Titer-plate formatted continuous flow thermal reactors: Design and performance of a nanoliter reactor

Sensors and Actuators, B: Chemical

Volumn 149, Issue 1, 2010, Pages 291-300

  Chen, Pin Chuan ^a,b,c   Park, Daniel S ^a   You, Byoung Hee ^a,b,d   Kim, Namwon ^a,b   Park, Taehyun ^a,b   Soper, Steven A ^a   Nikitopoulos, Dimitris E ^a,b   Murphy, Michael C ^a,b  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b Louisiana State University   (United States)

^c SINGAPORE INSTITUTE OF MANUFACTURING TECHNOLOGY   (Singapore)

^d Texas State University   (United States)

Author keywords

96 Well PCR; CFPCR; High throughput PCR; Nano fluidic device; Thermal reactor

Indexed keywords

96-WELL; BIOCHEMICAL REACTIONS; CONTINUOUS FLOWS; COPY NUMBER; DNA FRAGMENT; DNA-TEMPLATE; FINITE ELEMENT MODELS; FOOT-PRINT DEVICES; FRAGMENT LENGTHS; GUIDE SYSTEM; HIGH THROUGHPUT; NANO-FLUIDIC DEVICES; NANOLITERS; OPTIMAL TEMPERATURE; RENATURATION; RESIDENCE TIME; SINGLE LOOP; TEMPERATURE CYCLING; TEMPERATURE GRADIENT; TEMPERATURE TOLERANCE; TEMPERATURE ZONE; THERMAL CYCLER; THERMAL ISOLATION; THERMAL MANAGEMENT; THERMAL PERFORMANCE; THERMAL REACTORS; THERMAL RESISTANCE; TRANSITION TIME;

DNA; FINITE ELEMENT METHOD; FLOW VELOCITY; FLUIDIC DEVICES; GENES; MICROCHANNELS; OPTIMIZATION; PLATES (STRUCTURAL COMPONENTS); POLYMERASE CHAIN REACTION; THROUGHPUT;

AMPLIFICATION;

EID: 77955466723     PISSN: 09254005     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.snb.2010.05.068     Document Type: Article

References (41)

1. B.H. Robertson, and K.A. Nicholson New microbiology tools for public health and their implications Annu. Rev. Public Health 26 2005 281 302
2. F.S. Collins, M. Morgan, and A. Patrinos The Human Genome Project: lessons from large-scale biology Science 300 2003 286 290
3. P. Grodzinski, R.H. Liu, B. Chen, J. Blackwell, Y. Liu, D. Rhine, T. Smekal, D. Ganser, C. Romero, H. Yu, T. Chan, and N. Kroutchinina Development of plastic microfluidic device for sample preparation Biomed. Microdevices 3 2001 275 283
4. K.B. Mullis, and F.A. Faloona Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction Methods Enzymol. 155 1987 335 350
5. M. Khanna, P. Park, M. Zirvi, W. Cao, A. Picon, J. Day, P. Paty, and F. Barany Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors Oncogene 18 1999 27 38
6. T.-Y. Lee, K. Han, D.S. Park, S.A. Soper, M.A. Batzer, D.E. Nikitopoulos, and M.C. Murphy A multifunction microfluidic module for mutation detection Proceedings of the 15th Annual IEEE International Conference on Solid State Sensors, Actuators, and Microsystems Denver, CO, June 21-26 2009 120 123
7. M. Hashimoto, P.C. Chen, M.W. Mitchell, D.E. Nikitopoulos, S.A. Soper, and M.C. Murphy Rapid PCR in a continuous flow device Lab. Chip 4 2004 638 645
8. M.U. Kopp, A.J. de Mello, and A. Manz Chemical amplification: continuous flow PCR on a chip Science 280 1998 1046 1048
9. P.-C. Chen, D.E. Nikitopoulos, S.A. Soper, and M.C. Murphy Temperature distribution effects on micro-CFPCR performance Biomed. Microdevices 10 2008 141 152
10. D.J. Sadler, R. Changrani, P. Roberts, C.F. Chou, and F. Zenhausern Thermal management of Bio-MEMS: temperature control for ceramic-based PCR and DNA detection devices IEEE Trans. Compon. Pack. Technol. 26 2003 309 316
11. P.J. Obeid, T.K. Christopoulos, H.J. Crabtree, and C.J. Backhouse Microfabricated device for DNA and RNA amplification by continuous-flow polymerase chain reaction and reverse transcription-polymerase chain reaction with cycle number selection Anal. Chem. 75 2003 288 295
12. N. Crews, C. Wittwer, and B. Gale Continuous-flow thermal gradient PCR Biomed. Microdevices 10 2008 187 195
13. N. Crews, C. Wittwer, R. Palais, and B. Gale Product differentiation during continuous-flow thermal gradient PCR Lab. Chip 8 2008 919 924
14. I. Erill, S. Campoy, J. Rus, L. Fonseca, A. Ivorra, Z. Navazzo, L.A. Plaza, J. Aguilo, and J. Barbe Development of a CMOS-compatible PCR chip: comparison of design and system strategies J. Micromech. Microeng. 14 2004 1558 1568
15. Y.S. Shin, K. Cho, S.H. Lim, S. Chung, S.J. Park, C. Chung, D.C. Han, and J.K. Chang PDMS-based micro PCR chip with parylene coating J. Micromech. Microeng. 13 2003 768 774
16. J.H. Daniel, S. Iqbal, R.B. Millington, D.F. Moore, C.R. Lowe, D.L. Leslie, M.A. Lee, and M.J. Pearce Silicon microchambers for DNA amplification Sens. Actuators A 71 1998 81 88
17. B.C. Giordano, J. Ferrance, S. Swedberg, A.F.R. Huhmer, and J.P. Landers Polymerase chain reaction in polymeric microchips: DNA amplification in less than 240 s Anal. Biochem. 291 2001 124 132
18. R.P. Oda, M.A. Strausbauch, A.F.R. Huhmer, N. Borson, S.R. Jurrens, J. Craighead, P.J. Wettstein, B. Eckloff, B. Kline, and J.P. Landers Infrared mediated thermocycling for ultrafast polymerase chain reaction amplification of DNA Anal. Chem. 70 1998 4361 4368
19. H. Nagai, Y. Murakami, K. Yokoyama, and E. Tamiya High-throughput PCR in silicon based microchamber array Biosens. Bioelectron. 16 2001 1015 1019 (Pubitemid 33000229)
20. H. Nagai, Y. Murakami, Y. Morita, K. Yokoyama, and E. Tamiya Development of a microchamber array for picoliter PCR Anal. Chem. 73 2001 1043 1047 (Pubitemid 32204922)
21. Q. Zou, Y. Miao, Y. Chen, U. Sridhar, C.S. Chong, T. Chai, Y. Tie, C.H.L. Teh, T.M. Lim, and C.K. Heng Micro-assembled multi-chamber thermal cycler for low-cost reaction chip thermal multiplexing Sens. Actuators A 102 2002 114 121
22. Z.Q. Zou, X. Chen, Q.H. Jin, M.S. Yang, and J.L. Zhao A novel miniaturized PCR multi-reactor array fabricated using flip-chip bonding techniques J. Micromech. Microeng. 15 2005 1476 1481
23. S. Mohr, Y.H. Zhang, A. Macaskill, P.J.R. Day, R.W. Barber, N.J. Goddard, D.R. Emerson, and P.R. Fielden Numerical and experimental study of a droplet-based PCR chip Microfluids Nanofluids 3 2007 611 621
24. Y.C. Lin, C.C. Yang, and M.Y. Huang Simulation and experimental validation of micro polymerase chain reaction chips Sens. Actuators B 71 2000 127 133
25. D.S. Yoon, Y.S. Lee, Y. Lee, H.J. Cho, S.W. Sung, K.W. Oh, J. Cha, and G. Lim Precise temperature control and rapid thermal cycling in a micromachined DNA polymerase chain reaction chip J. Micromech. Microeng. 12 2002 813 823
26. J. El-Ali, I.R. Perch-Nielsen, C.R. Poulsen, D.D. Bang, P. Telleman, and A. Wolff Simulation and experimental validation of a SU-8 based PCR thermocycler chip with integrated heaters and temperature sensors Sens. Actuators A 110 2004 3 10
27. M. Yuan, R. Pal, and M.A. Burns Cost-effective thermal isolation techniques for use on microfabricated DNA amplification and analysis devices J. Micromech. Microeng. 15 2005 221 230
28. Q. Hao Analytical heat-transfer modeling of multilayered microdevices J. Micromech. Microeng. 14 2004 914 926
29. A.M. Chaudhari, T.M. Woudenberg, M. Albin, and K.E. Goodson Transient liquid crystal thermometry of microfabricated PCR vessel arrays JMEMS 7 1998 345 355
30. A. Iles, R. Fortt, and A.J. de Mello Thermal optimization of the Reimer-Tiemann reaction using thermochromic liquid crystals on a microfluidic reactor Lab. Chip 5 2005 540 544
31. J. Noh, S.W. Sung, M.K. Jeon, S.H. Kim, L.P. Lee, and S.I. Woo In situ thermal diagnostic of the micro-PCR system using liquid crystals Sens. Actuators A 122 2005 196 202
32. C.S. Liao, G.B. Lee, J.J. Wu, C.C. Chang, T.M. Hsien, F.C. Huang, and C.H. Luo Micromachined polymerase chain reaction system for multiple DNA amplification of upper respiratory tract infectious diseases Biosens. Bioelectron. 20 2005 1341 1348
33. D. Ross, M. Gaitan, and L.E. Locascio Temperature measurement in microfluidic systems using a temperature-dependent fluorescent dye Anal. Chem. 73 2001 4117 4123
34. D.S. Park, P.C. Chen, B.H. You, N. Kim, T. Park, P. Datta, Y. Desta, S. Soper, D.E. Nikitopoulos, and M.C. Murphy Titer-plate formatted continuous flow thermal reactors for high throughput applications J. Micromech. Microeng. 20 5 2010 055003-1 055003-11
35. Soc. Biomolecular Screening (SBS), ANSI/SBS 1-2004, SBS Microplate Stds Development Comm., Danbury, CT, 2004.
36. ANSYS CFD FLOTRAN Analysis Guide, 3rd, SAS Ip, Inc., 1997.
37. F.P. Incropera, and D.P. Dewitt Fundamentals of Heat and Mass Transfer 5th ed. 2001 John Wiley & Sons, Inc. Danvers (Appendix)
38. D.S.-W. Park, M.L. Hupert, M.A. Witek, B.H. You, P. Datta, J. Guy, J.B. Lee, S.A. Soper, D.E. Nikitopoulos, and M.C. Murphy A titer-plate based polymer microfluidic platform for high throughput nucleic acid purification Biomed. Microdevices 10 2008 21 33
39. M.L. Hupert, W.J. Guy, S.D. LIopis, H. Shadpour, S. Rani, D.E. Nikitopoulos, and S.A. Soper Evaluation of micromilled metal mold masters for the replication of microchip electrophoresis devices Microfluids Nanofluids 3 2007 1 11
40. M.A. Innis, K.B. Myambo, D.H. Gelfand, and M.A.D. Brow DNA sequencing with Thermus aquaticus DNA polymerase and direct sequencing of polymerase chain reaction-amplified DNA PNAS 85 1988 9436 9440
41. A. Gonzalez, R. Grimes, E.J. Walsh, T. Dalton, and M. Davies Interaction of quantitative PCR components with polymeric surfaces Biomed. Microdevices 9 2007 261 266