Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin

Innate Immunity

Volumn 20, Issue 3, 2014, Pages 301-311

  Chang, Chih Jung ^a,b   Chen, Yi Yuan M ^b   Lu, Chia Chen ^c   Lin, Chuan Sheng ^a,b   Martel, Jan ^a   Tsai, Sheng Hui ^d   Ko, Yun Fei ^e,f   Huang, Tsung Teng ^a   Ojcius, David M ^a,g   Young, John D ^a,e,f,h   Lai, Hsin Chih ^a,b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e Chang Gung Medical Center   (Taiwan)

^f MING CHI UNIVERSITY OF TECHNOLOGY   (Taiwan)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Ganoderma lucidum; granulysin; NCR; NK cell; NKG2D; perforin

Indexed keywords

CELL SURFACE RECEPTOR; GANODERMA LUCIDUM EXTRACT; GRANULYSIN; MITOGEN ACTIVATED PROTEIN KINASE; NATURAL CYTOTOXICITY RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2D; PERFORIN; RECEPTOR; UNCLASSIFIED DRUG; ANTIBODY; GNLY PROTEIN, HUMAN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY K; RNA; SMALL INTERFERING RNA; T LYMPHOCYTE ANTIGEN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; EXOCYTOSIS; GANODERMA LUCIDUM; HUMAN; HUMAN CELL; NATURAL KILLER CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL SURVIVAL; CHEMISTRY; GENETIC TRANSFECTION; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; ANTIBODIES; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; KILLER CELLS, NATURAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY K; PERFORIN; RECEPTORS, CELL SURFACE; REISHI; RNA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 84898954887     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425913491789     Document Type: Article

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