Design, synthesis, and evaluation of novel fluoroquinolone-flavonoid hybrids as potent antibiotics against drug-resistant microorganisms

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 92-100

  Xiao, Zhu Ping ^a,b   Wang, Xu Dong ^a   Wang, Peng Fei ^b   Zhou, Yin ^a   Zhang, Jing Wen ^a   Zhang, Lei ^a   Zhou, Jiao ^a   Zhou, Sha Sha ^a   Hui, Ouyang ^a   Lin, Xiao Yi ^a   Mustapa, Manzira ^a   Reyinbaike, Asaimuguli ^a   Zhu, Hai Liang ^a,b  

^a JISHOU UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

DNA gyrase; Efflux pump; Flavonoid; Fluoroquinolone; Hybrid; Inhibitor

Indexed keywords

APIGENIN ETHYLIDENE CIPROFLOXACIN; APIGENIN ETHYLIDENE NORFLOXACIN; APIGENIN ETHYLIDENE SARAFLOXACIN; CHRYSIN ETHYLIDENE CIPROFLOXACIN; CHRYSIN ETHYLIDENE ENOXACIN; CHRYSIN ETHYLIDENE LOMEFLOXACIN; CHRYSIN ETHYLIDENE NORFLOXACIN; CHRYSIN ETHYLIDENE SARAFLOXACIN; CHRYSIN ETHYLIDENE SPARFLOXACIN; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); FLAVONOID; FORMONONETIN ETHYLIDENE NORFLOXACIN; FORMONONETIN ETHYLIDENE SARAFLOXACIN; GENISTIN ETHYLIDENE CIPROFLOXACIN; GENISTIN ETHYLIDENE ENOXACIN; GENISTIN ETHYLIDENE LOMEFLOXACIN; GENISTIN ETHYLIDENE NORFLOXACIN; GENISTIN ETHYLIDENE SARAFLOXACIN; NARINGENIN ETHYLIDENE CIPROFLOXACIN; NARINGENIN ETHYLIDENE ENOXACIN; NARINGENIN ETHYLIDENE LOMEFLOXACIN; NARINGENIN ETHYLIDENE NORFLOXACIN; NARINGENIN ETHYLIDENE SARAFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DNA SUPERCOILING; QUINOLONE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS SUBTILIS; CANDIDA ALBICANS; CONTROLLED STUDY; DNA SUPERCOILING; DRUG ACCUMULATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; MOLECULAR DOCKING; NONHUMAN; STAPHYLOCOCCUS AUREUS; BACTERIA; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MICROBIAL SENSITIVITY TEST; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-INFECTIVE AGENTS; BACTERIA; CANDIDA ALBICANS; CHEMISTRY TECHNIQUES, SYNTHETIC; DNA GYRASE; DNA, SUPERHELICAL; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; FLAVONOIDS; FLUOROQUINOLONES; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899051673     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.037     Document Type: Article

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