Testing for linkage of eye tracking dysfunction and schizophrenia to markers on chromosomes 6, 8, 9, 20, and 22 in families multiply affected with schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 88, Issue 6, 1999, Pages 603-606

  Arolt, Volker ^a   Lencer, Rebekka ^b   Purmann, Sabine ^b   Schürmann, Manfred ^b   Müller Myhsok, Bertram ^c   Krecker, Katja ^b   Schwinger, Eberhard ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME; CHROMOSOME 20; CHROMOSOME 22; CHROMOSOME 6; CHROMOSOME 8; CHROMOSOME 9; EYE TRACKING; GENETIC LINKAGE; HUMAN; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCHIZOPHRENIA;

ALLELES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 6; FAMILY HEALTH; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); MODELS, GENETIC; OCULAR MOTILITY DISORDERS; PENETRANCE; PREVALENCE; PURSUIT, SMOOTH; SCHIZOPHRENIA; STATISTICS, NONPARAMETRIC;

EID: 0033573255     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(19991215)88:6<603::AID-AJMG5>3.0.CO;2-X     Document Type: Article

References (24)

1. Antonarakis SE, Blouin JL, Pulver AE, Wolyniec P, Lasseter VK, Nestadt G, Kasch L, Babb R, Kazazian HH, Dombroski B, Kimberland M, Ott J, Housmann D, Karayiogou M, McLean CJ. 1995. Schizophrenia susceptibility and chromosome 6p24-22 (letter). Nat Genet 11:235-236.
2. Arolt V, Lencer R, Nolte A, Müller-Myhsok B, Purmann S, Schürmann M, Leutelt J, Pinnow M, Schwinger E. 1996a. Eye tracking dysfunction is a putative phenotypic susceptibility marker of schizophrenia and maps to a locus on chromosome 6p in families with multiple occurrence of the disease. Am J Med Genet 67:564-579.
3. Arolt V, Lencer R, Nolte A, Pinnow M, Schwinger E. 1996b. Eye tracking dysfunction in families with multiple cases of schizophrenia. Eur Arch Psychiatr Neurosci 246:175-181.
4. Budowle B, Chakraborty R, Giusti AM, Eisenberg AJ, Allen RC. 1991. Analysis of the VNTR locus D1S80 by the PCR followed by high resolution PAGE. Am J Hum Genet 48:137-144.
5. Coon H, Holik J, Hoff M, Reinherr F, Wender P, Myles-Worsley M, Waldo M, Freedman R, Byerley W. 1994. Analysis of chromosome 22 markers in nine schizophrenia pedigrees. Am J Med Genet 54:72-79.
6. Cottingham RW, Idury RM, Schaffer AA. 1993. Faster sequential genetic linkage computations. Am J Hum Genet 53:252-263.
7. Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulus M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonhard S, Byerley W. 1997. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci USA 94:587-592.
8. Gurling H, Kalsi G, Andrew HSC, Green M, Butler R, Read T, Murphy P, Curtis D, Sharma T, Petursson H, Brynjolfsson J. 1995. Schizophrenia susceptibility and chromosome 6p24-22 (letter). Nat Genet 11:234-235.
9. Kendler KS, Lieberman JA, Walsh D. 1989. The structured interview for schizotypy (SIS): a preliminary report. Schizophr Bull 15:559-571.
10. Kendler KS, McLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J, Walsh D, Straub RE. 1996. Evidence of a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high density schizophrenia families. Am J Psychiatry 153:1534-1540.
11. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
12. Maziade M, Bissonette L, Rouillard E, Martinez M, Turgeon M Charron L, Pouliot V, Boutin P, Cliche D, Dion C, Fournier JP, Garneau Y, Lavallee JC, Montgrain N, Nicle L, Pires A, Ponton AM, Potvin A, Wallot H, Roy MA, le Group IREP, Merette C. 1997. 6p24-22 Region and major psychoses in Eastern Quebec population. Am J Med Genet 74:311-318.
13. Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F, Arolt V, Blackwood D, Liu X, Sjögren B, Aschauer HN, Hwu H-G, Jang K, Livesley WJ, Kennedy JL, Zoega T, Ivarsson O, Bui M-T, Yu M-H, Havsteen B, Commenges D, Weissenbach J, Schwinger E, Gottesman II, Pakstis AJ, Wetterberg L, Kidd KK, Helgason T. 1995. An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 11:321-324.
14. Mowry BJ, Nancarrow DJ, Lennon DP, Sandkuijl LA, Crowe RR, Silverman JM, Mohs RC, Siever LJ, Endicott J, Sharpe L, Walters MK, Hayward NK, Levinson DF. 1995. Schizophrenia susceptibility and chromosome 6p24-22 (letter). Nat Genet 11:233-234.
15. Peltonen L. 1995. All out for chromosome six. Nature 378:665-666.
16. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, Antonarakis S, Housman D, Kazazian HH, Meyers D, Ott J, Lamacz M, Liang KY, Hanfelt J, Ullrich G, Dimarchi N, Ramu E, McHugh PM, Adler L, Thomas M, Carpenter WT, Manschreck T, Gordon CT, Kimberland M, Babb R, Puck J, Childs B. 1994. Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: part 1. Am J Med Genet 54:36-43.
17. Pulver AE, Lasseter VK, Kasch L, Wolyniec P, Nestadt G, Blouin J-L, Kimberland M, Babb R, Vourlis S, Chen H, Lalioti M, Morris MA, Karayiorgou M, Ott J, Meyers D, Antonorakis SE, Housman D, Kazazian HH. 1995. Schizophrenia: a genome scan targets chromosomes 3p and 8p as potential sites of susceptibility genes. Am J Med Genet 60: 252-260.
18. Riley BP, Mogudi-Carter M, Rajagopalan S, Jenkins T, Williamson R. 1995. No evidence for linkage of schizophrenia to the short arm of chromosome 6 in a sample of southern African Bantu-speaking families. Psychiatr Genet 5(suppl):34 (abstr).
19. Sasaki T, Basset AS, Honer WG, King N, Goitan K, Winter H, Basile V, Macciardi FM, Kennedy JL. 1995. Evaluation of markers 6p21-23 in Eastern Canadian schizophrenic families. Am J Hum Genet 57(suppl): 1165 (abstr).
20. Schaffer AA, Gupta SK, Shiram K, Cottingham RW. 1994. Avoiding recomputation in genetic linkage analysis. Hum Hered 44:225-273.
21. Schizophrenia Linkage Collaboration Group for Chromosomes 3, 6 and 8. 1996. Additional support for schizophrenia linkage on chromosomes 6 and 8: a multicenter study. Am J Med Genet 67:580-594.
22. Schwab SG, Albus M, Hallmayer J, Hönig S, Borrmann M, Lichtermann D, Ebstein RP, Ackenheil M, Lerer B, Risch N, Maier W, Wildenauer DR. 1995. Evaluation of a susceptibility gene for schizophrenia on chromosome 6p by multipoint affected sib-pair linkage analysis. Nat Genet 11:325-327.
23. Straub RE, McLean CJ, O'Neill FE, Burke J, Murphy B, Duke F, Shinkwin R, Webb BT, Zhang J, Walsh D, Kendler KS. 1995. A potential susceptibility locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity. Nat Genet 11:284-293.
24. Weber JL, May PE. 1989. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am J Hum Genet 44:388-396.