Hydroxycarbamide decreases sickle reticulocyte adhesion to resting endothelium by inhibiting endothelial lutheran/ basal cell adhesion molecule (Lu/BCAM) through phosphodiesterase 4A activation

Journal of Biological Chemistry

Volumn 289, Issue 16, 2014, Pages 11512-11521

  Chaar, Vicky ^a,b,c   Laurance, Sandrine ^a,b   Lapoumeroulie, Claudine ^a,b,c   Cochet, Sylvie ^a,b,c   De Grandis, Maria ^a,b,c   Colin, Yves ^a,b,c   Elion, Jacques ^a,b,c,d   Le Van Kim, Caroline ^a,b,c   El Nemer, Wassim ^a,b,c  

^a INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Laboratoire d'Excellence GR Ex   (France)

^d HÔPITAL ROBERT DEBRÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION; ENDOTHELIAL CELLS;

BASAL CELLS; INTEGRINS; PHOSPHODIESTERASES; SICKLE CELL DISEASE; VASCULAR ENDOTHELIUM;

ESTERS;

CYCLIC AMP; HYDROXYUREA; LUTHERAN BASAL CELL ADHESION MOLECULE; MEMBRANE PROTEIN; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV A; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4;

ARTICLE; BONE MARROW; CELL ADHESION; CELL TRANSFORMATION; CONTROLLED STUDY; DRUG EXPOSURE; DRUG MECHANISM; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG ALVEOLUS CELL; METABOLIC INHIBITION; MICROVASCULAR ENDOTHELIAL CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RETICULOCYTE; SICKLE CELL ANEMIA; SIGNAL TRANSDUCTION; UPREGULATION;

ADHESION; BLOOD; CELL SIGNALING; ENDOTHELIAL CELL; HYDROXYCARBAMIDE; LU/BCAM; PROTEIN PHOSPHORYLATION; SICKLE CELL DISEASE;

ANEMIA, SICKLE CELL; ANTISICKLING AGENTS; CELL ADHESION; CELL ADHESION MOLECULES; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROXYUREA; K562 CELLS; LUTHERAN BLOOD-GROUP SYSTEM; PHOSPHORYLATION; RETICULOCYTES; SECOND MESSENGER SYSTEMS; UP-REGULATION;

EID: 84898957336     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.506121     Document Type: Article

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