Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo

Blood

Volumn 110, Issue 7, 2007, Pages 2708-2717

  Zennadi, Rahima ^a   Moeller, Benjamin J ^b   Whalen, Erin J ^b   Batchvarova, Milena ^a   Xu, Ke ^a   Shan, Siqing ^b   Delahunty, Martha ^a   Dewhirst, Mark W ^b   Telen, Marilyn J ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; GLYCOPROTEIN; LW GLYCOPROTEIN; PROPRANOLOL; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; CAPILLARY ENDOTHELIUM; CONTROLLED STUDY; ENDOTHELIUM CELL; ERYTHROCYTE ADHESIVENESS; ERYTHROCYTE KINETICS; FEMALE; IN VITRO STUDY; LEUKOCYTE ADHERENCE; MICROVASCULATURE; MOUSE; NONHUMAN; NUDE MOUSE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SICKLE CELL;

ANEMIA, SICKLE CELL; ANIMALS; CELL ADHESION; CELL ADHESION MOLECULES; CELL SURVIVAL; CELLS, CULTURED; ENDOTHELIUM; EPINEPHRINE; ERYTHROCYTES; HUMANS; LEUKOCYTES; MICE; MICE, NUDE; RECEPTORS, ADRENERGIC, BETA-2;

EID: 34948850854     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-11-056101     Document Type: Article

References (47)

1. Hebbel RP, Yamada O, Moldow CF, Jacob HS, White JG, Eaton JW. Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease. J Clin Invest. 1980;65:154-160.
2. Mohandas N, Evans E. Sickle erythrocyte adherence to vascular endothelium. Morphologic correlates and the requirement for divalent cations and collagen-binding plasma proteins. J Clin Invest. 1985;76:1605-1612.
3. Kaul DK, Fabry ME, Nagel RL. Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications. Proc Natl Acad Sci U S A. 1989;86:3356-3360.
4. Gil KM, Carson JW, Porter LS, Scipio C, Bediako SM, Orringer E. Daily mood and stress predict pain, health care use, and work activity in African American adults with sickle-cell disease. Health Psychol. 2004;23:267-274.
5. Thomas VJ, Hambleton I, Serjeant G. Psychological distress and coping in sickle cell disease: comparison of British and Jamaican attitudes. Ethn Health. 2001;6:129-136.
6. Das SK, Hinds JE, Hardy RE, Collins JC, Mukherjee S. Effects of physical stress on peroxide scavengers in normal and sickle cell trait erythrocytes. Free Radic Biol Med. 1993;14:139-147.
7. Baciu I, Ivanof L, Pavel T, Marina C, Zirbo M, Zdrenghea C. Erythropoietin binding to the red cell membranes. Physiologie. 1985;22:227-231.
8. Hausdorff WP, Bouvier M, O'Dowd BF, Irons GP, Caron MG, Lefkowitz JR. Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. J Biol Chem. 1989;264:12657-61265.
9. + dynamics, contractility, or phospholamban phosphorylation. J Biol Chem. 1994;269:151-156.
10. + influx and cAMP-mediated signaling pathways. Am J Physiol. 1997;273:C1828-C1834.
11. Zennadi R, Hines PC, De Castro LM, Cartron J-P, Parise LV, Telen MJ. Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions. Blood. 2004;104:3774-3781.
12. Paszty C, Brion CM, Manci E, et al. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science. 1997;278:876-878.
13. Unthank JL, Lash JM, Nixon JC, Sidner RA, Bohlen HG. Evaluation of carbocyanine-labeled erythrocytes for microvascular measurements. Microvasc Res. 1993;45:193-210.
14. Bloy C, Blanchard D, Hermand P, Kordowicz M, Sonneborn HH, Cartron JP. Properties of the blood group LW glycoprotein and preliminary comparison with Rh proteins. Mol Immunol. 1989;26:1013-1019.
15. Lindberg FP, Lublin DM, Telen MJ, et al. Rh-related antigen CD47 is the signal-transducer integrin-associated protein. J Biol Chem. 1994;269:1567-1570.
16. Galfre G, Howe SC, Milstein C, Butcher GW, Howard JC. Antibodies to major histocompatibility antigens produced by hybrid cell lines. Nature. 1977;266:550-552.
17. Bailly P, Hermand P, Callebaut I, et al. The LW blood group glycoprotein is homologous to intercellular adhesion molecules. Proc Natl Acad Sci U S A. 1994;91:5306-5310.
18. Algire GH, Legallais FY. Recent developments in the transparent-chamber technique as adapted to the mouse. J Natl Cancer Inst. 1949;10:225-253.
19. Kalambur VS, Mahaseth H, Bischof JC, et al. Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopy. Am J Hematol. 2004;77:117-125.
20. Dewhirst MW, Shan S, Cao Y, Moeller B, Yuan F, Li CY. Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. Dis Markers. 2002;18:293-311.
21. Dewhirst MW, Tso CY, Oliver R, Gustafson CS, Secomb TW, Gross JF. Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature. Int J Radiat Oncol Biol Physiol. 1989;17:91-99.
22. Koch WJ, Rockman HA, Samama P, et al. Cardiac function in mice overexpressing the β-adrenergic receptor kinase or an β-ARK inhibitor. Science. 1995;268:1350-1353.
23. Ishihara C, Tsuji M, Hagiwara K, Hioki K, Arikawa J, Azuma I. Transfusion with xenogeneic erythrocytes into SCID mice and their clearance from the circulation. J Vet Med Sci. 1994;56:1149-1154.
24. Rees MA. A novel role for lectins in xenotransplantation. Xenotransplantation. 2005;12:7-12.
25. Sarelius IH, Duling BR. Direct measurement of microvessel hematocrit, red cell flux, velocity, and transit time. Am J Physiol. 1982;243:H1018-H1026.
26. King MR, Bansal D, Kim MB, Sarelius IH. The effect of hematocrit and leukocyte adherence on flow direction in the microcirculation. Ann Biomed Eng. 2004;32:803-814.
27. Turhan A, Weiss LA, Mohandas N, Coller BS, Frenette PS. Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm. Proc Natl Acad Sci U S A. 2002;99:3047-3051.
28. Hines PC, Zen Q, Burney SN, et al. Novel epinephrine and cyclic AMP activation of B-CAM/Lu dependent sickle (SS) RBC adhesion. Blood. 2003;101:3281-3287.
29. Cheung AT, Harmatz P, Wun T, et al. Correlation of abnormal intracranial vessel velocity, measured by transcranial Doppler ultrasonography, with abnormal conjunctival vessel velocity, measured by computer-assisted intravital microscopy, in sickle cell disease. Blood. 2001;97:3401-3404.
30. Montes RA, Eckman JR, Hsu LL, Wick TM. Sickle erythrocyte adherence to endothelium at low shear: role of shear stress in propagation of vasoocclusion. Am J Hematol. 2002;70:216-227.
31. Kaul DK, Tsai HM, Liu XD, Nakada MT, Nagel RL, Coller BS. Monoclonal antibodies to alphavbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood. 2000;95:368-374.
32. Khreiss T, Jozsef L, Chan JS, Filep JG. Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. Cell Signal. 2004;16:801-810.
33. Cambien B, Bergmeier W, Saffaripour S, Mitchell HA, Wagner DD. Antithrombotic activity of TNF-alpha. J Clin Invest. 2003;112:1589-1596.
34. Matsui NM, Varki A, Embury SH. Heparin inhibits the flow adhesion of sickle red blood cells to P-selectin. Blood. 2002;100:3790-3796.
35. Manodori AB. Sickle erythrocytes adhere to fibronectin-thrombospondin- integrin complexes exposed by thrombin-induced endothelial cell contraction. Microvasc. Res. 2001;61:263-274.
36. Garratty G. Blood group antigens as tumor markers, parasitic/bacterial/ viral receptors, and their association with immunologically important proteins. Immunol Invest. 1995;24:213-232.
37. 99mTc-labeled peptide targeted at αvβ3 integrin after murine hindlimb ischemia. Circulation. 2005;111:3255-3260.
38. Wilkinson-Berka JL, Jones D, Taylor G, et al. SB-267268, a nonpeptidic antagonist of alpha(v) beta3 and alpha(v)beta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2006;47:1600-1605.
39. Kaul DK, Liu XD, Zhang X, et al. Peptides based on αv-binding domains of erythrocyte ICAM-4 inhibit sickle red cell-endothelial interactions and vaso-occlusion in the microcirculation. Am J Physiol Cell Physiol. 2006;291:C922-C930.
40. Foltz RM, McLendon RE, Friedman HS, Dodge RK, Bigner DD, Dewhirst MW. A pial window model for the intracranial study of human glioma microvascular function. Neurosurgery. 1995;36:976-985.
41. Acker JC, Marks LB, Spencer DP, et al. Serial in vivo observations of cerebral vasculature after treatment with a large single fraction of radiation. Radiat Res. 1998;149:350-359.
42. Kimura H, Wu NZ, Dodge R, et al. Inhibition of radiation-induced up-regulation of leukocyte adhesion to endothelial cells with the platelet-activating factor inhibitor, BN52021. Int J Radiat Oncol Biol Phys. 1995;33:627-633.
43. Wu NZ, Klitzman B, Dodge R, Dewhirst MW. Diminished leukocyte-endothelium interaction in tumor microvessels. Cancer Res. 1992;52:4265-4268.
44. Bailly P, Tontti E, Hermand P, Cartron J-P, Gahmberg CG. The red cell LW blood group protein is an intercellular adhesion molecule which binds to CD11/CD18 leukocyte integrins. Eur J Immunol. 1995;25:3316-3320.
45. 2 integrins (LFA-1, Mac-1) on the human ICAM4/LW blood group protein. J Biol Chem. 2000;275:26002-26010.
46. Ihanus E, Uotila LM, Toivanen A, Varis M, Gahmberg CG. Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4. Blood. 2007;109:802-810.
47. Brown MD, Wick TM, Eckman JR. Activation of vascular endothelial cell adhesion molecule expression by sickle blood cells. Pediatr Pathol Mol Med. 2001;20:47-72.