Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons

Journal of Pharmacology and Experimental Therapeutics

Volumn 314, Issue 2, 2005, Pages 693-702

  Van Grevenynghe, J ^a   Bernard, M ^c   Langouet, S ^a   Le Berre, C ^b   Fest, T ^c   Fardel, O ^a,c  

^a INSERM   (France)

^b ETABLISSEMENT FRANÇAIS DU SANG   (France)

^c RENNES UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 7,8 DIHYDRO 7,8 DIHYDROXYBENZO[A]PYRENE; ALPHA NAPHTHOFLAVONE; AROMATIC HYDROCARBON RECEPTOR; CASPASE; CD34 ANTIGEN; POLYCYCLIC AROMATIC HYDROCARBON;

APOPTOSIS; ARTICLE; BONE MARROW TOXICITY; CARCINOGENESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; ERYTHROID CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA; MACROPHAGE; MEGAKARYOCYTE; METABOLISM; PRIORITY JOURNAL;

EID: 22944471444     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.084780     Document Type: Article

References (40)

1. Ambrose JA and Barua RS (2004) The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol 43:1731-1737.
2. Ball JK (1970) Depressive effect of bone marrow on the yield of 7,12-dimethylbenz[a]anthracene-induced thymic lymphomas. J Natl Cancer Inst 44:439-445.
3. Bartolovic K, Balabanov S, Hartmann U, Komor M, Boehmler AM, Buhring HJ, Mohle R, Hoelzer D, Kanz L, Hofmann WK, et al. (2004) Inhibitory effect of imatinib on normal progenitor cells in vitro. Blood 103:523-529.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 7:248-254.
5. Burchiel SW, Davis DA, Gomez MP, Montano RM, Barton SL, and Seamer LC (1990) Inhibition of lymphocyte activation in splenic and gut-associated lymphoid tissues following oral exposure of mice to 7,12-dimethylbenz[a] anthracene. Toxicol Appl Pharmacol 105:434-442.
6. Buschfort-Papewalis C, Moritz T, Liedert B, and Thomale J (2002) Down-regulation of DNA repair in human CD34(+) progenitor cells corresponds to increased drug sensitivity and apoptotic response. Blood 100:845-853.
7. Chang TK, Gonzalez FJ, and Waxman DJ (1994) Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. Arch Biochem Biophys 311:437-442.
8. Davila DR, Romero DL, and Burchiel SW (1996) Human T cells are highly sensitive to suppression of mitogenesis by polycyclic aromatic hydrocarbons and this effect is differentially reversed by alpha-naphtoflavone. Toxicol Appl Pharmacol 139:333-341.
9. De Flora S, D'Agostini F, Izzotti A, and Balansky R (1991) Prevention by N-acetylcysteine of benzo[a]pyrene clastogenicity and DNA adducts in rats. Mutat Res 250:87-93.
10. Delhalle S, Duvoix A, Schnekenburger M, Morceau F, Dicato M, and Diederich M (2003) An introduction to the molecular mechanisms of apoptosis. Ann NY Acad Sci 1010:1-8.
11. Galvan N, Jaskula-Sztul R, MacWilliams PS, Czuprynski CJ, and Jefcoate CR (2003) Bone marrow cytotoxicity of benzo[a]pyrene is dependent on CYP1B1 but is diminished by Ah receptor-mediated induction of CYP1A1 in liver. Toxicol Appl Pharmacol 193:84-96.
12. Gorman AM, Hirt UA, Zhivotovsky B, Orrenius S, and Ceccatelli S (1999) Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo. J Immunol Methods 226:43-48.
13. Heidel SM, MacWilliams PS, Baird WM, Dashwood WM, Buters JTM, Gonzalaz FJ, Larsen MC, Czuprynski CJ, and Jefcoate CR (2000) Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz(a)anthrancene. Cancer Res 60:3454-3460.
14. Irons RD and Stillman WS (1996) The process of leukemogenesis. Environ Health Perspect 104 (Suppl 6):1239-1246.
15. Izzotti A, Balansky R, Scatolini L, Rovida A, and De Flora S (1995) Inhibition by N-acetylcysteine of carcinogen-DNA adducts in the tracheal epithelium of rats exposed to cigarette smoke. Carcinogenesis 16:669-672.
16. Izzotti A, Rossi GA, Bagnasco M, and De Flora S (1991) Benzo(a)pyrene diolepoxide-DNA adducts in alveolar macrophages of smokers. Carcinogenesis 12:1281-1285.
17. Kalbacova M, Vrbacky M, Drahota Z, and Melkova Z (2003) Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry. Cytometry 52:110-116.
18. Kohler T, Plettig R, Wetzstein W, Schaffer B, Ordemann R, Nagels HO, Ehninger G, and Bornhauser M (1999) Defining optimum conditions for the ex vivo expansion of human umbilical cord blood cells. Influences of progenitor enrichment, interference with feeder layers, early-acting cytokines and agitation of culture vessels. Stem Cells 17:19-24.
19. Landers JP and Bunce NJ (1991) The Ah receptor and the mechanism of dioxin toxicity. Biochem J 276:273-287.
20. Laupeze B, Amiot L, Sparfel L, Le Ferrec E, Fauchet R, and Fardel O (2002) Polycyclic aromatic hydrocarbons affect functional differentiation and maturation of human monocyte-derived dendritic cells. J Immunol 168:2652-2658.
21. Lijinsky W (1991) The formation and occurrence of polynuclear aromatic hydrocarbons associated with food. Mutat Res 259:251-261.
22. Lu YF, Santostefano M, Cunningham BD, Threadgill MD, and Safe S (1995) Identification of 3′-methoxy-4′-nitroflavone as a pure aryl hydrocarbon (Ah) receptor antagonist and evidence for more than one form of the nuclear Ah receptor in MCF-7 human breast cancer cells. Arch Biochem Biophys 316:470-477.
23. Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, and Sherr DH (1999) The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[ a]anthracene-induced pre-B lymphocyte apoptosis. Toxicol Appl Pharmacol 161:10-22.
24. Matikainen T, Perez GI, Jurisicova A, Pru JK, Schlezinger JJ, Ryu HY, Laine J, Sakai T, Korsmeyer SJ, Casper RF, Sherr DH, and Tilly JL (2001) Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet 28:355-360.
25. Melendez-Colon VJ, Luch A, Seidel A, and Baird WM (1999) Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts than apurinic sites. Carcinogenesis 20:1885-1891.
26. Mills PK, Newell GR, Beeson WL, Fraser GE, and Phillips RL (1990) History of cigarette smoking and risk of leukemia and myeloma: results from the Adventist health study. J Natl Cancer Inst 82:1832-1836.
27. Nebert DW, Levitt RC, Jensen NM, Lambert GH, and Felton JS (1977) Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus. Arch Toxicol 39:109-132.
28. Nebert DW, Roe AL, Dieter MZ, Solis WA, Yang Y, and Dalton TP (2000) Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control and apoptosis. Biochem Pharmacol 59:65-85.
29. Ogawa M (1993) Differentiation and proliferation of hematopoietic stem cells. Blood 81:2844-2853.
30. Page TJ, MacWilliams PS, Suresh M, Jefcoate CR, and Czuprynski CJ (2004) 7-12 Dimethylbenz[a]anthracene-induced bone marrow hypocellularity is dependent on signaling through both the TNFR and PKR. Toxicol Appl Pharmacol 198:21-28.
31. Phillips DH (1999) Polycyclic aromatic hydrocarbons in the diet. Mutat Res 443:139-147.
32. Salas VM and Burchiel SW (1998) Apoptosis in Daudi human B cells in response to benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol. Toxicol Appl Pharmacol 151: 367-376.
33. Shimada H, Satake S, Itoh S, Hattori C, Hayashi M, and Ishidate M Jr (1990) Multiple-dosing effects of benzo[a]pyrene in the mouse bone marrow micronucleus test. Mutat Res 234:179-181.
34. Shimada T, Yamazaki H, Foroozesh M, Hopkins NE, Alworth WL, and Guengerich FP (1998) Selectivity of polycyclic inhibitors for human cytochrome P450s 1A1, 1A2 and 1B1. Chem Res Toxicol 11:1048-1056.
35. Solhaug A, Refsnes M, Lag M, Schwarze PE, Husoy T, and Holme JA (2004) Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells. Carcinogenesis 25:809-819.
36. van Grevenynghe J, Rion S, Le Ferrec E, Le Vee M, Amiot L, Fauchet R, and Fardel O (2003) Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages. J Immunol 170:2374-2381.
37. van Grevenynghe J, Sparfel L, Le Vee M, Gilot D, Drenou B, Fauchet R, and Fardel O (2004) Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. Biochem Biophys Res Commun 317:708-716.
38. Whitlock JP Jr (1999) Induction of cytochrome P4501A1. Annu Rev Pharmacol Toxicol 39:103-125.
39. Zedeck MS (1980) Polycyclic aromatic hydrocarbons: a review. J Environ Pathol Toxicol 3:537-567.
40. Zhu H, Li Y, and Trush MA (1995) Characterization of benzo[a]pyrene quinoneinduced toxicity to primary cultured bone marrow stromal cells from DBA/2 mice: potential role of mitochondrial dysfunction. Toxicol Appl Pharmacol 130:108-120.