Hydroxyurea therapy decreases the in vitro adhesion of sickle erythrocytes to thrombospondin and laminin

British Journal of Haematology

Volumn 109, Issue 2, 2000, Pages 322-327

  Hillery, Cheryl A ^a,b   Du, Ming C ^b   Wang, Winfred C ^c   Scott, J Paul ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b BLOOD RESEARCH INSTITUTE   (United States)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Erythrocyte adhesion; Hydroxyurea; Laminin; Sickle cell disease; Thrombospondin

Indexed keywords

HYDROXYUREA; LAMININ; THROMBOSPONDIN;

ADOLESCENT; ADULT; ARTICLE; BLOOD VESSEL OCCLUSION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE ADHESIVENESS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; PRIORITY JOURNAL; SICKLE CELL; SICKLE CELL ANEMIA; VASCULAR ENDOTHELIUM;

ADOLESCENT; ADULT; ANTISICKLING AGENTS; CELL ADHESION; CELLS, CULTURED; CHILD; ERYTHROCYTES; FEMALE; HUMANS; HYDROXYUREA; LAMININ; MALE; SICKLE CELL TRAIT; THROMBOSPONDINS;

EID: 0034082976     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.02040.x     Document Type: Article

References (40)

1. Balllas, S.K., Dover, G.J. & Charache, S. (1989) Effect of hydroxyurea on the rheological properties of sickle erythrocytes in vivo. American Journal of Hematology, 32, 104-111.
2. Barabino, G.A., McIntire, L.V., Eskin, S.G., Sears, D.A. & Udden, M. (1987) Endothelial cell interactions with sickle cell, sickle trait, mechanically injured, and normal erythrocytes under controlled flow. Blood, 70, 152-157.
3. Barabino, G.A., Wise, R.J., Woodbury, V.A., Zhang, B., Bridges, K.A., Hebbel, R.P., Lawler, J. & Ewenstein, B.M. (1997) Inhibition of sickle erythrocyte adhesion to immobilized thrombospondin by von Willebrand factor under dynamic flow conditions. Blood, 89, 2560-2567.
4. Bridges, K.R., Barabino, G.A., Brugnara, C., Cho, M.R., Christoph, G.W., Dover, G., Ewenstein, B.M., Golan, D.E., Guttmann, C.R., Hofrichter, J., Mulkern, R.V., Zhang, B. & Eaton, W.A. (1996) A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy. Blood, 88, 4701-4710.
5. Brittain, H.A., Eckman, J.R., Swerlick, R.A., Howard, R.J. & Wick, T.M. (1995) Thrombospondin from activated platelets promotes sickle erythrocyte adherence to human microvascular endothelium under physiologic flow: a potential role for platelet activation in sickle cell vaso-occlusion. Blood, 81, 2137-2145.
6. Brugnara, C., Bunn, H.F. & Tosteson, D.C. (1986) Regulation of erythrocyte cation and water content in sickle cell anemia. Science, 232, 388-390.
7. Canessa, M., Spalvins, A. & Nagel, R.L. (1986) Volume-dependent and NEM-stimulated K+.CI-transport is elevated in oxygenated SS, SC and CC human red cells. FEBS Letters, 200, 197-202.
8. Charache, S., Dover, G.J., Moore, R.D., Eckert, S.,Ballas, S.K., Koshy, M., Milner, P.F., Orringer, E.P., Phillips, G.J. & Platt, O.S. (1992) Hydroxyurea: effects on hemoglobin F production in patients with sickle cell anemia [sec comments]. Blood, 79, 2555-2565.
9. Charache, S., Terrin, M.L., Moore, R.D., Dover, G.J., Barton, E.B., Eckert, S.V., McMahon, R.P. & Bonds, D.R. (1995) Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. New England Journal of Medicine, 332, 1317-1322.
10. Charache, S., Barton, F.B., Moore, R.D., Terrin, M.L., Steinberg, M.H., Dover, G.J., Ballas, S.K., McMahon, R.P., Castro, O. & Orringer, E.P. (1996) Hydroxyurea and sickle cell anemia. Clinical utility of a myelosuppressive 'switching' agent. The Multicenter Study of Hydroxyurea in Sickle Cell Anemia. Medicine, 75, 300-326.
11. 1H magnetic resonance imaging changes. Proceedings of the National Academy of Sciences of the United States of America, 86, 3808-3812.
12. Francis, Jr, R.B. (1991) Platelets, coagulation, and fibrinolysis in sickle cell disease: their possible role in vascular occlusion. Blood Coagulation and Fibrinolysis, 2, 341-353.
13. French, J.A.I.I., Kenny, D., Scott, J.P., Hoffmann, R.G., Wood, J.D., Hudetz, A.G. & Hillery, C.A. (1997) Mechanisms of stroke in sickle cell disease: sickle erythrocytes decrease cerebral blood flow in rats after nitric oxide synthase inhibition. Blood, 89, 4591-4599.
14. Gee, B.E. & Platt, O.S. (1995) Sickle reticulocytes adhere to VCAM-1. Blood, 85, 268-274.
15. Hebbel, R.P. (1991) Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology. Blood, 77, 214-237.
16. Hebbel, R.P., Yamada, O., Moldow, CF., Jacob, H.S., White, J.G. & Eaton, J.W. (1980) Abnormal adherence of sickle erythrocytes to cultured vascular endothelium: possible mechanism for microvascular occlusion in sickle cell disease. Journal of Clinical Investigation, 65, 154-160.
17. Hebbel, R.P., Ney, P.A. & Foker, W. (1989) Autoxidation, dehydration, and adhesivity may be related abnormalities of sickle erythrocytes. American Journal of Physiology, 256, C579-C583.
18. Hillery, C.A. (1998) Potential therapeutic approaches for the treatment of vaso-occlusion in sickle cell disease. Current Opinion in Hematology, 5, 151-158.
19. Hillery, C.A., Du, M.C., Montgomery, R.R. & Scott, J.P. (1996) Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin. Blood, 87, 4879-4886.
20. Hoover, R., Rubin, R., Wise, G. & Warren, R. (1979) Adhesion of normal and sickle erythrocytes to endothelial monolayer cultures. Blood, 54, 872-876.
21. Joneckis, C.C., Shock, D.D., Cunningham, M.L., Orringer, E.P. & Parise, L.V. (1996) Glycoprotein IV-independent adhesion of sickle red blood cells to immobilized thrombospondin under flow conditions. Blood, 87, 4862-4870.
22. Jones, D.A., Abbassi, O., McIntire, L.V., McEver, R.P. & Smith, C.W. (1993) P-Selectin mediates neutrophil rolling on histamine-stimulated endothelial cells. Biophysical Journal, 65, 1560-1569.
23. Kaul, D.K., Fabry, M.E. & Nagel, R.L. (1989) Microvascular sites and characteristics of sickle cell adhesion to vascular endothelium in shear flow conditions: pathophysiological implications. Proceedings of the National Academy of Sciences of the United States of America, 86, 3356-3360.
24. Kaul, D.K., Nagel, R.L., Chen, D. & Tsai, H.M. (1995) Sickle erythrocyte-endothelial interactions in microcirculation: the role of von Willebrand factor and implications for vasoocclusion. Blood, 81, 2429-2438.
25. Kaul, D.K., Fabry, M.E., Costantini, F., Rubin, E.M. & Nagel, R.L. (1995) In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse. Journal of Clinical Investigation, 96, 2845-2853.
26. Kaul, D.K., Tsai, H.M., Liu, X.W., Nakada, M.T., Nagel, R.L. & Coller, B.S. (2000) Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell-endothelium interactions induced by platelet-activating factor. Blood, 95, 368-374.
27. Lipowsky, H.H. & Williams, M.E. (1997) Shear rate dependency of red cell sequestration in skin capillaries in sickle cell disease and its variation with vasoocclusive crisis. Microcirculation, 4, 289-301.
28. Nagel, R.L., Bookchin, R.M., Johnson, J., Labie, D., Wajcman, H., Isaac-Sodeye, W.A., Honig, G.R., Schiliro, G., Crookston, J.H. & Matsutomo, K. (1979) Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S. Proceedings of the National Academy of Sciences of the United States of America, 76, 670-672.
29. Natarajan, M., Udden, M.M. & McIntire, L.V. (1996) Adhesion of sickle red blood cells and damage to interleukin-1 beta stimulated endothelial cells under flow in vitro. Blood, 87, 4845-4852.
30. Punzalan, R.C., Du, M.C., Low, P.S., Scott, J.P. & Hillery, C.A. (1997) Role of hydration status in erythrocyte adhesion to thrombospondin (Abstract). Blood, 90, 604a.
31. Rodgers, G.P., Dover, G.J., Noguchi, C.T., Schechter, A.N. & Nienhuis, A.W. (1990) Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea. New England Journal of Medicine, 322, 1037-1045.
32. Scott, J.P., Hillery, C.A., Brown, E.R., Misiewicz, V. & Labotka, R.J. (1996) Hydroxyurea therapy in children severely affected with sickle cell disease. Journal of Pediatrics, 128, 820-828.
33. Slayter, H.S. (1989) Secretion of thrombospondin from human blood platelets. Methods in Enzymology, 169, 251-268.
34. Solovey, A., Lin, Y., Browne, P., Choong, S., Wayner, E. & Hebbel, R.P. (1997) Circulating activated endothelial cells in sickle cell anemia. New England Journal of Medicine, 337, 1584-1590.
35. Stone, P.C., Stuart, J. & Nash, G.B. (1996) Effects of density and of dehydration of sickle cells on their adhesion to cultured endothelial cells. American Journal of Hematology, 52, 135-143.
36. Styles, L.A., Lubin, B., Vichinsky, E., Lawrence, S., Hua, M., Test, S. & Kuypers, F. (1997) Decrease of very late activation antigen-4 and CD36 on reticulocytes in sickle cell patients treated with hydroxyurea. Blood, 89, 2554-2559.
37. Sugihara, K., Sugihara, T., Mohandas, N. & Hebbel, R.P. (1992) Thrombospondin mediates adherence of CD36+ sickle reticulocytes to endothelial cells. Blood, 80, 2634-2642.
38. 1-integrin expression on sickle reticulocytes: vascular cell adhesion molecule-1-dependent binding to endothelium. Blood, 82, 1891-1899.
39. Udani, M., Zen, Q., Cottman, M., Leonard, N., Jefferson, S., Daymont, C. & Truskey, G. & Telen, M.J. (1998) Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. Journal of Clinical Investigation, 101, 2550-2558.
40. Zen, Q., Cottman, M., Truskey, G., Fraser, R. & Telen, M.J. (1999) Critical factors in basal cell adhesion molecule/Lutheran-mediated adhesion to laminin. Journal of Biological Chemistry, 274, 728-734.