Effect of ambrex (a herbal formulation) on oxidative stress in hyperlipidemic rats and differentiation of 3T3-L1 preadipocytes

Pharmacognosy Magazine

Volumn 10, Issue 38, 2014, Pages 165-171

  Devi, A Jamuna ^a   Ravindran, Rekha ^a   Sankar, M ^a   Rajkumar, Johanna ^a  

^a RAJALAKSHMI ENGINEERING COLLEGE   (India)

Author keywords

3T3 L1 cell line; antioxidants; oxidative stress; peroxisome proliferator activated receptor gamma; sterol regulatory binding proteins

Indexed keywords

AMBREX; ANTIOXIDANT; ATORVASTATIN; CATALASE; CHOLESTEROL; GLUTATHIONE; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; LEPTIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN; SUPEROXIDE DISMUTASE; THIOREDOXIN 1; THIOREDOXIN 2; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AMBER; ANTILIPEMIC AGENT; MALONALDEHYDE;

3T3 CELL LINE; ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DIFFERENTIATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYCAS; CYCAS CIRCIRNALIS; DRUG EFFECT; GENE EXPRESSION; HYPERLIPIDEMIA; IN VITRO STUDY; INFLAMMATION; LIPID DIET; MALE; MEDICINAL PLANT; NONHUMAN; ORCHIS; ORCHIS MASCULA; OXIDATIVE STRESS; PROADIPOCYTE; PROTEIN EXPRESSION; RAT; SHOREA ROBUSTA; UPREGULATION; WITHANIA SOMNIFERA; ANIMAL CELL; ANIMAL TISSUE; DRUG MECHANISM; ENZYME ACTIVITY; HEART; LIVER; SERUM; TRIACYLGLYCEROL BLOOD LEVEL; WISTAR RAT;

EID: 84899431637     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.131030     Document Type: Article

References (33)

1. Mataix J, Quiles JL, Huertas JR, Battino M, Mañas M. Tissue specific interactions of exercise, dietary fatty acids, and vitamin E in lipid peroxidation. Free Radic Biol Med 1998;24:511-21.
2. Wassmann S, Wassmann K, Nickenig G. Modulation of oxidant and antioxidant enzyme expression and function in vascular cells. Hypertension 2004;44:381-6.
3. Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piché LA, et al. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100.
4. Roberfoid M, Calderon PB. Free Radicals and Oxidation Phenomena in Biological Systems. Belgium: University Catholique de Lourian Bussels; 1995.
5. Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol 2003;91:7A-11.
6. Ochani PC, D'Mello P. Antioxidant and antihyperlipidemic activity of Hibiscus sabdariffa Linn. leaves and calyces extracts in rats. Indian J Exp Biol 2009;47:276-82.
7. Yazdanparast R, Bahramikia S, Ardestani A. Nasturtium officinale reduces oxidative stress and enhances antioxidant capacity in hypercholesterolaemic rats. Chem Biol Interact 2008;172:176-84.
8. Küskü-Kiraz Z, Mehmetçik G, Dogru-Abbasoglu S, Uysal M. Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet. Phytother Res 2010;24:565-70.
9. Küçükgergin C, Aydin AF, Ozdemirler-Erata G, Mehmetçik G, Koçak-Toker N, Uysal M. Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet. Biol Trace Elem Res 2010;135:264-74.
10. Vidal-Puig A, Jimenez-Liñan M, Lowell BB, Hamann A, Hu E, Spiegelman B, et al. Regulation of PPAR gamma gene expression by nutrition and obesity in rodents. J Clin Invest 1996;97:2553-61.
11. Vidal-Puig AJ, Considine RV, Jimenez-Liñan M, Werman A, Pories WJ, Caro JF, et al. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 1997;99:2416-22.
12. Devi RS, Narayan S, Mohan KV, Sabitha KE, Devi CS. Effect of a polyherbal formulation, Ambrex, on butylated hydroxy toluene (BHT) induced toxicity in rats. Indian J Exp Biol 2003;41:1294-9.
13. Jainu M, Devi CS. Effect of ambrex (an amber based formulation) on gastric mucosal damage: Role of antioxidant enzymes and lipid profile. Indian J Physiol Pharmacol 2004;48:343-7.
14. Zhao H, Wang Y, Wu Y, Li X, Yang G, Ma X, et al. Hyperlipidemia does not prevent the cardioprotection by postconditioning against myocardial ischemia/reperfusion injury and the involvement of hypoxia inducible factor-1alpha upregulation. Acta Biochim Biophys Sin (Shanghai) 2009;41:745-53.
15. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 1978;86:271-8.
16. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963;61:882-8.
17. Ellman GL. Tissue sulfahydral groups. Arch Biochem Biophys 1959;82:70-7.
18. Nishikimi M, Appaji N, Yagi K the occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun 1972;46:849-54.
19. Aebi H. Catalase in vitro. Methods Enzymol 1984;105:121-6.
20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
22. Yilmaz MI, Baykal Y, Kilic M, Sonmez A, Bulucu F, Aydin A, et al. Effects of statins on oxidative stress. Biol Trace Elem Res 2004;98:119-27.
23. De Caterina R, Cipollone F, Filardo FP, Zimarino M, Bernini W, Lazzerini G, et al. Low-density lipoprotein level reduction by the 3-hydroxy-3- methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: No further effect of vitamin E. Circulation 2002;106:2543-9.
24. Cooper AJ, Kristal BS. Multiple roles of glutathione in the central nervous system. Biol Chem 1997;378:793-802.
25. Anila L, Vijayalakshmi NR. Antioxidant action of flavonoids from Mangifera indica and Emblica officinalis in hypercholesterolemic rats. Food Chem 2003;83:569-574.
26. Fki I, Bouaziz M, Sahnoun Z, Sayadi S. Hypercholesterolemic effects of phenolic rich extracts of Chemlali olive cultivar in rats fed a cholesterol-rich diet. Bioorg Med Chem 1997;378:793-802.
27. Yalçin AS, Sabuncu N, Kilinç A, Gülcan G, Emerk K. Increased plasma and erythrocyte lipid peroxidation in hyperlipidemic individuals. Atherosclerosis 1989;80:169-70.
28. Kumar SA, Sudhahar V, Varalakshmi P. Attenuation of serum lipid abnormalities and cardiac oxidative stress by eicosapentaenoate-lipoate (EPA-LA) derivative in experimental hypercholesterolemia. Clin Chim Acta 2005;355:197-204.
29. Archana R, Namasivayam A. Antistressor effect of Withania somnifera. J Ethnopharmacol 1999;64:91-3.
30. Park CH, Yamabe N, Noh JS, Kang KS, Tanaka T, Yokozawa T the beneficial effects of morroniside on the inflammatory response and lipid metabolism in the liver of db/db mice. Biol Pharm Bull 2009;32:1734-40.
31. Raclot T, Groscolas R, Langin D, Ferré P. Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. J Lipid Res 1997;38:1963-72.
32. Stumvoll M, Fritsche A, Tschritter O, Lehmann R, Wahl HG, Renn W, et al. Leptin levels in humans are acutely suppressed by isoproterenol despite acipimox-induced inhibition of lipolysis, but not by free fatty acids. Metabolism 2000;49:335-9.
33. Ravindran R, Devi J, Rajkumar J. In vitro antioxidant activity of an ancient amber based herbal formulation "Ambrex". Int J Mod Sci Eng 2012;1:1-9.