메뉴 건너뛰기




Volumn 33, Issue 16, 2014, Pages 2040-2052

Phosphorylation of Nanog is essential to regulate Bmi1 and promote tumorigenesis

Author keywords

cancer stem cells; cancer initiating cells; Head and neck cancer; p300; protein kinase C

Indexed keywords

ANIMALS; BASE SEQUENCE; BINDING SITES; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; MASS SPECTROMETRY; MICE; MICE, NUDE; MUTATION; PHOSPHORYLATION; POLYCOMB REPRESSIVE COMPLEX 1; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C-EPSILON; THREONINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84899443873     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.173     Document Type: Article
Times cited : (38)

References (45)
  • 1
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 2000; 24: 372-376
    • (2000) Nat Genet , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 2
    • 0037806031 scopus 로고    scopus 로고
    • The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
    • Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 2003; 113: 631-642
    • (2003) Cell , vol.113 , pp. 631-642
    • Mitsui, K.1    Tokuzawa, Y.2    Itoh, H.3    Segawa, K.4    Murakami, M.5    Takahashi, K.6
  • 3
    • 34249876564 scopus 로고    scopus 로고
    • Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    • Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, et al. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nat Cell Biol 2007; 9: 625-635
    • (2007) Nat Cell Biol , vol.9 , pp. 625-635
    • Masui, S.1    Nakatake, Y.2    Toyooka, Y.3    Shimosato, D.4    Yagi, R.5    Takahashi, K.6
  • 4
    • 38849204756 scopus 로고    scopus 로고
    • Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3
    • Torres J, Watt FM. Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3. Nat Cell Biol 2008; 10: 194-201
    • (2008) Nat Cell Biol , vol.10 , pp. 194-201
    • Torres, J.1    Watt, F.M.2
  • 5
    • 77950560406 scopus 로고    scopus 로고
    • Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression
    • Zhang P, Andrianakos R, Yang Y, Liu C, Lu W. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. J Biol Chem 2010; 285: 9180-9189
    • (2010) J Biol Chem , vol.285 , pp. 9180-9189
    • Zhang, P.1    Andrianakos, R.2    Yang, Y.3    Liu, C.4    Lu, W.5
  • 6
    • 79952283423 scopus 로고    scopus 로고
    • MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation
    • Yu CC, Chen YW, Chiou GY, Tsai LL, Huang PI, Chang CY, et al. MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation. Oral Oncol 2011; 47: 202-210
    • (2011) Oral Oncol , vol.47 , pp. 202-210
    • Yu, C.C.1    Chen, Y.W.2    Chiou, G.Y.3    Tsai, L.L.4    Huang, P.I.5    Chang, C.Y.6
  • 7
    • 48249105531 scopus 로고    scopus 로고
    • Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma
    • Chiou SH, Yu CC, Huang CY, Lin SC, Liu CJ, Tsai TH, et al. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res 2008; 14: 4085-4095
    • (2008) Clin Cancer Res , vol.14 , pp. 4085-4095
    • Chiou, S.H.1    Yu, C.C.2    Huang, C.Y.3    Lin, S.C.4    Liu, C.J.5    Tsai, T.H.6
  • 8
    • 84862816188 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of NANOG reduces cell proliferation and induces G0/G1 cell cycle arrest in breast cancer cells
    • Han J, Zhang F, Yu M, Zhao P, Ji W, Zhang H, et al. RNA interference-mediated silencing of NANOG reduces cell proliferation and induces G0/G1 cell cycle arrest in breast cancer cells. Cancer Lett 2012; 321: 80-88
    • (2012) Cancer Lett , vol.321 , pp. 80-88
    • Han, J.1    Zhang, F.2    Yu, M.3    Zhao, P.4    Ji, W.5    Zhang, H.6
  • 9
    • 78650389774 scopus 로고    scopus 로고
    • Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation
    • Chiou SH, Wang ML, Chou YT, Chen CJ, Hong CF, Hsieh WJ, et al. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res 2010; 70: 10433-10444
    • (2010) Cancer Res , vol.70 , pp. 10433-10444
    • Chiou, S.H.1    Wang, M.L.2    Chou, Y.T.3    Chen, C.J.4    Hong, C.F.5    Hsieh, W.J.6
  • 10
    • 77953553879 scopus 로고    scopus 로고
    • Overexpression of nanog predicts tumor progression and poor prognosis in colorectal cancer
    • Meng HM, Zheng P, Wang XY, Liu C, Sui HM, Wu SJ, et al. Overexpression of nanog predicts tumor progression and poor prognosis in colorectal cancer. Cancer Biol Ther 2010; 9: 295-302
    • (2010) Cancer Biol Ther , vol.9 , pp. 295-302
    • Meng, H.M.1    Zheng, P.2    Wang, X.Y.3    Liu, C.4    Sui, H.M.5    Wu, S.J.6
  • 11
    • 66149167315 scopus 로고    scopus 로고
    • Functional evidence that the self-renewal gene NANOG regulates human tumor development
    • Jeter CR, Badeaux M, Choy G, Chandra D, Patrawala L, Liu C, et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells 2009; 27: 993-1005
    • (2009) Stem Cells , vol.27 , pp. 993-1005
    • Jeter, C.R.1    Badeaux, M.2    Choy, G.3    Chandra, D.4    Patrawala, L.5    Liu, C.6
  • 12
    • 77955428416 scopus 로고    scopus 로고
    • NANOG regulates glioma stem cells and is essential in vivo acting in a crossfunctional network with GLI1 and p53
    • Zbinden M, Duquet A, Lorente-Trigos A, Ngwabyt SN, Borges I, Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a crossfunctional network with GLI1 and p53. EMBO J 2010; 29: 2659-2674
    • (2010) EMBO J , vol.29 , pp. 2659-2674
    • Zbinden, M.1    Duquet, A.2    Lorente-Trigos, A.3    Ngwabyt, S.N.4    Borges, I.5    Ruiz, I.6    Altaba, A.7
  • 13
    • 79960805359 scopus 로고    scopus 로고
    • Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma
    • Tsai LL, Yu CC, Chang YC, Yu CH, Chou MY. Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma. J Oral Pathol Med 2011; 40: 621-628
    • (2011) J Oral Pathol Med , vol.40 , pp. 621-628
    • Tsai, L.L.1    Yu, C.C.2    Chang, Y.C.3    Yu, C.H.4    Chou, M.Y.5
  • 15
    • 84855781227 scopus 로고    scopus 로고
    • Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-Activated head and neck squamous cell carcinoma cells
    • Bourguignon LY, Earle C, Wong G, Spevak CC, Krueger K. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-Activated head and neck squamous cell carcinoma cells. Oncogene 2012; 31: 149-160
    • (2012) Oncogene , vol.31 , pp. 149-160
    • Bourguignon, L.Y.1    Earle, C.2    Wong, G.3    Spevak, C.C.4    Krueger, K.5
  • 16
    • 70350362953 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-Apoptosis, and chemotherapy resistance in breast tumor cells
    • Bourguignon LY, Spevak CC, Wong G, Xia W, Gilad E. Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-Apoptosis, and chemotherapy resistance in breast tumor cells. J Biol Chem 2009; 284: 26533-26546
    • (2009) J Biol Chem , vol.284 , pp. 26533-26546
    • Bourguignon, L.Y.1    Spevak, C.C.2    Wong, G.3    Xia, W.4    Gilad, E.5
  • 19
    • 84861535841 scopus 로고    scopus 로고
    • Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated
    • Ho B, Olson G, Figel S, Gelman I, Cance WG, Golubovskaya VM. Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem 2012; 287: 18656-18673
    • (2012) J Biol Chem , vol.287 , pp. 18656-18673
    • Ho, B.1    Olson, G.2    Figel, S.3    Gelman, I.4    Cance, W.G.5    Golubovskaya, V.M.6
  • 21
    • 44049088472 scopus 로고    scopus 로고
    • Requirement of Nanog dimerization for stem cell self-renewal and pluripotency
    • Wang J, Levasseur DN, Orkin SH. Requirement of Nanog dimerization for stem cell self-renewal and pluripotency. Proc Natl Acad Sci USA 2008; 105: 6326-6331
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6326-6331
    • Wang, J.1    Levasseur, D.N.2    Orkin, S.H.3
  • 22
    • 12544257052 scopus 로고    scopus 로고
    • The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus
    • Pan G, Pei D. The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus. J Biol Chem 2005; 280: 1401-1407
    • (2005) J Biol Chem , vol.280 , pp. 1401-1407
    • Pan, G.1    Pei, D.2
  • 23
    • 66149149780 scopus 로고    scopus 로고
    • Two potent transactivation domains in the C-Terminal region of human NANOG mediate transcriptional activation in human embryonic carcinoma cells
    • Do HJ, Lee WY, Lim HY, Oh JH, Kim DK, Kim JH, et al. Two potent transactivation domains in the C-Terminal region of human NANOG mediate transcriptional activation in human embryonic carcinoma cells. J Cell Biochem 2009; 106: 1079-1089
    • (2009) J Cell Biochem , vol.106 , pp. 1079-1089
    • Do, H.J.1    Lee, W.Y.2    Lim, H.Y.3    Oh, J.H.4    Kim, D.K.5    Kim, J.H.6
  • 24
    • 33750379275 scopus 로고    scopus 로고
    • Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma
    • Pan Q, Bao LW, Teknos TN, Merajver SD. Targeted disruption of protein kinase C epsilon reduces cell invasion and motility through inactivation of RhoA and RhoC GTPases in head and neck squamous cell carcinoma. Cancer Res 2006; 66: 9379-9384
    • (2006) Cancer Res , vol.66 , pp. 9379-9384
    • Pan, Q.1    Bao, L.W.2    Teknos, T.N.3    Merajver, S.D.4
  • 25
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008; 133: 1106-1117
    • (2008) Cell , vol.133 , pp. 1106-1117
    • Chen, X.1    Xu, H.2    Yuan, P.3    Fang, F.4    Huss, M.5    Vega, V.B.6
  • 26
    • 82755162926 scopus 로고    scopus 로고
    • Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells
    • Das S, Jena S, Levasseur DN. Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells. J Biol Chem 2011; 286: 42690-42703
    • (2011) J Biol Chem , vol.286 , pp. 42690-42703
    • Das, S.1    Jena, S.2    Levasseur, D.N.3
  • 28
    • 33745685884 scopus 로고    scopus 로고
    • Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells
    • Song LB, Zeng MS, Liao WT, Zhang L, Mo HY, Liu WL, et al. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res 2006; 66: 6225-6232
    • (2006) Cancer Res , vol.66 , pp. 6225-6232
    • Song, L.B.1    Zeng, M.S.2    Liao, W.T.3    Zhang, L.4    Mo, H.Y.5    Liu, W.L.6
  • 30
    • 59649121301 scopus 로고    scopus 로고
    • Co-expression of Bmi-1 and podoplanin predicts overall survival in patients with squamous cell carcinoma of the head and neck treated with radio (chemo)therapy
    • Vormittag L, Thurnher D, Geleff S, Pammer J, Heiduschka G, Brunner M, et al. Co-expression of Bmi-1 and podoplanin predicts overall survival in patients with squamous cell carcinoma of the head and neck treated with radio (chemo)therapy. Int J Radiat Oncol Biol Phys 2009; 73: 913-918
    • (2009) Int J Radiat Oncol Biol Phys , vol.73 , pp. 913-918
    • Vormittag, L.1    Thurnher, D.2    Geleff, S.3    Pammer, J.4    Heiduschka, G.5    Brunner, M.6
  • 31
    • 77649274663 scopus 로고    scopus 로고
    • Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue
    • Hayry V, Makinen LK, Atula T, Sariola H, Makitie A, Leivo I, et al. Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue. Br J Cancer 2010; 102: 892-897
    • (2010) Br J Cancer , vol.102 , pp. 892-897
    • Hayry, V.1    Makinen, L.K.2    Atula, T.3    Sariola, H.4    Makitie, A.5    Leivo, I.6
  • 32
    • 76149111625 scopus 로고    scopus 로고
    • Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factorkappaB Pathway
    • Li J, Gong LY, Song LB, Jiang LL, Liu LP, Wu J, et al. Oncoprotein Bmi-1 renders apoptotic resistance to glioma cells through activation of the IKK-nuclear factorkappaB Pathway. Am J Pathol 2010; 176: 699-709
    • (2010) Am J Pathol , vol.176 , pp. 699-709
    • Li, J.1    Gong, L.Y.2    Song, L.B.3    Jiang, L.L.4    Liu, L.P.5    Wu, J.6
  • 33
    • 20444457518 scopus 로고    scopus 로고
    • Microarray analysis identifies a death-fromcancer signature predicting therapy failure in patients with multiple types of cancer
    • Glinsky GV, Berezovska O, Glinskii AB. Microarray analysis identifies a death-fromcancer signature predicting therapy failure in patients with multiple types of cancer. J Clin Invest 2005; 115: 1503-1521
    • (2005) J Clin Invest , vol.115 , pp. 1503-1521
    • Glinsky, G.V.1    Berezovska, O.2    Glinskii, A.B.3
  • 34
    • 1642633053 scopus 로고    scopus 로고
    • Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas
    • Leung C, Lingbeek M, Shakhova O, Liu J, Tanger E, Saremaslani P, et al. Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas. Nature 2004; 428: 337-341
    • (2004) Nature , vol.428 , pp. 337-341
    • Leung, C.1    Lingbeek, M.2    Shakhova, O.3    Liu, J.4    Tanger, E.5    Saremaslani, P.6
  • 35
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci USA 2007; 104: 973-978
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 973-978
    • Prince, M.E.1    Sivanandan, R.2    Kaczorowski, A.3    Wolf, G.T.4    Kaplan, M.J.5    Dalerba, P.6
  • 36
    • 54249132606 scopus 로고    scopus 로고
    • The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma
    • Chiba T, Miyagi S, Saraya A, Aoki R, Seki A, Morita Y, et al. The polycomb gene product BMI1 contributes to the maintenance of tumor-initiating side population cells in hepatocellular carcinoma. Cancer Res 2008; 68: 7742-7749
    • (2008) Cancer Res , vol.68 , pp. 7742-7749
    • Chiba, T.1    Miyagi, S.2    Saraya, A.3    Aoki, R.4    Seki, A.5    Morita, Y.6
  • 37
    • 78649669021 scopus 로고    scopus 로고
    • Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation
    • Lukacs RU, Memarzadeh S, Wu H, Witte ON. Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell Stem Cell 2010; 7: 682-693
    • (2010) Cell Stem Cell , vol.7 , pp. 682-693
    • Lukacs, R.U.1    Memarzadeh, S.2    Wu, H.3    Witte, O.N.4
  • 40
    • 84863660020 scopus 로고    scopus 로고
    • Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development
    • Lavial F, Bessonnard S, Ohnishi Y, Tsumura A, Chandrashekran A, Fenwick MA, et al. Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Genes Dev 2012; 26: 1445-1458
    • (2012) Genes Dev , vol.26 , pp. 1445-1458
    • Lavial, F.1    Bessonnard, S.2    Ohnishi, Y.3    Tsumura, A.4    Chandrashekran, A.5    Fenwick, M.A.6
  • 41
    • 84874627380 scopus 로고    scopus 로고
    • The CD133' subpopulation of the SW982 human synovial sarcoma cell line exhibits cancer stem-like characteristics
    • Liu A, Feng B, Gu W, Cheng X, Tong T, Zhang H, et al. The CD133' subpopulation of the SW982 human synovial sarcoma cell line exhibits cancer stem-like characteristics. Int J Oncol 2013; 42: 1399-1407
    • (2013) Int J Oncol , vol.42 , pp. 1399-1407
    • Liu, A.1    Feng, B.2    Gu, W.3    Cheng, X.4    Tong, T.5    Zhang, H.6
  • 42
    • 84862824245 scopus 로고    scopus 로고
    • Cancer stem-like cells contribute to cisplatin resistance and progression in bladder cancer
    • Zhang Y, Wang Z, Yu J, Shi J, Wang C, Fu W, et al. Cancer stem-like cells contribute to cisplatin resistance and progression in bladder cancer. Cancer Lett 2012; 322: 70-77
    • (2012) Cancer Lett , vol.322 , pp. 70-77
    • Zhang, Y.1    Wang, Z.2    Yu, J.3    Shi, J.4    Wang, C.5    Fu, W.6
  • 43
    • 80053257189 scopus 로고    scopus 로고
    • CD133' cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Mullerian tumor
    • Choijamts B, Jimi S, Kondo T, Naganuma Y, Matsumoto T, Kuroki M, et al. CD133' cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Mullerian tumor). Stem Cells 2011; 29: 1485-1495
    • (2011) Stem Cells , vol.29 , pp. 1485-1495
    • Choijamts, B.1    Jimi, S.2    Kondo, T.3    Naganuma, Y.4    Matsumoto, T.5    Kuroki, M.6
  • 44
    • 31344449923 scopus 로고    scopus 로고
    • A general precursor ion-like scanning mode on quadrupole-TOF instruments compatible with chromatographic separation
    • Niggeweg R, Kocher T, Gentzel M, Buscaino A, Taipale M, Akhtar A, et al. A general precursor ion-like scanning mode on quadrupole-TOF instruments compatible with chromatographic separation. Proteomics 2006; 6: 41-53
    • (2006) Proteomics , vol.6 , pp. 41-53
    • Niggeweg, R.1    Kocher, T.2    Gentzel, M.3    Buscaino, A.4    Taipale, M.5    Akhtar, A.6
  • 45
    • 0035298820 scopus 로고    scopus 로고
    • Detection of tyrosine phosphorylated peptides by precursor ion scanning quadrupole TOF mass spectrometry in positive ion mode
    • Steen H, Kuster B, Fernandez M, Pandey A, Mann M. Detection of tyrosine phosphorylated peptides by precursor ion scanning quadrupole TOF mass spectrometry in positive ion mode. Anal Chem 2001; 73: 1440-1448
    • (2001) Anal Chem , vol.73 , pp. 1440-1448
    • Steen, H.1    Kuster, B.2    Fernandez, M.3    Pandey, A.4    Mann, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.