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Volumn 4, Issue 5, 2013, Pages 858-869

APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter

Author keywords

acute mouse brain slice; APP+; catecholamine neurons; fluorescent false neurotransmitters; neuronal imaging agent; two photon microscopy

Indexed keywords

4 (DIMETHYLAMINO)PHENYL 1 METHYLPYRIDINIUM; DOPAMINE TRANSPORTER; FLUORESCENT DYE; NORADRENALIN TRANSPORTER; UNCLASSIFIED DRUG;

EID: 84877798003     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400038u     Document Type: Article
Times cited : (34)

References (55)
  • 1
    • 77952544119 scopus 로고    scopus 로고
    • Cytological staining methods
    • In (Windhorst, U. and Johansson, H. Eds.), pp, Springer-Verlag, Berlin & Heidelberg
    • Banks, R. W. (1999) Cytological staining methods. In Modern Techniques in Neuroscience Research (Windhorst, U. and Johansson, H., Eds.), pp 1-26, Springer-Verlag, Berlin & Heidelberg.
    • (1999) Modern Techniques in Neuroscience Research , pp. 1-26
    • Banks, R.W.1
  • 2
    • 18744409106 scopus 로고    scopus 로고
    • Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo
    • Nimmerjahn, A., Kirchhoff, F., Kerr, J. N., and Helmchen, F. (2004) Sulforhodamine 101 as a specific marker of astroglia in the neocortex in vivo Nat. Methods 1, 31-37
    • (2004) Nat. Methods , vol.1 , pp. 31-37
    • Nimmerjahn, A.1    Kirchhoff, F.2    Kerr, J.N.3    Helmchen, F.4
  • 3
    • 65349182363 scopus 로고    scopus 로고
    • Diversity-oriented fluorescence library approach for the discovery of sensors and probes
    • Lee, J.-S., Kim, Y. K., Vendrell, M., and Chang, Y.-T. (2009) Diversity-oriented fluorescence library approach for the discovery of sensors and probes Mol. BioSyst. 5, 411-421
    • (2009) Mol. BioSyst. , vol.5 , pp. 411-421
    • Lee, J.-S.1    Kim, Y.K.2    Vendrell, M.3    Chang, Y.-T.4
  • 6
    • 0019333905 scopus 로고
    • New calcium indicators and buffers with high selectivity against magnesium and protons: Design, synthesis, and properties of prototype structures
    • Tsien, R. Y. (1980) New calcium indicators and buffers with high selectivity against magnesium and protons: Design, synthesis, and properties of prototype structures Biochemistry 19, 2396-2404
    • (1980) Biochemistry , vol.19 , pp. 2396-2404
    • Tsien, R.Y.1
  • 7
    • 78650951809 scopus 로고    scopus 로고
    • Imaging Voltage in Neurons
    • Peterka, D., Takahashi, H., and Yuste, R. (2011) Imaging Voltage in Neurons Neuron 69, 9-21
    • (2011) Neuron , vol.69 , pp. 9-21
    • Peterka, D.1    Takahashi, H.2    Yuste, R.3
  • 8
    • 34548833278 scopus 로고    scopus 로고
    • Imaging synaptic vesicle exocytosis and endocytosis with FM dyes
    • Gaffield, M. A. and Betz, W. J. (2006) Imaging synaptic vesicle exocytosis and endocytosis with FM dyes Nat. Protoc. 1, 2916-2921
    • (2006) Nat. Protoc. , vol.1 , pp. 2916-2921
    • Gaffield, M.A.1    Betz, W.J.2
  • 9
    • 84877835853 scopus 로고    scopus 로고
    • Visualizing Neurotransmitter Secretion at Individual Synapses
    • DOI: 10.1021/cn4000956
    • Sames, D., Dunn, M., Krapowicz, R. J., Jr., and Sulzer, D. (2013) Visualizing Neurotransmitter Secretion at Individual Synapses. ACS Chem. Neurosci. DOI: 10.1021/cn4000956.
    • (2013) ACS Chem. Neurosci.
    • Sames, D.1    Dunn, M.2    Krapowicz, Jr.R.J.3    Sulzer, D.4
  • 12
    • 2642519680 scopus 로고    scopus 로고
    • Dopamine, learning and motivation
    • Wise, R. A. (2004) Dopamine, learning and motivation Nat. Rev. Neurosci. 5, 483-494
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 483-494
    • Wise, R.A.1
  • 15
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N -methyl-4-phenyl-1,2,3,6- tetrahydropyridine: Uptake of metabolite N- methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch, J. A., D'Amato, R. J., Strittmatter, S. M., and Snyder, S. H. (1985) Parkinsonism-inducing neurotoxin, N -methyl-4-phenyl-1,2,3,6- tetrahydropyridine: Uptake of metabolite N- methyl-4-phenylpyridine by dopamine neurons explains selective toxicity Proc. Natl. Acad. Sci. U.S.A. 82, 2173-2177
    • (1985) Proc. Natl. Acad. Sci. U.S.A. , vol.82 , pp. 2173-2177
    • Javitch, J.A.1    D'Amato, R.J.2    Strittmatter, S.M.3    Snyder, S.H.4
  • 16
    • 0030877835 scopus 로고    scopus 로고
    • Dopamine transporter is required for in vivo MPTP neurotoxicity: Evidence from mice lacking the transporter
    • Gainetdinov, R. R., Fumagalli, F., Jones, S. R., and Caron, M. G. (1997) Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter J. Neurochem. 69, 1322-1325
    • (1997) J. Neurochem. , vol.69 , pp. 1322-1325
    • Gainetdinov, R.R.1    Fumagalli, F.2    Jones, S.R.3    Caron, M.G.4
  • 17
    • 0028577297 scopus 로고
    • Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4- phenylpyridinium
    • Buck, K. J. and Amara, S. G. (1994) Chimeric dopamine-norepinephrine transporters delineate structural domains influencing selectivity for catecholamines and 1-methyl-4-phenylpyridinium Proc. Natl. Acad. Sci. U.S.A. 91, 12584-12588
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 12584-12588
    • Buck, K.J.1    Amara, S.G.2
  • 18
    • 0028914666 scopus 로고
    • Biogenic Amine Flux Mediated by Cloned Transporters Stably Expressed in Cultured Cell Lines: Amphetamine Specificity for Inhibition and Efflux
    • Wall, S. C., Gu, H., and Rudnick, G. (1995) Biogenic Amine Flux Mediated by Cloned Transporters Stably Expressed in Cultured Cell Lines: Amphetamine Specificity for Inhibition and Efflux Mol. Pharmacol. 47, 544-550
    • (1995) Mol. Pharmacol. , vol.47 , pp. 544-550
    • Wall, S.C.1    Gu, H.2    Rudnick, G.3
  • 19
    • 0029583203 scopus 로고
    • The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters
    • Yelin, R. and Schuldiner, S. (1995) The pharmacological profile of the vesicular monoamine transporter resembles that of multidrug transporters FEBS Lett. 337, 201-207
    • (1995) FEBS Lett. , vol.337 , pp. 201-207
    • Yelin, R.1    Schuldiner, S.2
  • 20
    • 0034108225 scopus 로고    scopus 로고
    • Inhibition of Brain Vesicular Monoamine Transporter (VMAT2) Enhances 1-Methyl-4-phenylpyridinium Neurotoxicity in Vivo in Rat Striata
    • Staal, R. G. and Sonsalla, P. K. (2000) Inhibition of Brain Vesicular Monoamine Transporter (VMAT2) Enhances 1-Methyl-4-phenylpyridinium Neurotoxicity In Vivo in Rat Striata J. Pharmacol. Exp. Ther. 293, 336-342
    • (2000) J. Pharmacol. Exp. Ther. , vol.293 , pp. 336-342
    • Staal, R.G.1    Sonsalla, P.K.2
  • 22
    • 0023893927 scopus 로고
    • Mechanism of the Neurotoxicity of 1-Methyl-4-phenylpyridinium (MPP+), the Toxic Bioactivation Product of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
    • Singer, T. P., Ramsay, R. R., McKeown, K., Trevor, A., and Castagnoli, N. E. (1988) Mechanism of the Neurotoxicity of 1-Methyl-4-phenylpyridinium (MPP+), the Toxic Bioactivation Product of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Toxicology 49, 17-23
    • (1988) Toxicology , vol.49 , pp. 17-23
    • Singer, T.P.1    Ramsay, R.R.2    McKeown, K.3    Trevor, A.4    Castagnoli, N.E.5
  • 23
    • 0022352725 scopus 로고
    • Evidence for the release of 1-methyl-4-phenylpyridinium (MPP+) from rat striatal neurons in vitro
    • Keller, H. H. and da Prada, M. (1985) Evidence for the release of 1-methyl-4-phenylpyridinium (MPP+) from rat striatal neurons in vitro Eur. J. Pharmacol. 119, 247-250
    • (1985) Eur. J. Pharmacol. , vol.119 , pp. 247-250
    • Keller, H.H.1    Da Prada, M.2
  • 24
    • 0037984383 scopus 로고    scopus 로고
    • Binding and Transport in Norepinephrine Transporters
    • Schwartz, J. W., Blakely, R. D., and DeFelice, L. J. (2003) Binding and Transport in Norepinephrine Transporters J. Biol. Chem. 278, 9768-9777
    • (2003) J. Biol. Chem. , vol.278 , pp. 9768-9777
    • Schwartz, J.W.1    Blakely, R.D.2    Defelice, L.J.3
  • 25
    • 21444458653 scopus 로고    scopus 로고
    • Substrate Binding Stoichiometry and Kinetics of the Norepinephrine Transporter
    • Schwartz, J. W., Novarino, G., Piston, D. W., and DeFelice, L. J. (2005) Substrate Binding Stoichiometry and Kinetics of the Norepinephrine Transporter J. Biol. Chem. 280, 19177-19184
    • (2005) J. Biol. Chem. , vol.280 , pp. 19177-19184
    • Schwartz, J.W.1    Novarino, G.2    Piston, D.W.3    Defelice, L.J.4
  • 27
    • 0008845637 scopus 로고
    • Antibacterial properties of some N-substituted pyridine derivatives
    • Kolomoitsev, P. R. (1962) Antibacterial properties of some N-substituted pyridine derivatives Mikrobiol. Z. 24, 23-27
    • (1962) Mikrobiol. Z. , vol.24 , pp. 23-27
    • Kolomoitsev, P.R.1
  • 28
    • 0004118849 scopus 로고
    • Structure-colour relationships of some new N -arylpyridinium hemicyanine dyes
    • Hutchings, M. G. (1984) Structure-colour relationships of some new N -arylpyridinium hemicyanine dyes Tetrahedron 40, 2061-2068
    • (1984) Tetrahedron , vol.40 , pp. 2061-2068
    • Hutchings, M.G.1
  • 29
    • 33751391755 scopus 로고
    • Twisted Internal Charge Transfer in (Aminophenyl)pyridinium
    • Fromherz, P. and Heilemann, A. (1992) Twisted Internal Charge Transfer in (Aminophenyl)pyridinium J. Phys. Chem. 96, 6864-6866
    • (1992) J. Phys. Chem. , vol.96 , pp. 6864-6866
    • Fromherz, P.1    Heilemann, A.2
  • 30
    • 0016883750 scopus 로고
    • Dimethylaminostyrylmethylpyridiniumiodine (daspmi) as a fluorescent probe for mitochondria in situ
    • Bereiter-Hahn, J. (1976) Dimethylaminostyrylmethylpyridiniumiodine (daspmi) as a fluorescent probe for mitochondria in situ Biochim. Biophys. Acta 423, 1-14
    • (1976) Biochim. Biophys. Acta , vol.423 , pp. 1-14
    • Bereiter-Hahn, J.1
  • 31
    • 0026536634 scopus 로고
    • Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals
    • Betz, W. J., Mao, F., and Bewick, G. S. (1992) Activity-dependent fluorescent staining and destaining of living vertebrate motor nerve terminals J. Neurosci. 12, 363-375
    • (1992) J. Neurosci. , vol.12 , pp. 363-375
    • Betz, W.J.1    Mao, F.2    Bewick, G.S.3
  • 34
    • 77249149995 scopus 로고    scopus 로고
    • Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate
    • Parker, L. K., Shanks, J. A., Kennard, J. A., and Brain, K. L. (2010) Dynamic monitoring of NET activity in mature murine sympathetic terminals using a fluorescent substrate Br. J. Pharmacol. 159, 797-807
    • (2010) Br. J. Pharmacol. , vol.159 , pp. 797-807
    • Parker, L.K.1    Shanks, J.A.2    Kennard, J.A.3    Brain, K.L.4
  • 35
    • 39849100667 scopus 로고    scopus 로고
    • Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity
    • Jørgensen, S., Nielson, E. Ø., Peters, D., and Dyhring, T. (2008) Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity J. Neurosci. Methods 169, 168-176
    • (2008) J. Neurosci. Methods , vol.169 , pp. 168-176
    • Jørgensen, S.1    Nielson E.Ø2    Peters, D.3    Dyhring, T.4
  • 36
    • 84864073534 scopus 로고    scopus 로고
    • A fluorescent-based assay for live cell, spatially resolved assessment of vesicular monoamine transporter 2-mediated neurotransmitter transport
    • Bernstein, A. I., Stout, K. A., and Miller, G. W. (2012) A fluorescent-based assay for live cell, spatially resolved assessment of vesicular monoamine transporter 2-mediated neurotransmitter transport J. Neurosci. Methods 209, 357-366
    • (2012) J. Neurosci. Methods , vol.209 , pp. 357-366
    • Bernstein, A.I.1    Stout, K.A.2    Miller, G.W.3
  • 37
    • 84862875186 scopus 로고    scopus 로고
    • Single Molecule Analysis of Serotonin Transporter Regulation Using Antagonist-Conjugated Quantum Dots Reveals Restricted, p38 MAPK-Dependent Mobilization Underlying Uptake Activation
    • Chang, J. C., Tomlinson, I. D., Warnement, M. R., Ustione, A., Carneiro, A. M., Piston, D. W., Blakely, R. D., and Rosenthal, S. J. (2012) Single Molecule Analysis of Serotonin Transporter Regulation Using Antagonist- Conjugated Quantum Dots Reveals Restricted, p38 MAPK-Dependent Mobilization Underlying Uptake Activation J. Neurosci. 32, 8919-8929
    • (2012) J. Neurosci. , vol.32 , pp. 8919-8929
    • Chang, J.C.1    Tomlinson, I.D.2    Warnement, M.R.3    Ustione, A.4    Carneiro, A.M.5    Piston, D.W.6    Blakely, R.D.7    Rosenthal, S.J.8
  • 38
    • 84872574500 scopus 로고    scopus 로고
    • Serotonin Uptake is Largely Mediated by Platelets versus Lymphocytes in Peripheral Blood Cells
    • Biekmann, B. S., Tomlinson, I. D., Rosenthal, S. J., and Andrews, A. M. (2012) Serotonin Uptake is Largely Mediated by Platelets versus Lymphocytes in Peripheral Blood Cells ACS Chem. Neurosci. 4, 161-170
    • (2012) ACS Chem. Neurosci. , vol.4 , pp. 161-170
    • Biekmann, B.S.1    Tomlinson, I.D.2    Rosenthal, S.J.3    Andrews, A.M.4
  • 39
    • 0036067524 scopus 로고    scopus 로고
    • Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development
    • Matsushita, N., Okada, H., Yasoshima, Y., Takahashi, K., Kazutoshi, K., and Kobayashi, K. (2002) Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development J. Neurochem. 82, 295-304
    • (2002) J. Neurochem. , vol.82 , pp. 295-304
    • Matsushita, N.1    Okada, H.2    Yasoshima, Y.3    Takahashi, K.4    Kazutoshi, K.5    Kobayashi, K.6
  • 40
    • 0018765159 scopus 로고
    • Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness
    • Borgden, R. N., Heel, R. C., Speight, T. M., and Avery, G. S. (1979) Nomifensine: A review of its pharmacological properties and therapeutic efficacy in depressive illness Drugs 18, 1-24
    • (1979) Drugs , vol.18 , pp. 1-24
    • Borgden, R.N.1    Heel, R.C.2    Speight, T.M.3    Avery, G.S.4
  • 41
    • 9244249202 scopus 로고    scopus 로고
    • Development of the Norepinephrine Transporter in the Rat CNS
    • Sanders, J. D., Happe, H. K., Bylund, D. B., and Murrin, L. C. (2005) Development of the Norepinephrine Transporter in the Rat CNS Neuroscience 130, 107-117
    • (2005) Neuroscience , vol.130 , pp. 107-117
    • Sanders, J.D.1    Happe, H.K.2    Bylund, D.B.3    Murrin, L.C.4
  • 42
    • 33947117309 scopus 로고    scopus 로고
    • Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: Implications for differential drug effects on juveniles and adults
    • Murrin, L. C., Sanders, J. D., and Bylund, D. B. (2007) Comparison of the maturation of the adrenergic and serotonergic neurotransmitter systems in the brain: Implications for differential drug effects on juveniles and adults Biochem. Pharmacol. 73, 1225-1236
    • (2007) Biochem. Pharmacol. , vol.73 , pp. 1225-1236
    • Murrin, L.C.1    Sanders, J.D.2    Bylund, D.B.3
  • 44
    • 80054759784 scopus 로고    scopus 로고
    • Imaging presynaptic exocytosis in corticostriatal slices
    • Wong, M. Y., Sulzer, D., and Bamford, N. S. (2011) Imaging presynaptic exocytosis in corticostriatal slices Methods Mol. Biol. 793, 363-376
    • (2011) Methods Mol. Biol. , vol.793 , pp. 363-376
    • Wong, M.Y.1    Sulzer, D.2    Bamford, N.S.3
  • 46
    • 0029898811 scopus 로고    scopus 로고
    • Ultrastructural Localization of the Vesicular MonoamineTransporter-2 in Midbrain Dopaminergic Neurons: Potential Sites for Somatodendritic Storage and Release of Dopamine
    • Nirenberg, M. J., Chan, J., Liu, Y., Edwards, R. H., and Pickel, V. M. (1996) Ultrastructural Localization of the Vesicular MonoamineTransporter-2 in Midbrain Dopaminergic Neurons: Potential Sites for Somatodendritic Storage and Release of Dopamine J. Neurosci. 16, 4135-4145
    • (1996) J. Neurosci. , vol.16 , pp. 4135-4145
    • Nirenberg, M.J.1    Chan, J.2    Liu, Y.3    Edwards, R.H.4    Pickel, V.M.5
  • 47
    • 0030943452 scopus 로고    scopus 로고
    • Vesicular monoamine transporter-2: Immunogold localization in striatal axons and terminals
    • Nirenberg, M. J., Chan, J., Liu, Y., Edwards, R. H., and Pickel, V. M. (1997) Vesicular monoamine transporter-2: immunogold localization in striatal axons and terminals Synapse 26, 194-198
    • (1997) Synapse , vol.26 , pp. 194-198
    • Nirenberg, M.J.1    Chan, J.2    Liu, Y.3    Edwards, R.H.4    Pickel, V.M.5
  • 48
    • 41949089632 scopus 로고    scopus 로고
    • Expression and function of the rat vesicular monoamine transporter 2
    • Adam, Y., Edwards, R. H., and Schuldiner, S. (2008) Expression and function of the rat vesicular monoamine transporter 2 Am. J. Physiol.: Cell Physiol. 294, C1004-C1011
    • (2008) Am. J. Physiol.: Cell Physiol. , vol.294
    • Adam, Y.1    Edwards, R.H.2    Schuldiner, S.3
  • 49
    • 76049108670 scopus 로고    scopus 로고
    • FM dyes enter via a store-operated calcium channel and modify calcium signaling of cultured astrocytes
    • Li, D., Hérault, K., Oheim, M., and Ropert, N. (2009) FM dyes enter via a store-operated calcium channel and modify calcium signaling of cultured astrocytes Proc. Natl. Acad. Sci. U.S.A. 106, 21960-21965
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 21960-21965
    • Li, D.1    Hérault, K.2    Oheim, M.3    Ropert, N.4
  • 51
    • 78649598223 scopus 로고    scopus 로고
    • Selective Transport of Monoamine Neurotransmitters by Human Plasma Membrane Monoamine Transporter and Organic Cation Transporter 3
    • Duan, H. and Wang, J. (2010) Selective Transport of Monoamine Neurotransmitters by Human Plasma Membrane Monoamine Transporter and Organic Cation Transporter 3 J Pharmacol. Exp. Ther. 335, 743-753
    • (2010) J Pharmacol. Exp. Ther. , vol.335 , pp. 743-753
    • Duan, H.1    Wang, J.2
  • 52
    • 84869233192 scopus 로고    scopus 로고
    • Visualization of implanted GL261 glioma cells in living mouse brain slices using fluorescent 4-(4-(dimethylamino)-styryl)- N -methylpyridinium iodide (ASP+)
    • Kucheryavykh, L. Y., Kucheryavykh, Y. V., Rolón-Reyes, K., Skatchkov, S. N., Eaton, M. J., Cubano, L. A., and Inyushin, M. (2012) Visualization of implanted GL261 glioma cells in living mouse brain slices using fluorescent 4-(4-(dimethylamino)-styryl)- N -methylpyridinium iodide (ASP+) Biotechniques 53, 305-309
    • (2012) Biotechniques , vol.53 , pp. 305-309
    • Kucheryavykh, L.Y.1    Kucheryavykh, Y.V.2    Rolón-Reyes, K.3    Skatchkov, S.N.4    Eaton, M.J.5    Cubano, L.A.6    Inyushin, M.7
  • 53
    • 12644267623 scopus 로고
    • Amezinium: A novel pattern of effects on the sympathetic nervous system
    • Starke, K. (1983) Amezinium: A novel pattern of effects on the sympathetic nervous system Trends. Pharmacol. Sci. 4, 269-272
    • (1983) Trends. Pharmacol. Sci. , vol.4 , pp. 269-272
    • Starke, K.1
  • 54
    • 56049092327 scopus 로고    scopus 로고
    • How DASPMI reveals mitochondrial membrane potential: Fluorescence decay kinetics and steady-state anisotropy in living cells
    • Ramadass, R. and Bereiter-Hahn, J. (2008) How DASPMI reveals mitochondrial membrane potential: fluorescence decay kinetics and steady-state anisotropy in living cells Biophys. J. 95, 4068-4076
    • (2008) Biophys. J. , vol.95 , pp. 4068-4076
    • Ramadass, R.1    Bereiter-Hahn, J.2
  • 55
    • 0027418205 scopus 로고
    • Measurement of co-localization of objects in dual-colour confocal images
    • Manders, E. M. M., Verbeek, F. J., and Aten, J. A. (1993) Measurement of co-localization of objects in dual-colour confocal images J. Microsc. 169, 375-382
    • (1993) J. Microsc. , vol.169 , pp. 375-382
    • Manders, E.M.M.1    Verbeek, F.J.2    Aten, J.A.3


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