CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction

Arthritis Research and Therapy

Volumn 16, Issue 1, 2014, Pages

  Ito, Sayaka ^a   Hara, Yukichi ^a   Kubota, Tetsuo ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 8; COMPLEMENTARY DNA; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; MUTANT PROTEIN; PURINERGIC P2X7 RECEPTOR; REGULATOR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CARD8 PROTEIN, HUMAN; CARRIER PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; NLRP3 PROTEIN, HUMAN; TUMOR PROTEIN;

ARTICLE; CINCA SYNDROME; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION SYSTEM; GENE SILENCING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MACROPHAGE; MISSENSE MUTATION; MONOCYTE DERIVED MACROPHAGE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SINGLE NUCLEOTIDE POLYMORPHISM; WESTERN BLOTTING; WILD TYPE; GENETICS; HEK293 CELL LINE; METABOLISM; MONONUCLEAR CELL; MUTATION; NORMAL HUMAN; PROTEIN EXPRESSION;

CARD SIGNALING ADAPTOR PROTEINS; CARRIER PROTEINS; CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; INFLAMMASOMES; LEUKOCYTES, MONONUCLEAR; MUTATION; NEOPLASM PROTEINS; TRANSFECTION;

EID: 84899059917     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4483     Document Type: Article

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