Structural basis for the evolution of vancomycin resistance D,D-peptidases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 16, 2014, Pages 5872-5877

  Meziane Cherif, Djalal ^a   Stogios, Peter J ^b,c   Evdokimova, Elena ^b,c   Savchenko, Alexei ^b,c   Courvalin, Patrice ^a  

^a INSTITUT PASTEUR   (France)

^b UNIVERSITY OF TORONTO   (Canada)

^c Center for Structural Genomics of Infectious Diseases (CSGID)   (Canada)

Author keywords

Antibiotic resistance; Enzyme evolution; Glycopeptides; Metallopeptidases; Subfamily M15B

Indexed keywords

AMINOPEPTIDASE; BACTERIAL ENZYME; CARBOXYPEPTIDASE; D,D AMINOPEPTIDASE; D,D CARBOXYPEPTIDASE; D,D PEPTIDASE; PEPTIDASE; UNCLASSIFIED DRUG; VANXY ENZYME;

AMINO TERMINAL SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; GEL PERMEATION CHROMATOGRAPHY; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; PRIORITY JOURNAL; STRUCTURE GUIDED MUTAGENESIS;

ANTIBIOTIC RESISTANCE; ENZYME EVOLUTION; GLYCOPEPTIDES; METALLOPEPTIDASES; SUBFAMILY M15B;

ALANINE; BINDING SITES; DNA MUTATIONAL ANALYSIS; EVOLUTION, MOLECULAR; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS; SERINE-TYPE D-ALA-D-ALA CARBOXYPEPTIDASE; SUBSTRATE SPECIFICITY; VANCOMYCIN; VANCOMYCIN RESISTANCE;

EID: 84899110665     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402259111     Document Type: Article

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