13F-1, a novel 5-fluorouracil prodrug containing an Asn-Gly-Arg (NO 2) COOCH3 tripeptide, inhibits human colonic carcinoma growth by targeting Aminopeptidase N (APN/CD13)

European Journal of Pharmacology

Volumn 734, Issue 1, 2014, Pages 50-59

  Cui, Shu Xiang ^a   Zhang, Hou Li ^b   Xu, Wen Fang ^c   Qu, Xian Jun ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Tanshan Medical University   (China)

^c SHANDONG UNIVERSITY   (China)

Author keywords

5 Fluorouracil; Aminopeptidase N (APN CD13); Apoptosis; Asparagine glycine arginine (NGR); Colon cancer

Indexed keywords

13F I; ANTINEOPLASTIC AGENT; FLUOROURACIL; MICROSOMAL AMINOPEPTIDASE; UNCLASSIFIED DRUG; 13F-1 COMPOUND; NGR PEPTIDE; OLIGOPEPTIDE; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION; CELL SURFACE; CLONOGENIC ASSAY; COLON CARCINOMA; COLORIMETRY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR PROBE; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOXICITY TESTING; TREATMENT DURATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; CHEMISTRY; COLONIC NEOPLASMS; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIGENS, CD13; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; FEMALE; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MOLECULAR TARGETED THERAPY; OLIGOPEPTIDES; PRODRUGS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84899041264     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.04.001     Document Type: Article

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