Binding-induced fluorescence of serotonin transporter ligands: A spectroscopic and structural study of 4-(4-(Dimethylamino)phenyl)-1- methylpyridinium (APP+) and APP+ analogues

ACS Chemical Neuroscience

Volumn 5, Issue 4, 2014, Pages 296-304

  Wilson, James N ^a   Ladefoged, Lucy Kate ^b   Babinchak, W Michael ^a   Schiøtt, Birgit ^b  

^a Department of Biology   (United States)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

fluorescence; induced fit docking; LeuT; quantum polarized ligand docking; Serotonin; SERT

Indexed keywords

1 BUTYL 4 [4 (1 DIMETHYLAMINO)PHENYL] PYRIDINIUM BROMIDE; 1 METHYL 4 [4 (1 PIPERIDINYL)PHENYL] PYRIDINIUM; 4 [4 (DIMETHYLAMINO)PHENYL] 1 METHYLPYRIDINIUM; LIGAND; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; 4-(4-(DIMETHYLAMINO)PHENYL)-1-METHYLPYRIDINIUM; ANILINE DERIVATIVE; PROTEIN BINDING; PYRIDINIUM DERIVATIVE; SEROTONIN;

ARTICLE; BINDING SITE; CONFORMATION; CONTROLLED STUDY; FLUORESCENCE SPECTROSCOPY; HUMAN; HUMAN CELL; LIGAND BINDING; MICROENVIRONMENT; MOLECULAR DOCKING; PRIORITY JOURNAL; VISCOSITY; CHEMISTRY; COMPARATIVE STUDY; COMPUTER SIMULATION; PROCEDURES; SPECTROFLUOROMETRY; ULTRASTRUCTURE;

ANILINE COMPOUNDS; BINDING SITES; COMPUTER SIMULATION; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PYRIDINIUM COMPOUNDS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SPECTROMETRY, FLUORESCENCE;

EID: 84898983109     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400230x     Document Type: Article

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