An experimental study of micromilling parameters to manufacture microchannels on a PMMA substrate

International Journal of Advanced Manufacturing Technology

Volumn 71, Issue 9-12, 2014, Pages 1623-1630

  Chen, Pin Chuan ^a   Pan, Chang Wei ^a   Lee, Wei Chen ^a   Li, Kuan Ming ^b  

^a NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Micromilling; Polymer microfluidic device; Rapid prototyping

Indexed keywords

COMPRESSED AIR; COOLANTS; FACTOR ANALYSIS; FLUIDIC DEVICES; MANUFACTURE; MICROFLUIDICS; MICROMACHINING; MILLING (MACHINING); MULTIVARIANT ANALYSIS; POLYMERS; POLYMETHYL METHACRYLATES; RAPID PROTOTYPING; SURFACE PROPERTIES; USER INTERFACES;

APPLICATION FIELDS; COMPLICATED STRUCTURES; DISEASE DETECTION; ENVIRONMENTAL MONITORING; FABRICATION PROCESS; MICRO MILLING; POLYMER MICROFLUIDIC DEVICES; SUBSTRATE MATERIAL;

SUBSTRATES;

EID: 84899072634     PISSN: 02683768     EISSN: 14333015     Source Type: Journal    
DOI: 10.1007/s00170-013-5555-z     Document Type: Article

References (23)

1. Terry SC, Jerman JH, Angell JB (1979) A gas chromatographic air analyzer fabricated on a silicon wafer. IEEE Trans Electron Devices 26:1880-1886
2. Yager P, Edwards T, Fu E, Helton K, Nelson K, Tam M, Weigl BH (2006) Microfluidic diagnostic technologies for global public health. Nature 442:412-418
3. Whitesides GM (2006) The origins and future of microfluidics. Nature 442:68-373
4. Roberson BH, Nicholson KA (2005) New microbiology tools for public health and their implications. Annu Rev Public Health 26:281-302
5. Dornfeld D, Min S, Takeuchi Y (2006) Recent advances in mechanical micromachining. CIRP Ann Manuf Technol 55:745-768
6. Xu BY, Yan XN, Zhang JD, Xu JJ, Chen HY (2012) Glass etching to bridge micro- and nanofluidics. Lab Chip 12:381
7. Park DS, Chen PC, You BH, Kim N, Park T, Lee TY, Datta P, Desta Y, Soper SA, Nikitopoulos DE, Murphy MC (2010) Titer-plate formatted continuous flow thermal reactors for highthroughput applications: fabrication and test. J Micromech Microeng 20:055003
8. Chen PC, Park DS, You BH, Kim N, Park T, Soper SA, Nikitopoulos DE, Murphy MC (2010) Titer-plate formatted continuous flow thermal reactors: design and performance of a nanoliter reactor. Sensors Actuators B 149:291-300
9. Kim JA, Lee JY, Seong S, Cha SH, Lee SH, Kim JJ, Park TH (2006) Fabrication and characterization of a PDMS-glass hybrid continuous flow PCR chip. Biochem Eng J 29:91-97
10. Soper SA, Ford SM, Qi S, McCarley RL, Kelly K, Murphy MC (2000) Polymeric microelectromechanical systems. Anal Chem 72:643A-651A
11. Mecomber JS, Hurd D, Limbach PA (2005) Enhanced machining of micron-scale features in microchip molding masters by CNC milling. Int J Mach Tools Manuf 45:1542-1550
12. Sooraj VS, Jose M (2011) An experimental investigation on the machining characteristics of microscale end milling. Int J Adv Manuf Technol 56:951-958
13. Mecomber JS, Stalcup AM, Hurd D, Halsall HB, Heineman WR, Seliskar CJ, Wehmeyer KR, Limbach PA (2006) Analytical performance of polymer-based microfluidic devices fabricated by computer numerical controlled machining. Anal Chem 78:936-941
14. Becker H, Heim U (2000) Hot embossing as a method for the fabrication of polymer high aspect ratio structures. Sensors Actuators A 83:30-135
15. Becker H, Gartner C (2001) Polymer based micro-reactors. Rev Mol Biotechnol 82:89-99
16. Hupert ML, Guy WJ, Llopis SD, Shadpour H, Rani S, Nikitopoulos DE, Soper SA (2007) Evaluation of micromilled metal mold masters for the replication of microchip electrophoresis devices. Microfluid Nanofluid 3:1-11
17. Vazquez E, Rodriguez CA, Elias-Zuniga A, Ciurana J (2010) An experimental analysis of process parameters to manufacture metallic micro-channels by micro-milling. Int J Adv Manuf Technol 51:945-955
18. Zhang JZ, Chen JC, Kirby ED (2007) Surface roughness optimization in an end-milling operation using the Taguchi design method. J Mater Process Technol 184:233-239
19. Ko JS, Yoon HC, Yang H, Pyo HB, Chung KH, Kim SJ, Kim YT (2003) A polymer-based microfluidic device for immunosensing biochips. Lab Chip 3:106-113
20. Wei CW, Cheng JY, Huang CT, Yen MH, Young TH (2005) Using a microfluidic device for 1 μl DNA microarray hybridization in 500 S. Nucleic Acids Res 33(8):e78
21. Spyro Plastics Ltd. (2005) http://www.spyroplastics.com/. Accessed 4 Nov 2013
22. Rahman M, Senthil Kumar A, Salam MU (2002) Experimental evaluation on the effect of minimal quantities of lubricant in milling. Int J Mach Tools Manuf 42:539-547
23. Li KM, Lin CP (2012) Study on minimum quantity lubrication in micro-grinding. Int J Adv Manuf Technol 62:99-105