The β-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP

Experimental Biology and Medicine

Volumn 239, Issue 4, 2014, Pages 454-464

  Han, Na Ra ^a   Kim, Hyung Min ^a   Jeong, Hyun Ja ^b  

^a Kyung Hee University   (South Korea)

^b Hoseo University   (South Korea)

Author keywords

atopic dermatitis; caspase 1; mast cell; TSLP; Sitosterol

Indexed keywords

ATOPIC DERMATITIS; CASPASE-1; MAST CELL; TSLP; Β-SITOSTEROL;

ANIMALS; CASPASE 1; CELL LINE; CYTOKINES; DERMATITIS, ATOPIC; DOWN-REGULATION; HISTAMINE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; MICE; MICE, INBRED STRAINS; NF-KAPPA B; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; SITOSTEROLS;

EID: 84899014271     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370213520111     Document Type: Article

References (55)

1. Bieber T.Atopic dermatitis.N Engl J Med. 2008;358:1483-94.
2. Bieber T.Atopic dermatitis.Ann Dermatol. 2010;22:125-37.
3. Berroth A,Kühnl J,Kurschat N,Schwarz A,Stäb F,Schwarz T,Wenck H,Fölster-Holst R,Neufang G.Role of fibroblasts in the pathogenesis of atopic dermatitis.J Allergy Clin Immunol. 2013;131:1547-54.
4. Fujiwara R,Sasajima N,Takemura N,Ozawa K,Nagasaka Y,Okubo T,Sahasakul Y,Watanabe J,Sonoyama K.2,4-Dinitrofluorobenzene-induced contact hypersensitivity response in NC/Nga mice fed fructo-oligosaccharide.J Nutr Sci Vitaminol (Tokyo). 2010;56:260-5.
5. Yokozeki H,Ghoreishi M,Takagawa S,Takayama K,Satoh T,Katayama I,Takeda K,Akira S,Nishioka K.Signal transducer and activator of transcription 6 is essential in the induction of contact hypersensitivity.J Exp Med. 2000;191:995-1004.
6. Leung DY,Bieber T.Atopic dermatitis.Lancet. 2003;361:151-60.
7. Vestergaard C,Yoneyama H,Murai M,Nakamura K,Tamaki K,Terashima Y,Imai T,Yoshie O,Irimura T,Mizutani H,Matsushima K.Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions.J Clin Invest. 1999;104:1097-105.
8. Navi D,Saegusa J,Liu FT.Mast cells and immunological skin diseases.Clin Rev Allergy Immunol. 2007;33:144-55.
9. Oiwa M,Satoh T,Watanabe M,Niwa H,Hirai H,Nakamura M,Yokozeki H.CRTH2-dependent, STAT6-independent induction of cedar pollen dermatitis.Clin Exp Allergy. 2008;38:1357-66.
10. Schneider C,Döcke WD,Zollner TM,Röse L.Chronic mouse model of TMA-induced contact hypersensitivity.J Invest Dermatol. 2009;129:899-907.
11. Dumortier A,Durham AD,Di Piazza M,Vauclair S,Koch U,Ferrand G,Ferrero I,Demehri S,Song LL,Farr AG,Leonard WJ,Kopan R,Miele L,Hohl D,Finke D,Radtke F.Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin.PLoS One. 2010;5:e9258-e9258.
12. Henz BM,Maurer M,Lippert U,Worm M,Babina M.Mast cells as initiators of immunity and host defense.Exp Dermatol. 2001;10:1-10.
13. Han NR,Kim HM,Jeong HJ.Thymic stromal lymphopoietin is regulated by the intracellular calcium.Cytokine. 2012;59:215-7.
14. Moon PD,Kim HM.Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-jB pathway in mast cells.Cytokine. 2011;54:239-43.
15. Shiraishi H,Masuoka M,Ohta S,Suzuki S,Arima K,Taniguchi K,Aoki S,Toda S,Yoshimoto T,Inagaki N,Conway SJ,Narisawa Y,Izuhara K.Periostin contributes to the pathogenesis of atopic dermatitis by inducing TSLP production from keratinocytes.Allergol Int. 2012;61:563-72.
16. Wang WL,Li HY,Zhang MS,Gao PS,He SH,Zheng T,Zhu Z,Zhou LF.Thymic stromal lymphopoietin: a promising therapeutic target for allergic diseases.Int Arch Allergy Immunol. 2013;160:18-26.
17. Radika MK,Viswanathan P,Anuradha CV.Nitric oxide mediates the insulin sensitizing effects of β-sitosterol in high fat diet-fed rats.Nitric Oxide. 2013;32:43-53.
18. Gylling H,Miettinen TA.Effects of inhibiting cholesterol absorption and synthesis on cholesterol and lipoprotein metabolism in hypercholesterolemic non-insulin-dependent diabetic men.J Lipid Res. 1996;37:1776-85.
19. Ivorra MD,D'Ocon MP,Paya M,Villar A.Antihyperglycemic and insulinreleasing effects of beta-sitosterol 3-beta-D-glucoside and its aglycone, beta-sitosterol.Arch Int Pharmacodyn Ther. 1988;296:224-31.
20. Baskar AA,Ignacimuthu S,Paulraj GM,Al Numair KS.Chemopreventive potential of b-Sitosterol in experimental colon cancer model - an in vitro and in vivo study.BMC Complement Altern Med. 2010;10:24-33.
21. Bouic PJ.Sterols and sterolins new drugs for the immune system?.Drug Discov Today. 2002;7:775-8.
22. Park SJ,Lee HA,Kim JW,Lee BS,Kim EJ.Platycodon grandiflorus alleviates DNCB-induced atopy-like dermatitis in NC/Nga mice.Indian J Pharmacol. 2012;44:469-74.
23. Mahajan SG,Mehta AA,Mahajan SG,Mehta AA.Suppression of ovalbumin-induced Th2-driven airway inflammation by β-sitosterol in a guinea pig model of asthma.Eur J Pharmacol. 2011;650:458-64.
24. Desai F,Ramanathan M,Fink CS,Wilding GE,Weinstock-Guttman B,Awad AB.Comparison of the immunomodulatory effects of the plant sterol beta-sitosterol to simvastatin in peripheral blood cells from multiple sclerosis patients.Int Immunopharmacol. 2009;9:153-7.
25. Bustos P,Duffau C,Pacheco C,Ulloa N.beta-Sitosterol modulation of monocyte-endothelial cell interaction: a comparison to female hormones.Maturitas. 2008;60:202-8.
26. Glatzer F, Gschwandtner M, Ehling S, Rossbach K, Janik K, Klos A, Bäumer W, Kietzmann M, Werfel T, Gutzmer R. Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor. J Allergy Clin Immunol 2013;132:1358-67.
27. Oh HA,Ryu JG,Cha WS,Kim HM,Jeong HJ.Therapeutic effects of traditional Korean medicine, Jeechool-Whan in allergic rhinitis model.TANG. 2013;2:e9-e9.
28. Jeong HJ,Hong SH,Lee DJ,Park JH,Kim KS,Kim HM.Role of Ca(2+) on TNF-alpha and IL-6 secretion from RBL-2H3 mast cells.Cell Signal. 2002;14:633-9.
29. Yatsuzuka R,Inoue T,Jiang S,Nakano Y,Kamei C.Development of new atopic dermatitis models characterized by not only itching but also inflammatory skin in mice.Eur J Pharmacol. 2007;565:225-31.
30. Han NR,Moon PD,Kim HM,Jeong HJ.Effect of Pyeongwee-San (KMP6) on 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.Life Sci. 2012;90:147-53.
31. Kim JY,Lee IK,Son MW,Kim KH.Effects of orally administered Actinidia arguta (Hardy Kiwi) fruit extract on 2-chloro-1,3,5-trinitrobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice.J Med Food. 2009;12:1004-15.
32. Jinnestål CL, Belfrage E, Bäck O, Schmidtchen A, Sonesson A. Skin barrier impairment correlates with cutaneous Staphylococcus aureus colonization and sensitization to skin-associated microbial antigens in adult patients with atopic dermatitis. Int J Dermatol 2014;53:27-33.
33. Larson RP,Zimmerli SC,Comeau MR,Itano A,Omori M,Iseki M,Hauser C,Ziegler SF.Dibutyl phthalate-induced thymic stromal lymphopoietin is required for Th2 contact hypersensitivity responses.J Immunol. 2010;184:2974-84.
34. Hulse KE,Reefer AJ,Engelhard VH,Patrie JT,Ziegler SF,Chapman MD,Woodfolk JA.Targeting allergen to FcgammaRI reveals a novel T(H)2 regulatory pathway linked to thymic stromal lymphopoietin receptor.J Allergy Clin Immunol. 2010;125:247-56.e1-8.
35. Ito T,Wang YH,Duramad O,Hori T,Delespesse GJ,Watanabe N,Qin FX,Yao Z,Cao W,Liu YJ.TSLP activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.J Exp Med. 2005;202:1213-23.
36. Soumelis V,Reche PA,Kanzler H,Yuan W,Edward G,Homey B,Gilliet M,Ho S,Antonenko S,Lauerma A,Smith K,Gorman D,Zurawski S,Abrams J,Menon S,McClanahan T,de Waal-Malefyt Rd R,Bazan F,Kastelein RA,Liu YJ.Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.Nat Immunol. 2002;3:673-80.
37. Al-Shami A,Spolski R,Kelly J,Keane-Myers A,Leonard WJ.A role for TSLP in the development of inflammation in an asthma model.J Exp Med. 2005;202:829-39.
38. Yoo J,Omori M,Gyarmati D,Zhou B,Aye T,Brewer A,Comeau MR,Campbell DJ,Ziegler SF.Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin.J Exp Med. 2005;202:541-9.
39. Wang YH,Ito T,Wang YH,Homey B,Watanabe N,Martin R,Barnes CJ,McIntyre BW,Gilliet M,Kumar R,Yao Z,Liu YJ.Maintenance and polarization of human TH2 central memory T cells by thymic stromal lymphopoietin-activated dendritic cells.Immunity. 2006;24:827-38.
40. Saenz SA,Taylor BC,Artis D.Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites.Immunol Rev. 2008;226:172-90.
41. Wang YH,Angkasekwinai P,Lu N,Voo KS,Arima K,Hanabuchi S,Hippe A,Corrigan CJ,Dong C,Homey B,Yao Z,Ying S,Huston DP,Liu YJ.IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.J Exp Med. 2007;204:1837-47.
42. Imai Y,Yasuda K,Sakaguchi Y,Haneda T,Mizutani H,Yoshimoto T,Nakanishi K,Yamanishi K.Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice.Proc Natl Acad Sci U S A. 2013;110:13921-6.
43. Wu X,Guo R,Chen P,Wang Q,Cunningham PN.TNF induces caspase-dependent inflammation in renal endothelial cells through a Rho- and myosin light chain kinase-dependent mechanism.Am J Physiol Renal Physiol. 2009;297:F316-26.
44. Yamanaka K,Tanaka M,Tsutsui H,Kupper TS,Asahi K,Okamura H,Nakanishi K,Suzuki M,Kayagaki N,Black RA,Miller DK,Nakashima K,Shimizu M,Mizutani H.Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18.J Immunol. 2000;165:997-1003.
45. Murakami T,Yamanaka K,Tokime K,Kurokawa I,Tsutsui H,Nakanishi K,Mizutani H.Topical suplatast tosilate (IPD) ameliorates Th2 cytokine-mediated dermatitis in caspase-1 transgenic mice by downregulating interleukin-4 and interleukin-5.Br J Dermatol. 2006;155:27-32.
46. McCarthy JV,Ni J,Dixit VM.RIP2 is a novel NF-kappaB activating and cell death-inducing kinase.J Biol Chem. 1998;273:16968-75.
47. Kim MS,Kim WG,Chung HS,Park BW,Ahn KS,Kim JJ,Bae H.Improvement of atopic dermatitis-like skin lesions by Platycodon grandiflorum fermented by Lactobacillus plantarum in NC/Nga mice.Biol Pharm Bull. 2012;35:1222-9.
48. Okuyama K,Wada K,Chihara J,Takayanagi M,Ohno I.Sex-related splenocyte function in a murine model of allergic asthma.Clin Exp Allergy. 2008;38:1212-9.
49. Fujimoto M,Ukichi K,Okamura T,Takada A,Fukushima D,Morimoto M,Yamane GY,Takahashi S.Splenocyte cytokine profile in mouse with oral mucosa-sensitization and oral-tolerization by NiSO(4).Bull Tokyo Dent Coll. 2011;52:85-93.
50. Ackermann L,Harvima IT.Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-alpha and their degranulation is associated with expression of ICAM-1 in the epidermis.Arch Dermatol Res. 1998;290:353-9.
51. Dandekar RD,Khan MM.Regulation of ERK2 phosphorylation by histamine in splenocytes.Immunopharmacol Immunotoxicol. 2011;33:250-8.
52. Ding N,Kunugita N,Ichinose T,Song Y,Yokoyama M,Arashidani K,Yoshida Y.Intratracheal administration of fullerene nanoparticles activates splenic CD11b+ cells.J Hazard Mater. 2011;194:324-30.
53. Rizvi A,Pecaut MJ,Gridley DS.Low-dose gamma-rays and simulated solar particle event protons modify splenocyte gene and cytokine expression patterns.J Radiat Res. 2011;52:701-11.
54. Burks AW,Calderon MA,Casale T,Cox L,Demoly P,Jutel M,Nelson H,Akdis CA.Update on allergy immunotherapy. American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report.J Allergy Clin Immunol. 2013;131:1288-96.e3.
55. Dey M,Ribnicky D,Kurmukov AG,Raskin I.In vitro and in vivo anti-inflammatory activity of a seed preparation containing phenethylisothiocyanate.J Pharmacol Exp Ther. 2006;317:326-33.