메뉴 건너뛰기




Volumn 45, Issue 5, 2013, Pages

Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice

Author keywords

Apoptosis; Infiltration; Ischemia reperfusion; JAK3; JANEX 1

Indexed keywords

4 (4 HYDROXYANILINO) 6,7 DIMETHOXYQUINAZOLINE; CASPASE 3; CASPASE 9; CREATINE KINASE; INTERLEUKIN 8; JANUS KINASE 3; LACTATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN BAX; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE; JAK3 PROTEIN, MOUSE; QUINAZOLINE DERIVATIVE;

EID: 84881170395     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.1038/emm.2013.43     Document Type: Article
Times cited : (31)

References (41)
  • 1
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K et al. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009; 119: 480-486.
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3    De Simone, G.4    Ferguson, T.B.5    Flegal, K.6
  • 2
    • 77955444881 scopus 로고    scopus 로고
    • Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy
    • Turer AT, Hill JA. Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol 2010; 106: 360-368.
    • (2010) Am J Cardiol , vol.106 , pp. 360-368
    • Turer, A.T.1    Hill, J.A.2
  • 3
    • 79952814729 scopus 로고    scopus 로고
    • Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion
    • Zhang Y, Sun Q, He B, Xiao J, Wang Z, Sun X. Anti-inflammatory effect of hydrogen-rich saline in a rat model of regional myocardial ischemia and reperfusion. Int J Cardiol 2011; 148: 91-95.
    • (2011) Int J Cardiol , vol.148 , pp. 91-95
    • Zhang, Y.1    Sun, Q.2    He, B.3    Xiao, J.4    Wang, Z.5    Sun, X.6
  • 4
    • 57649103162 scopus 로고    scopus 로고
    • Human cord blood mononuclear cells decrease cytokines and inflammatory cells in acute myocardial infarction
    • Henning RJ, Shariff M, Eadula U, Alvarado F, Vasko M, Sanberg PR et al. Human cord blood mononuclear cells decrease cytokines and inflammatory cells in acute myocardial infarction. Stem Cells Dev 2008; 17: 1207-1219.
    • (2008) Stem Cells Dev , vol.17 , pp. 1207-1219
    • Henning, R.J.1    Shariff, M.2    Eadula, U.3    Alvarado, F.4    Vasko, M.5    Sanberg, P.R.6
  • 8
    • 0035902571 scopus 로고    scopus 로고
    • JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion
    • Mascareno E, El-Shafei M, Maulik N, Sato M, Guo Y, Das DK et al. JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion. Circulation 2001; 104: 325-329.
    • (2001) Circulation , vol.104 , pp. 325-329
    • Mascareno, E.1    El-Shafei, M.2    Maulik, N.3    Sato, M.4    Guo, Y.5    Das, D.K.6
  • 9
    • 0029865748 scopus 로고    scopus 로고
    • Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells
    • Gurniak CB, Berg LJ. Murine JAK3 is preferentially expressed in hematopoietic tissues and lymphocyte precursor cells. Blood 1996; 87: 3151-3160.
    • (1996) Blood , vol.87 , pp. 3151-3160
    • Gurniak, C.B.1    Berg, L.J.2
  • 10
    • 11144343254 scopus 로고    scopus 로고
    • Janus kinase 3: A novel target for selective transplant immunosupression
    • Podder H, Kahan BD. Janus kinase 3: a novel target for selective transplant immunosupression. Expert Opin Ther Targets 2004; 8: 613-629.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 613-629
    • Podder, H.1    Kahan, B.D.2
  • 13
    • 79961239419 scopus 로고    scopus 로고
    • Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats
    • Kim BH, Kim M, Yin CH, Jee JG, Sandoval C, Lee H et al. Inhibition of the signalling kinase JAK3 alleviates inflammation in monoarthritic rats. Br J Pharmacol 2011; 164: 106-118.
    • (2011) Br J Pharmacol , vol.164 , pp. 106-118
    • Kim, B.H.1    Kim, M.2    Yin, C.H.3    Jee, J.G.4    Sandoval, C.5    Lee, H.6
  • 14
    • 68149182278 scopus 로고    scopus 로고
    • JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice
    • Chang BY, Zhao F, He X, Ren H, Braselmann S, Taylor V et al. JAK3 inhibition significantly attenuates psoriasiform skin inflammation in CD18 mutant PL/J mice. J Immunol 2009; 183: 2183-2192.
    • (2009) J Immunol , vol.183 , pp. 2183-2192
    • Chang, B.Y.1    Zhao, F.2    He, X.3    Ren, H.4    Braselmann, S.5    Taylor, V.6
  • 15
    • 0037360589 scopus 로고    scopus 로고
    • Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice
    • Cetkovic-Cvrlje M, Dragt AL, Vassilev A, Liu XP, Uckun FM. Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice. Clin Immunol 2003; 106: 213-225.
    • (2003) Clin Immunol , vol.106 , pp. 213-225
    • Cetkovic-Cvrlje, M.1    Dragt, A.L.2    Vassilev, A.3    Liu, X.P.4    Uckun, F.M.5
  • 16
    • 67349091264 scopus 로고    scopus 로고
    • JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-κB activation and the JAK/STAT pathway
    • Lv N, Kim EK, Song MY, Choi HN, Moon WS, Park SJ et al. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-κB activation and the JAK/STAT pathway. Exp Cell Res 2009; 315: 2064-2071.
    • (2009) Exp Cell Res , vol.315 , pp. 2064-2071
    • Lv, N.1    Kim, E.K.2    Song, M.Y.3    Choi, H.N.4    Moon, W.S.5    Park, S.J.6
  • 18
    • 33746859331 scopus 로고    scopus 로고
    • The JAK/STAT pathway is essential for opioidinduced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3b
    • Gross ER, Hsu AK, Gross GJ. The JAK/STAT pathway is essential for opioidinduced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3b. Am J Physiol Heart Circ Physiol 2006; 291: H827-H834.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Gross, E.R.1    Hsu, A.K.2    Gross, G.J.3
  • 19
    • 79960448766 scopus 로고    scopus 로고
    • Aggravation of post-ischemic liver injury by overexpression of A20, an NF-κB suppressor
    • Yu J, Lee HS, Lee SM, Yu HC, Moon WS, Chung MJ et al. Aggravation of post-ischemic liver injury by overexpression of A20, an NF-κB suppressor. J Hepatol 2011; 55: 328-336.
    • (2011) J Hepatol , vol.55 , pp. 328-336
    • Yu, J.1    Lee, H.S.2    Lee, S.M.3    Yu, H.C.4    Moon, W.S.5    Chung, M.J.6
  • 20
    • 79952070818 scopus 로고    scopus 로고
    • Ischemia/reperfusion injury: The benefit of having STAT3 in the heart
    • Boengler K. Ischemia/reperfusion injury: the benefit of having STAT3 in the heart. J Mol Cell Cardiol 2011; 50: 587-588.
    • (2011) J Mol Cell Cardiol , vol.50 , pp. 587-588
    • Boengler, K.1
  • 22
    • 0033838783 scopus 로고    scopus 로고
    • Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction
    • Negoro S, Kunisada K, Tone E, Funamoto M, Oh H, Kishimoto T et al. Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarction. Cardiovasc Res 2000; 47: 797-805.
    • (2000) Cardiovasc Res , vol.47 , pp. 797-805
    • Negoro, S.1    Kunisada, K.2    Tone, E.3    Funamoto, M.4    Oh, H.5    Kishimoto, T.6
  • 23
    • 35348976052 scopus 로고    scopus 로고
    • Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling
    • Wang M, Zhang W, Crisostomo P, Markel T, Meldrum KK, Fu XY et al. Endothelial STAT3 plays a critical role in generalized myocardial proinflammatory and proapoptotic signaling. Am J Physiol Heart Circ Physiol 2007; 293: H2101-H2108.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Wang, M.1    Zhang, W.2    Crisostomo, P.3    Markel, T.4    Meldrum, K.K.5    Fu, X.Y.6
  • 24
    • 0034085912 scopus 로고    scopus 로고
    • Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters
    • Stephanou A, Brar BK, Knight RA, Latchman DS. Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters. Cell Death Differ 2000; 7: 329-330.
    • (2000) Cell Death Differ , vol.7 , pp. 329-330
    • Stephanou, A.1    Brar, B.K.2    Knight, R.A.3    Latchman, D.S.4
  • 25
    • 0034616164 scopus 로고    scopus 로고
    • Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis
    • Stephanou A, Brar BK, Scarabelli TM, Jonassen AK, Yellon DM, Marber MS et al. Ischemia-induced STAT-1 expression and activation play a critical role in cardiomyocyte apoptosis. J Biol Chem 2000; 275: 10002-10008.
    • (2000) J Biol Chem , vol.275 , pp. 10002-10008
    • Stephanou, A.1    Brar, B.K.2    Scarabelli, T.M.3    Jonassen, A.K.4    Yellon, D.M.5    Marber, M.S.6
  • 26
    • 41749084405 scopus 로고    scopus 로고
    • RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model
    • Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W et al. RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol 2008; 294: H1823-H1832.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Aleshin, A.1    Ananthakrishnan, R.2    Li, Q.3    Rosario, R.4    Lu, Y.5    Qu, W.6
  • 27
    • 1142309740 scopus 로고    scopus 로고
    • Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
    • Vinten-Johansen J. Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury. Cardiovasc Res 2004; 61: 481-497.
    • (2004) Cardiovasc Res , vol.61 , pp. 481-497
    • Vinten-Johansen, J.1
  • 28
    • 80955144444 scopus 로고    scopus 로고
    • Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion
    • Calvillo L, Vanoli E, Andreoli E, Besana A, Omodeo E, Gnecchi M et al. Vagal stimulation, through its nicotinic action, limits infarct size and the inflammatory response to myocardial ischemia and reperfusion. J Cardiovasc Pharmacol 2011; 58: 500-507.
    • (2011) J Cardiovasc Pharmacol , vol.58 , pp. 500-507
    • Calvillo, L.1    Vanoli, E.2    Andreoli, E.3    Besana, A.4    Omodeo, E.5    Gnecchi, M.6
  • 29
    • 0035181640 scopus 로고    scopus 로고
    • Apoptosis in the ischemic reperfused myocardium
    • Holleyman CR, Larson DF. Apoptosis in the ischemic reperfused myocardium. Perfusion 2001; 16: 491-502.
    • (2001) Perfusion , vol.16 , pp. 491-502
    • Holleyman, C.R.1    Larson, D.F.2
  • 30
    • 79955057670 scopus 로고    scopus 로고
    • Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK
    • Xu H, Yao Y, Su Z, Yang Y, Kao R, Martin CM et al. Endogenous HMGB1 contributes to ischemia-reperfusion-induced myocardial apoptosis by potentiating the effect of TNF-α/JNK. Am J Physiol Heart Circ Physiol 2011; 300: H913-H921.
    • (2011) Am J Physiol Heart Circ Physiol , vol.300
    • Xu, H.1    Yao, Y.2    Su, Z.3    Yang, Y.4    Kao, R.5    Martin, C.M.6
  • 31
    • 11144287220 scopus 로고    scopus 로고
    • Apoptosis of ventricular myocytes: A means to an end
    • Regula KM, Kirshenbaum LA. Apoptosis of ventricular myocytes: a means to an end. J Mol Cell Cardiol 2005; 38: 3-13.
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 3-13
    • Regula, K.M.1    Kirshenbaum, L.A.2
  • 32
    • 84872437664 scopus 로고    scopus 로고
    • Inhibition of nicotinamide phosphoribosyltransferase (Nampt) reduces neutrophil-mediated injury in myocardial infarction
    • Montecucco F, Bauer I, Braunersreuther V, Bruzzone S, Akhmedov A, Luscher TF et al. Inhibition of nicotinamide phosphoribosyltransferase (Nampt) reduces neutrophil-mediated injury in myocardial infarction. Antioxid Redox Signal 2013; 18: 630-641.
    • (2013) Antioxid Redox Signal , vol.18 , pp. 630-641
    • Montecucco, F.1    Bauer, I.2    Braunersreuther, V.3    Bruzzone, S.4    Akhmedov, A.5    Luscher, T.F.6
  • 33
    • 77953959767 scopus 로고    scopus 로고
    • Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice
    • Montecucco F, Lenglet S, Braunersreuther V, Pelli G, Pellieux C, Montessuit C et al. Single administration of the CXC chemokine-binding protein Evasin-3 during ischemia prevents myocardial reperfusion injury in mice. Arterioscler Thromb Vasc Biol 2010; 30: 1371-1377.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1371-1377
    • Montecucco, F.1    Lenglet, S.2    Braunersreuther, V.3    Pelli, G.4    Pellieux, C.5    Montessuit, C.6
  • 34
    • 0032984889 scopus 로고    scopus 로고
    • Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1
    • Ono K, Matsumori A, Furukawa Y, Igata H, Shioi T, Matsushima K et al. Prevention of myocardial reperfusion injury in rats by an antibody against monocyte chemotactic and activating factor/monocyte chemoattractant protein-1. Lab Invest 1999; 79: 195-203.
    • (1999) Lab Invest , vol.79 , pp. 195-203
    • Ono, K.1    Matsumori, A.2    Furukawa, Y.3    Igata, H.4    Shioi, T.5    Matsushima, K.6
  • 35
    • 0026005681 scopus 로고
    • Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion
    • Dreyer WJ, Michael LH, West MS, Smith CW, Rothlein R, Rossen RD et al. Neutrophil accumulation in ischemic canine myocardium. Insights into time course, distribution, and mechanism of localization during early reperfusion. Circulation 1991; 84: 400-411.
    • (1991) Circulation , vol.84 , pp. 400-411
    • Dreyer, W.J.1    Michael, L.H.2    West, M.S.3    Smith, C.W.4    Rothlein, R.5    Rossen, R.D.6
  • 36
    • 16944366340 scopus 로고    scopus 로고
    • Complement C5a, TGF-β1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion
    • Birdsall HH, Green DM, Trial J, Youker KA, Burns AR, MacKay CR et al. Complement C5a, TGF-β1, and MCP-1, in sequence, induce migration of monocytes into ischemic canine myocardium within the first one to five hours after reperfusion. Circulation 1997; 95: 684-692.
    • (1997) Circulation , vol.95 , pp. 684-692
    • Birdsall, H.H.1    Green, D.M.2    Trial, J.3    Youker, K.A.4    Burns, A.R.5    MacKay, C.R.6
  • 37
    • 0030994661 scopus 로고    scopus 로고
    • Plasma levels of the monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 are elevated in patients with acute myocardial infarction
    • Matsumori A, Furukawa Y, Hashimoto T, Yoshida A, Ono K, Shioi T et al. Plasma levels of the monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 are elevated in patients with acute myocardial infarction. J Mol Cell Cardiol 1997; 29: 419-423.
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 419-423
    • Matsumori, A.1    Furukawa, Y.2    Hashimoto, T.3    Yoshida, A.4    Ono, K.5    Shioi, T.6
  • 38
    • 33644588726 scopus 로고    scopus 로고
    • CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemia-reperfusion in mice
    • Hayasaki T, Kaikita K, Okuma T, Yamamoto E, Kuziel WA, Ogawa H et al. CC chemokine receptor-2 deficiency attenuates oxidative stress and infarct size caused by myocardial ischemia-reperfusion in mice. Circ J 2006; 70: 342-351.
    • (2006) Circ J , vol.70 , pp. 342-351
    • Hayasaki, T.1    Kaikita, K.2    Okuma, T.3    Yamamoto, E.4    Kuziel, W.A.5    Ogawa, H.6
  • 41
    • 16844387569 scopus 로고    scopus 로고
    • Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium
    • Kumar AG, Ballantyne CM, Michael LH, Kukielka GL, Youker KA, Lindsey ML et al. Induction of monocyte chemoattractant protein-1 in the small veins of the ischemic and reperfused canine myocardium. Circulation 1997; 95: 693-700.
    • (1997) Circulation , vol.95 , pp. 693-700
    • Kumar, A.G.1    Ballantyne, C.M.2    Michael, L.H.3    Kukielka, G.L.4    Youker, K.A.5    Lindsey, M.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.