Interleukin-37 ameliorates myocardial ischaemia/reperfusion injury in mice

Clinical and Experimental Immunology

Volumn 176, Issue 3, 2014, Pages 438-451

  Wu, B ^a   Meng, K ^a   Ji, Q ^b,c   Cheng, M ^a   Yu, K ^a   Zhao, X ^a   Tony, H ^a   Liu, Y ^a   Zhou, Y ^b   Chang, C ^b   Zhong, Y ^a   Zhu, Z ^a   Zhang, W ^a   Mao, X ^a   Zeng, Q ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c PEOPLE'S HOSPITAL OF GUANGXI ZHUANG AUTONOMOUS REGION   (China)

Author keywords

Apoptosis; I R injury; IL 37; ROS; TLR 4 NF B

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT INTERLEUKIN 37; TOLL LIKE RECEPTOR 4; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; INFLAMMATION; INNATE IMMUNITY; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; UPREGULATION;

APOPTOSIS; I/R INJURY; IL-37; ROS; TLR-4/NF-ΚB;

ANIMALS; CELL MOVEMENT; CYTOKINES; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-10; MALE; MICE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NEUTROPHIL INFILTRATION; NEUTROPHILS; NF-KAPPA B; OXIDATIVE STRESS; TOLL-LIKE RECEPTOR 4;

EID: 84899123771     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/cei.12284     Document Type: Article

References (52)

1. Arslan F, de Kleijn DP, Pasterkamp G. Innate immune signaling in cardiac ischemia. Nat Rev Cardiol 2011; 8:292-300.
2. Li Y, Si R, Feng Y etal. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem 2011; 286:31308-31319.
3. Oyama J, Blais C, Jr, Liu X etal. Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 2004; 109:784-789.
4. Timmers L, Pasterkamp G, de Hoog VC, Arslan F, Appelman Y, de Kleijn DP. The innate immune response in reperfused myocardium. Cardiovasc Res 2012; 94:276-283.
5. Boyd JH, Mathur S, Wang Y, Bateman RM, Walley KR. Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-kappaB dependent inflammatory response. Cardiovasc Res 2006; 72:384-393.
6. Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003; 300:1524-1525.
7. Ao L, Zou N, Cleveland JC, Jr, Fullerton DA, Meng X. Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70. Am J Physiol Heart Circ Physiol 2009; 297:H21-28.
8. Kaminski KA, Bonda TA, Korecki J, Musial WJ. Oxidative stress and neutrophil activation-the two keystones of ischemia/reperfusion injury. Int J Cardiol 2002; 86:41-59.
9. Frangogiannis NG. Chemokines in ischemia and reperfusion. Thromb Haemost 2007; 97:738-747.
10. Shimamoto A, Chong AJ, Yada M etal. Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury. Circulation 2006; 114:I270-274.
11. Cao Z, Hu Y, Wu W etal. The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injury. Cardiovasc Res 2009; 84:442-451.
12. Moss NC, Stansfield WE, Willis MS, Tang RH, Selzman CH. IKKbeta inhibition attenuates myocardial injury and dysfunction following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2007; 293:H2248-2253.
13. Tsung A, Klune JR, Zhang X etal. HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling. J Exp Med 2007; 204:2913-2923.
14. Fan J, Li Y, Levy RM etal. Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol 2007; 178:6573-6580.
15. Tete S, Tripodi D, Rosati M etal. IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation. Int J Immunopathol Pharmacol 2012; 25:31-38.
16. Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. IL-37 is a fundamental inhibitor of innate immunity. Nat Immunol 2010; 11:1014-1022.
17. Bufler P, Gamboni-Robertson F, Azam T, Kim SH, Dinarello CA. Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide. Biochem J 2004; 381:503-510.
18. McNamee EN, Masterson JC, Jedlicka P etal. Interleukin 37 expression protects mice from colitis. Proc Natl Acad Sci USA 2011; 108:16711-16716.
19. Sakai N, Van Sweringen HL, Belizaire RM etal. Interleukin-37 reduces liver inflammatory injury via effects on hepatocytes and non-parenchymal cells. J Gastroenterol Hepatol 2012; 27:1609-1616.
20. Ji QW, Zeng QT, Huang Y etal. Elevated plasma IL-37, IL-18 and IL-18BP concentrations in patients with acute coronary syndrome. Mediators Inflamm 2014; 2014: Article ID 165742, 9 pages.
21. Dandapat A, Hu CP, Li D etal. Overexpression of TGFbeta1 by adeno-associated virus type-2 vector protects myocardium from ischemia-reperfusion injury. Gene Ther 2008; 15:415-423.
22. Matsushima S, Kuroda J, Ago T etal. Broad suppression of NADPH oxidase activity exacerbates ischemia/reperfusion injury through inadvertent downregulation of hypoxia-inducible factor-1alpha and upregulation of peroxisome proliferator-activated receptor-alpha. Circ Res 2013; 112:1135-1149.
23. Liao YH, Xia N, Zhou SF etal. Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J Am Coll Cardiol 2012; 59:420-429.
24. Oh YB, Ahn M, Lee SM etal. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med 2013; 45:e23.
25. Zhou SL, Dai Z, Zhou ZJ etal. Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma. Hepatology 2012; 56:2242-2254.
26. Fliss H, Gattinger D. Apoptosis in ischemic and reperfused rat myocardium. Circ Res 1996; 79:949-956.
27. Yang Z, Zingarelli B, Szabo C. Crucial role of endogenous interleukin-10 production in myocardial ischemia/reperfusion injury. Circulation 2000; 101:1019-1026.
28. Ke B, Shen XD, Tsuchihashi S etal. Viral interleukin-10 gene transfer prevents liver ischemia-reperfusion injury: toll-like receptor-4 and heme oxygenase-1 signaling in innate and adaptive immunity. Hum Gene Ther 2007; 18:355-366.
29. Hamacher-Brady A, Brady NR, Gottlieb RA. The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy. Cardiovasc Drugs Ther 2006; 20:445-462.
30. Eltzschig HK, Eckle T. Ischemia and reperfusion-from mechanism to translation. Nat Med 2011; 17:1391-1401.
31. Ding HS, Yang J, Chen P, Bo SQ, Ding JW, Yu QQ. The HMGB1-TLR4 axis contributes to myocardial ischemia/reperfusion injury via regulation of cardiomyocyte apoptosis. Gene 2013; 527:389-393.
32. Kang PM, Haunstetter A, Aoki H, Usheva A, Izumo S. Morphological and molecular characterization of adult cardiomyocyte apoptosis during hypoxia and reoxygenation. Circ Res 2000; 87:118-125.
33. Becker LB. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res 2004; 61:461-470.
34. Yin Y, Guan Y, Duan J etal. Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. Eur J Pharmacol 2013; 699:219-226.
35. Raedschelders K, Ansley DM, Chen DD. The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion. Pharmacol Ther 2012; 133:230-255.
36. Wang M, Markel TA, Meldrum DR. Interleukin 18 in the heart. Shock 2008; 30:3-10.
37. Venkatachalam K, Prabhu SD, Reddy VS, Boylston WH, Valente AJ, Chandrasekar B. Neutralization of interleukin-18 ameliorates ischemia/reperfusion-induced myocardial injury. J Biol Chem 2009; 284:7853-7865.
38. Kaur K, Sharma AK, Dhingra S, Singal PK. Interplay of TNF-alpha and IL-10 in regulating oxidative stress in isolated adult cardiac myocytes. J Mol Cell Cardiol 2006; 41:1023-1030.
39. Rhee SH, Hwang D. Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J Biol Chem 2000; 275:34035-34040.
40. McCartney-Francis N, Jin W, Wahl SM. Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway. J Immunol 2004; 172:3814-3821.
41. Ago T, Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res 2006; 98:294-297.
42. Li SZ, Hong J, Nold MF etal. Recombinant IL-37 inhibits LPS induced inflammation in a SIGIRR- and MAPK-dependent manner [Abstract]. Cytokine 2013; 63:281.
43. Nold MF, Nold CA, Lo C etal. Interleukin 37 employs the IL-1 family inhibitory receptor SIGIRR and the alpha chain of the IL-18 receptor to suppress innate immunity [Abstract]. Cytokine 2013; 63:287.
44. Garlanda C, Anders HJ, Mantovani A. TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization. Trends Immunol 2009; 30:439-446.
45. Saccani S, Pantano S, Natoli G. p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol 2002; 3:69-75.
46. Huang X, Hazlett LD, Du W, Barrett RP. SIGIRR promotes resistance against Pseudomonas aeruginosa keratitis by down-regulating type-1 immunity and IL-1R1 and TLR4 signaling. J Immunol 2006; 177:548-556.
47. Ammirati E, Cannistraci CV, Cristell NA etal. Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6- interleukin-10+ cytokine patterns in ST-elevation acute myocardial infarction. Circ Res 2012; 111:1336-1348.
48. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19:683-765.
49. Ammirati E, Cianflone D, Banfi M etal. Circulating CD4+CD25hiCD127lo regulatory T-Cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis. Arterioscler Thromb Vasc Biol 2010; 30:1832-1841.
50. Burchfield JS, Iwasaki M, Koyanagi M etal. Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction. Circ Res 2008; 103:203-211.
51. Dominguez-Rodriguez A, Abreu-Gonzalez P, de la Rosa A, Vargas M, Ferrer J, Garcia M. Role of endogenous interleukin-10 production and lipid peroxidation in patients with acute myocardial infarction treated with primary percutaneous transluminal coronary angioplasty, interleukin-10 and primary angioplasty. Int J Cardiol 2005; 99:77-81.
52. Zhang J, Cheng X, Liao YH etal. Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction. Cardiovasc Drugs Ther 2005; 19:13-21.