Circulating dendritic cells of multiple sclerosis patients are proinflammatory and their frequency is correlated with MS-associated genetic risk factors

Multiple Sclerosis Journal

Volumn 20, Issue 5, 2014, Pages 548-557

  Thewissen, Kristof ^a   Nuyts, Amber H ^b   Deckx, Nathalie ^b   Wijmeersch, Bart Van ^a,b,c   Nagels, Guy ^e   D'Hooghe, Marie ^e   Willekens, Barbara ^f   Cras, Patrick ^f   Eijnde, Bert O ^a,d   Goossens, Herman ^b   Van Tendeloo, Viggo Fi ^b   Stinissen, Piet ^a   Berneman, Zwi N ^b   Hellings, Niels ^a   Cools, Nathalie ^b  

^a HASSELT UNIVERSITY   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c Revalidation and MS Center   (Belgium)

^d Department Healthcare REVAL Rehabilitation Research Center   (Belgium)

^e National MS Center   (Belgium)

^f ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

costimulatory molecules; Dendritic cells; migration; MS associated genetic risk factors; multiple sclerosis

Indexed keywords

GAMMA INTERFERON; HLA DRB1 ANTIGEN; INTERLEUKIN 12P70; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; ALPHA INTERFERON; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR7; INTERLEUKIN 7 RECEPTOR ALPHA; L SELECTIN; CCR5 PROTEIN, HUMAN; CCR7 PROTEIN, HUMAN; HLA-DRB1*15:01 ANTIGEN; IL17RA PROTEIN, HUMAN; INTERLEUKIN 17 RECEPTOR; TOLL LIKE RECEPTOR;

ADULT; AGED; ARTICLE; CELL POPULATION; CONTROLLED STUDY; DENDRITIC CELL; EX VIVO STUDY; FEMALE; FLOW CYTOMETRY; GENETIC RISK; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; PHENOTYPE; PROMOTER REGION; UPREGULATION; ADAPTIVE IMMUNITY; CHEMOTAXIS; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; INNATE IMMUNITY; NEUROPATHOLOGY; PLASMACYTOID DENDRITIC CELL; PROTEIN EXPRESSION; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; CELL CULTURE; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; AGED; CASE-CONTROL STUDIES; CELLS, CULTURED; CHEMOTAXIS; DENDRITIC CELLS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HLA-DRB1 CHAINS; HUMANS; IMMUNITY, INNATE; INFLAMMATION; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; PHENOTYPE; RECEPTORS, CCR5; RECEPTORS, CCR7; RECEPTORS, INTERLEUKIN-17; RISK FACTORS; TOLL-LIKE RECEPTORS; YOUNG ADULT;

EID: 84899094125     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458513505352     Document Type: Article

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