JW, Kim K, Shin KS. (2010). A novel fabrication of Au-coated glass capillaries for chemical analysis by surface-enhanced Raman scattering. Vibrat Spectrosc 53: 121-125.
63. Lee K, Irudayaraj J. (2009). Periodic and dynamic 3-D gold nanoparticleffl DNA network structures for surface-enhanced Raman spectroscopybased quantification. J Phys Chem C 113: 5980-5983.
64. Lee M, Lee S, Lee JH, et al. (2011). Highly reproducible immunoassay of cancer markers on a gold-patterned microarray chip using surfaceenhanced Raman scattering imaging. Biosens Bioelectron 26: 2135-2141.
65. Lee PC, Meisel D. (1982). Adsorption and surface-enhanced Raman of dyes on silver and gold sols. J Phys Chem 86: 3391-3395.
66. Lee S, Chon H, Lee M, et al. (2009). Surface-enhanced Raman scattering imaging of HER2 cancer markers overexpressed in single MCF7 cells using antibody conjugated hollow gold nanospheres. Biosens Bioelectron 24: 2260-2263.
67. Leopold N, Lendl B. (2003). A new method for fast preparation of highly surface-enhanced Raman scattering (SERS) active silver colloids at room temperature by reduction of silver nitrate with hydroxylamine hydrochloride. J Phys Chem B 107: 5723-5727.
68. Li W, Camargo PHC, Lu X, et al. (2008). Dimers of silver nanospheres: Facile synthesis and their use as hot spots for surface-enhanced Raman scattering. Nano Lett 9: 485-490.
69. Li Y-S, Cheng J, Coons LB. (1999). A silver solution for surfaceenhanced Raman scattering. Spectrochim Acta A: Mol Biomol Spectrosc 55: 1197-1207.
70. Lin H-H, Li Y-C, Chang C-H, et al. (2011). Single nuclei Raman spectroscopy for drug evaluation. Anal Chem 84: 113-120.
71. Ling X, Xie L, Fang Y, et al. (2009). Can graphene be used as a substrate for Raman enhancement? Nano Lett 10: 553-561.
72. Liu F, Cao Z, Tang C, et al. (2010). Ultrathin diamond-like carbon film coated silver nanoparticles-based substrates for surface-enhanced Raman spectroscopy. ACS Nano 4: 2643-2648.
73. Lombardi JR, Birke RL. (2009). A unified view of surface-enhanced Raman scattering. Acc Chem Res 42: 734-742.
74. Lowe AJ, Huh YS, Strickland AD, et al. (2010). Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction coupled surface enhanced Raman spectroscopy. Anal Chem 82: 5810-5814.
75. Maiti KK, Dinish US, Fu CY, et al. (2010). Development of biocompatible SERS nanotag with increased stability by chemisorption of reporter molecule for in vivo cancer detection. Biosens Bioelectron 26: 398-403.
76. Manno D, Filippo E, Fiore R, et al. (2010). Monitoring prion protein expression in complex biological samples by SERS for diagnostic applications. Nanotechnology 21: 165502-165508.
77. Margueritat Jr M, Gehan HLN, Grand J, et al. (2011). Influence of the number of nanoparticles on the enhancement properties of surface-enhanced Raman scattering active area: Sensitivity versus repeatability. ACS Nano 5: 1630-1638.
78. Moskovits M. (1978). Surface roughness and the enhanced intensity of Raman scattering by molecules adsorbed on metals. J Chem Phys 69: 4159-4161.
79. Muniz-Miranda M, Gellini C, Pagliai M, et al. (2010). SERS and computational studies on MicroRNA chains adsorbed on silver surfaces. J Phys Chem C 114: 13730-13735.
80. Munro CH, Smith WE, Armstrong DR, et al. (1995). Assignments and mechanism of SERRS of the hydrazone form for the azo dye solvent yellow 14. J Phys Chem 99: 879-885.
81. Naja G, Bouvrette P, Hrapovic S, et al. (2007). Raman-based detection of bacteria using silver nanoparticles conjugated with antibodies. Analyst 132: 679-686.
82. Neng J, Harpster MH, Zhang H, et al. (2010). A versatile SERS-based immunoassay for immunoglobulin detection using antigen-coated gold nanoparticles and malachite green-conjugated protein A/G. Biosens Bioelectron 26: 1009-1015.
83. Ni F, Sheng R, Cotton TM. (1990). Flow-injection analysis and real-time detection of RNA bases by surface-enhanced Raman spectroscopy. Anal Chem 62: 1958-1963.
84. Nicewarner-Pena SR, Freeman RG, Reiss BD, et al. (2001). Submicrometer metallic barcodes. Science 294: 137-141.
85. Nie S, Emory SR. (1997). Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science 275: 1102-1106.
86. Noh MS, Jun BH, Kim S, et al. (2009). Magnetic surface-enhanced Raman spectroscopic (M-SERS) dots for the identification of bronchioalveolar stem cells in normal and lung cancer mice. Biomaterials 30: 3915-3925.
87. Ock K, Jeon WI, Ganbold EO, et al. (2012). Real-time monitoring of glutathione-triggered thiopurine anticancer drug release in live cells investigated by surface-enhanced Raman scattering. Anal Chem 84: 2172-2178.
88. Oh Y-J, Park S-G, Kang M-H, et al. (2011). Beyond the SERS: Raman enhancement of small molecules using nanofluidic channels with localized surface plasmon resonance. Small 7: 184-188.
89. Osawa M. (2001). Surface-enhanced infrared absorption near-field optics and surface plasmon polaritons. In: Kawata S, ed. Topics in applied physics. Berlin/Heidelberg: Springer, 163-187.
90. Otto A, Timper J, Billmann J, et al. (1980). Surface roughness induced electronic Raman scattering. Surf Sci 92:L55-L57.
91. Parker WL, Hexter RM, Siedle AR. (1984). Raman spectroscopy as a probe of adsorption on rhodium particles. Chem Phys Lett 107: 96-98.
92. Patel IS, Premasiri WR, Moir DT, et al. (2008). Barcoding bacterial cells: A SERS-based methodology for pathogen identification. J Raman Spectrosc 39: 1660-1672.
93. Perry D, Boucher J, Posey K, et al. (2009a). Surface-enhanced spectroscopic investigation of the adsorption properties of hydroxybenzoic acid isomers onto metallic surfaces. Spectrochim Acta A Mol Biomol Spectrosc 74: 104-112.
94. Perry DA, Cordova JS, Smith LG, et al. (2009b). Study of adsorption of aminobenzoic acid isomers on silver nanostructures by surface-enhanced infrared spectroscopy. J Phys Chem C 113: 18304-18311.
95. Perry DA, Cordova JS, Smith LG, et al. (2011). Characterization of aminophenol isomer adsorption on silver nanostructures. Vibrat Spectrosc 55: 77-84.
96. Perry DA, Cordova JS, Spencer WD, et al. (2010a). SERS, SEIRA, TPD, and DFT study of cyanobenzoic acid isomer film growth on silver nanostructured films and powder. J Phys Chem C 114: 14953-14961.
97. Perry DA, Son HJ, Cordova JS, et al. (2010b). Adsorption analysis of nitrophenol isomers on silver nanostructures by surface-enhanced spectroscopy. J Colloid Interf Sci 342: 311-319.
98. Pockrand I. (1984). Surface enhanced Raman vibrational studies at solid/ gas interfaces. Berlin, New York: Springer-Verlag.
99. Posey KL, Viegas MG, Boucher AJ, et al. (2007). Surface-enhanced vibrational and TPD study of nitroaniline isomers. J Phys Chem C 111: 12352-12360.
100. Premasiri WR, Moir DT, Klempner MS, et al. (2004). Characterization of the Surface Enhanced Raman Scattering (SERS) of bacteria. J Phys Chem B 109: 312-320.
101. Rycenga M, Hou KK, Cobley CM, et al. (2009). Probing the surfaceenhanced Raman scattering properties of Au-Ag nanocages at two different excitation wavelengths. Phys Chem Chem Phys 11: 5903-5908.
102. Saar BG, Contreras-Rojas LR, Xie XS, et al. (2011). Imaging drug delivery to skin with stimulated Raman scattering microscopy. Mol Pharmaceutics 8: 969-975.
103. Schoch RB, Han J, Renaud P. (2008). Transport phenomena in nanofluidics. Rev Mod Phys 80: 839-883.
104. Sengupta A, Mujacic M, Davis E. (2006). Detection of bacteria by surface-enhanced Raman spectroscopy. Anal Bioanal Chem 386: 1379-1386.
105. Sha M, Penn S, Freeman G, et al. (2007). Detection of human viral RNA via a combined fluorescence and SERS molecular beacon assay. NanoBioTechnology 3: 23-30.
106. Sheng RS, Zhu L, Morris MD. (1986). Sedimentation classification of silver colloids for surface-enhanced Raman scattering. Anal Chem 58: 1116-1119.
107. Siiman O, Feilchenfeld H. (1988). Internal fractal structure of aggregates of silver particles and its consequences on surface-enhanced Raman scattering intensities. J Phys Chem 92: 453-464.
108. Smith M, Stambaugh K, Smith L, et al. (2009). Surface-enhanced vibrational investigation of adsorbed analgesics. Vibrat Spectrosc 49: 288-297.
109. Smith-Palmer T, Douglas C, Fredericks P. (2010). Rationalizing the SER spectra of bacteria. Vibrat Spectrosc 53: 103-106.
110. Song J, Zhou J, Duan H. (2012). Self-assembled plasmonic vesicles of SERS-encoded amphiphilic gold nanoparticles for cancer cell targeting and traceable intracellular drug delivery. J Am Chem Soc 134: 13458-13469.
111. Souza GR, Christianson DR, Staquicini FI, et al. (2006). Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proc Natl Acad Sci USA 103: 1215-1220.
112. Strelau KK, Kretschmer R, Moller R, et al. (2010). SERS as tool for the analysis of DNA-chips in a microfluidic platform. Anal Bioanal Chem 396: 1381-1384.
113. Sun J, Hankus ME, Cullum BM. (2009). SERS based immuno-microwell arrays for multiplexed detection of foodborne pathogenic bacteria. In: Brian MC, Marshall DP, eds. Smart biomedical and physiological sensor technology VI. SPIE, 73130K-73130K-73110.
114. Sun L, Irudayaraj J. (2009). Quantitative surface-enhanced Raman for gene expression estimation. Biophys J 96: 4709-4716.
115. Tarabara VV, Nabiev IR, Feofanov AV. (1998). Surface-Enhanced Raman Scattering (SERS) study of mercaptoethanol monolayer assemblies on silver citrate hydrosol. Preparation and characterization of modified hydrosol as a SERS-active substrate. Langmuir 14: 1092-1098.
116. Tian ZQ. (2005). Surface-enhanced Raman spectroscopy: Advancements and applications. J Raman Spectrosc 36: 466-470.
117. Torres EL, Winefordner JD. (1987). Trace determination of nitrogencontaining drugs by surface enhanced Raman scattering spectrometry on silver colloids. Anal Chem 59: 1626-1632.
118. Vitol EA, Brailoiu E, Orynbayeva Z, et al. (2010). Surface-enhanced Raman spectroscopy as a tool for detecting Ca2+ mobilizing second messengers in cell extracts. Anal Chem 82: 6770-6774.
119. Vogt FG, Strohmeier M. (2013). Confocal UV and resonance Raman microscopic imaging of pharmaceutical products. Mol Pharma 10: 4216-4228.
120. Wabuyele MB, Yan F, Vo-Dinh T. (2010). Plasmonics nanoprobes: Detection of single-nucleotide polymorphisms in the breast cancer BRCA1 gene. Anal Bioanal Chem 398: 729-736.
121. Wang H-N, Vo-Dinh T. (2009). Multiplex detection of breast cancer biomarkers using plasmonic molecular sentinel nanoprobes. Nanotechnology 20: 065101-065106.
122. Wu W, Hu M, Suong F, et al. (2010). Cones fabricated by 3D nanoimprint lithography for highly sensitive surface enhanced Raman spectroscopy. Nanotechnology 21: 255502-255507.
123. White I, Yazdi S, Yu W. (2012). Optofluidic SERS: Synergizing photonics and microfluidics for chemical and biological analysis. Microfluid Nanofluid 12: 205-216.
124. Wustholz KL, Brosseau CL, Casadio F, et al. (2009). Surface-enhanced Raman spectroscopy of dyes: From single molecules to the artists' canvas. Phys Chem Chem Phys 11: 7350-7359.
125. Xie L, Ling X, Fang Y, et al. (2009). Graphene as a substrate to suppress fluorescence in resonance Raman spectroscopy. J Am Chem Soc 131: 9890-9891.
126. Xu H, Aizpurua J, Kall M, et al. (2000). Electromagnetic contributions to single-molecule sensitivity in surface-enhanced raman scattering. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 62: 4318-4324.
127. Xu H, Bjerneld EJ, Kall M, et al. (1999). Spectroscopy of Single Hemoglobin Molecules by Surface Enhanced Raman Scattering. Phys Rev Lett 83: 4357-4360.
128. Xu Y, Zheng Y. (1989). Application of silver - surfactant colloid in surface-enchanced raman spectroscopy. Anal Chim Acta 225: 227-232.
129. Yan B, Reinhard BrM. (2010). Identification of tumor cells through spectroscopic profiling of the cellular surface chemistry. J Phys Chem Lett 1: 1595-1598.
130. Yu X, Cai H, Zhang W, et al. (2011). Tuning chemical enhancement of SERS by controlling the chemical reduction of graphene oxide nanosheets. ACS Nano 5: 952-958.
131. Yuan W, Ho HP, Lee RK, et al. (2009). Surface-enhanced Raman scattering biosensor for DNA detection on nanoparticle island substrates. Appl Optics 48: 4329-4337.
132. Yuen C, Zheng W, Huang Z. (2010). Low-level detection of anti-cancer drug in blood plasma using microwave-treated gold-polystyrene beads as surface-enhanced Raman scattering substrates. Biosens Bioelectron 26: 580-584.
133. Zavaleta CL, Smith BR, Walton I, et al. (2009). Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy. PNAS 106: 13511-13516.
134. Zong S, Wang Z, Chen H, et al. (2013). Surface enhanced Raman scattering traceable and glutathione responsive nanocarrier for the intracellular drug delivery. Anal Chem 85: 2223-2230.