Detection of key enzymes, free radical reaction products and activated signaling molecules as biomarkers of cell damage induced by benzo[a]pyrene in human keratinocytes

Toxicology in Vitro

Volumn 28, Issue 5, 2014, Pages 875-884

  Bölck, Birgit ^a   Ibrahim, Marwa ^b   Steinritz, Dirk ^c,e   Morguet, Christian ^a   Dühr, Sandra ^a   Suhr, Frank ^a   Lu Hesselmann, Juxian ^d   Bloch, Wilhelm ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^b TANTA UNIVERSITY   (Egypt)

^c BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^d Bundeswehr Institute of Medical Occupational and Environmental Safety   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

Author keywords

Apoptosis; Benzo a pyrene; HaCaT; Keratinocytes; Nitrosative stress; Oxidative stress

Indexed keywords

3 NITROTYROSINE; 8 ISOPROSTANE; BENZO[A]PYRENE; BIOLOGICAL MARKER; CASPASE 3; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUORESCEIN; FREE RADICAL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PROTEIN KINASE B; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SERINE; STRESS ACTIVATED PROTEIN KINASE; THREONINE; 3-NITROTYROSINE; 8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; 8-EPI-PROSTAGLANDIN F2ALPHA; CARCINOGEN; FUSED HETEROCYCLIC RINGS; MITOGEN ACTIVATED PROTEIN KINASE; NOS3 PROTEIN, HUMAN; PROSTAGLANDIN F2 ALPHA; PROTEIN KINASE INHIBITOR; TYROSINE;

APOPTOSIS; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; KERATINOCYTE; NITROSATIVE STRESS; OXIDATIVE STRESS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOXICITY TESTING; ANALOGS AND DERIVATIVES; CELL CULTURE; CELL LINE; DRUG EFFECTS; METABOLISM; TOXICITY;

BENZO(A)PYRENE; BIOLOGICAL MARKERS; CARCINOGENS; CASPASE 3; CELL LINE; CELLS, CULTURED; DINOPROST; FREE RADICALS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; KERATINOCYTES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84899046754     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.03.010     Document Type: Article

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