Mycobacterium bovis BCG triggered MyD88 induces miR-124 feedback negatively regulates immune response in alveolar epithelial cells

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Ma, Chunyan ^a,b   Li, Yong ^a,b   Zeng, Jin ^a,b   Wu, Xiaoling ^a,b   Liu, Xiaoming ^a,b   Wang, Yujiong ^a,b  

^a Key Lab of the Min of Educ for Conserv and Utiliz of Spec Biol Resources in Western China   (China)

^b NINGXIA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; BETA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12P35; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; INTERLEUKIN 8; MICRORNA 124; MYELOID DIFFERENTIATION FACTOR 88; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; MICRORNA; MIRN124 MICRORNA, MOUSE; MYD88 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOVINE TUBERCULOSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME REGULATION; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; INFECTION PREVENTION; INFLAMMATION; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG TUBERCULOSIS; MOUSE; MYCOBACTERIUM BOVIS BCG; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; ADAPTIVE IMMUNITY; ANIMAL; C57BL MOUSE; CELL CULTURE; EPITHELIUM CELL; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LUNG ALVEOLUS; METABOLISM; MICROBIOLOGY; MYCOBACTERIOSIS; MYCOBACTERIUM BOVIS; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA;

ADAPTIVE IMMUNITY; ANIMALS; CELLS, CULTURED; EPITHELIAL CELLS; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, INBRED C57BL; MICRORNAS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM INFECTIONS; MYELOID DIFFERENTIATION FACTOR 88; PULMONARY ALVEOLI; RESPIRATORY MUCOSA;

EID: 84899413571     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092419     Document Type: Article

References (46)

1. WHO (2013) WHO report. Global tuberculosis control: surveillance, planning, financing, Geneva: WHO pp: 1-306.
2. Kaufmann SH, Cole ST, Mizrahi V, Rubin E, Nathan C (2005) Mycobacterium tuberculosis and the host response. J Exp Med 201: 1693-1697. (Pubitemid 41002887)
3. Méndez-Samperio P, Belmont L, Miranda E (2008) Mycobacterium bovis BCG Toll-Like Receptors 2 and 4 Cooperation Increases the Innate Epithelial Immune Response. Archives of medical research 39: 33-39. (Pubitemid 350192009)
4. Guilliams M, Lambrecht BN, Hammad H (2013) Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections. Mucosal Immunol 6: 464-473.
5. Poirier V, Av-Gay Y (2012) Mycobacterium tuberculosis modulators of the macrophage's cellular events. Microbes Infect 14: 1211-1219.
6. McDonough KA, Kress Y (1995) Cytotoxicity for lung epithelial cells is a virulence-associated phenotype of Mycobacterium tuberculosis. Infect Immun 63: 4802-4811.
7. Bermudez LE, Goodman J (1996) Mycobacterium tuberculosis invades and replicates within type II alveolar cells. Infect Immun 64: 1400-1406. (Pubitemid 26102407)
8. Li Y, Wang Y, Liu X (2012) The role of airway epithelial cells in response to mycobacteria infection. Clin Dev Immunol 2012: 791392.
9. Lin Y, Zhang M, Barnes PF (1998) Chemokine production by a human alveolar epithelial cell line in response to Mycobacterium tuberculosis. Infect Immun 66: 1121-1126. (Pubitemid 28101155)
10. Mayer AK, Dalpke AH (2007) Regulation of local immunity by airway epithelial cells. Archivum immunologiae et therapiae experimentalis 55: 353-362.
11. Diamond G, Legarda D, Ryan LK (2002) The innate immune response of the respiratory epithelium. Immunological reviews 173: 27-38.
12. Mendez-Samperio P, Trejo A, Perez A (2008) Mycobacterium bovis Bacillus Calmette-Guerin (BCG) stimulates IL-10 production via the PI3K/Akt and p38 MAPK pathways in human lung epithelial cells. Cell Immunol 251: 37-42.
13. Gereke M, Jung S, Buer J, Bruder D (2009) Alveolar type II epithelial cells present antigen to CD4(+) T cells and induce Foxp3(+) regulatory T cells. Am J Respir Crit Care Med 179: 344-355.
14. Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl K, Singh M, et al. (2012) The role of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune systems. PLoS One 7: e32125.
15. Bartel DP (2004) MicroRNAs: Genomics, Biogenesis, Mechanism, and Function. Cell 116: 281-297.
16. Zhu S, Pan W, Qian Y (2013) MicroRNA in immunity and autoimmunity. Journal of Molecular Medicine: 1-12.
17. O'Neill LA, Sheedy FJ, McCoy CE (2011) MicroRNAs: the fine-tuners of Toll-like receptor signalling. Nat Rev Immunol 11: 163-175.
18. Johnnidis JB, Harris MH, Wheeler RT, Stehling-Sun S, Lam MH, et al. (2008) Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature 451: 1125-1129. (Pubitemid 351317447)
19. Tili E, Michaille J-J, Cimino A, Costinean S, Dumitru CD, et al. (2007) Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF- α stimulation and their possible roles in regulating the response to endotoxin shock. The Journal of Immunology 179: 5082-5089.
20. Iliopoulos D, Hirsch HA, Struhl K (2009) An epigenetic switch involving NF-kB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139: 693-706.
21. Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, et al. (2009) Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nature immunology 11: 141-147.
22. Taganov KD, Boldin MP, Chang K-J, Baltimore D (2006) NF-kB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proceedings of the National Academy of Sciences 103: 12481-12486. (Pubitemid 44267285)
23. Ryul Lee M, Soo Kim J, Kim KS (2010) miR-124a Is Important for Migratory Cell Fate Transition During Gastrulation of Human Embryonic Stem Cells. Stem Cells 28: 1550-1559.
24. Cheng L-C, Pastrana E, Tavazoie M, Doetsch F (2009) miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche. Nature neuroscience 12: 399-408.
25. Xia H, Cheung WK, Ng SS, Jiang X, Jiang S, et al. (2012) Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells. Journal of Biological Chemistry 287: 9962-9971.
26. Zheng F, Liao Y-J, Cai M-Y, Liu Y-H, Liu T-H, et al. (2012) The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 61: 278-289.
27. Koukos G, Polytarchou C, Kaplan JL, Morley-Fletcher A, Gras-Miralles B, et al. (2013) MicroRNA-124 Regulates STAT3 Expression and is Downregulated in Colon Tissues of Pediatric Patients with Ulcerative Colitis. Gastroenterology 145: 142-152
28. Liang YJ, Wang QY, Zhou CX, Yin QQ, He M, et al. (2013) MiR-124 targets Slug to regulate epithelial-mesenchymal transition and metastasis of breast cancer. Carcinogenesis 34: 713-722.
29. Chen J, Xie F, Zhang L, Jiang WG (2010) iASPP is over-expressed in human non-small cell lung cancer and regulates the proliferation of lung cancer cells through a p53 associated pathway. BMC cancer 10: 694.
30. Liu K, Zhao H, Yao H, Lei S, Lei Z, et al. (2013) MicroRNA-124 regulates the proliferation of colorectal cancer cells by targeting iASPP. Biomed Res Int 2013: 867537.
31. Wei J, Wang F, Kong LY, Xu S, Doucette T, et al. (2013) miR-124 Inhibits STAT3 Signaling to Enhance T Cell-Mediated Immune Clearance of Glioma. Cancer Res 73: 3913-3926.
32. Quesniaux V, Fremond C, Jacobs M, Parida S, Nicolle D, et al. (2004) Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect 6: 946-959. (Pubitemid 39061217)
33. McCoy CE (2011) The role of miRNAs in cytokine signaling. Front Biosci (Landmark Ed) 16: 2161-2171.
34. Zheng F, Liao YJ, Cai MY, Liu YH, Liu TH, et al. (2012) The putative tumour suppressor microRNA-124 modulates hepatocellular carcinoma cell aggressiveness by repressing ROCK2 and EZH2. Gut 61: 278-289.
35. Takeda K, Akira S (2004) TLR signaling pathways, Philadelphia:WB Saunders pp. 3-10.
36. Koch M, Mollenkopf HJ, Klemm U, Meyer TF (2012) Induction of microRNA- 155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis. Proc Natl Acad Sci U S A 109: E1153-1162.
37. Nahid MA, Satoh M, Chan EK (2011) Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling. J Immunol 186: 1723-1734.
38. Wang P, Hou J, Lin L, Wang C, Liu X, et al. (2010) Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1. J Immunol 185: 6226-6233.
39. Ma X, Becker Buscaglia LE, Barker JR, Li Y (2011) MicroRNAs in NF-kappaB signaling. J Mol Cell Biol 3: 159-166.
40. O'Connell RM, Taganov KD, Boldin MP, Cheng G, Baltimore D (2007) MicroRNA-155 is induced during the macrophage inflammatory response. Proc Natl Acad Sci U S A 104: 1604-1609. (Pubitemid 46214637)
41. Tang B, Xiao B, Liu Z, Li N, Zhu ED, et al. (2010) Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett 584: 1481-1486.
42. Li T, Morgan MJ, Choksi S, Zhang Y, Kim YS, et al. (2010) MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation. Nat Immunol 11: 799-805.
43. Gottipati S, Rao NL, Fung-Leung W-P (2008) IRAK1: a critical signaling mediator of innate immunity. Cellular signalling 20: 269-276.
44. Lewin A, Freytag B, Meister B, Sharbati-Tehrani S, Schafer H, et al. (2003) Use of a quantitative TaqMan-PCR for the fast quantification of mycobacteria in broth culture, eukaryotic cell culture and tissue. J Vet Med B Infect Dis Vet Public Health 50: 505-509. (Pubitemid 38062079)
45. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, et al. (2006) The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 7: 3.
46. Pfaffl MW (2001) A new mathematical model for relative quantification in realtime RT-PCR. Nucleic Acids Res 29: e45.