Effect of temperature on thromboelastography and implications for clinical use in newborns undergoing therapeutic hypothermia

Pediatric Research

Volumn 75, Issue 5, 2014, Pages 663-669

  Forman, Katie R ^a,b   Wong, Edward ^a,b   Gallagher, Meanavy ^a   Mccarter, Robert ^a,b   Luban, Naomi L C ^a,b   Massaro, An N ^a,b  

^a CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD SAMPLING; CLINICAL ARTICLE; ELECTROENCEPHALOGRAM; FEMALE; HIGH RISK INFANT; HUMAN; HYPOXIC ISCHEMIC ENCEPHALOPATHY; INDUCED HYPOTHERMIA; LOGISTIC REGRESSION ANALYSIS; MALE; NEWBORN; OBSERVATIONAL STUDY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; TEMPERATURE; THROMBOELASTOGRAPHY; BRAIN ISCHEMIA; HYPERAMMONEMIA; PROCEDURES; RISK;

BLOOD COAGULATION; BRAIN ISCHEMIA; FEMALE; HUMANS; HYPERAMMONEMIA; HYPOTHERMIA, INDUCED; INFANT, NEWBORN; MALE; PROSPECTIVE STUDIES; RISK; TEMPERATURE; THROMBELASTOGRAPHY;

EID: 84898940340     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1038/pr.2014.19     Document Type: Article

References (37)

1. Bauman ME, Cheung PY, Massicotte MP. Hemostasis and platelet dysfunction in asphyxiated neonates. J Pediatr 2011;158:Suppl:e35-9
2. Suzuki S, Morishita S. Hypercoagulability and DIC in high-risk infants. Semin Thromb Hemost 1998;24:463-6
3. Shah P, Riphagen S, Beyene J, Perlman M. Multiorgan dysfunction in infants with post-Asphyxial hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 2004;89:F152-5
4. Sarkar S, Barks JD, Bhagat I, Donn SM. Effects of therapeutic hypothermia on multiorgan dysfunction in asphyxiated newborns: Whole-body cooling versus selective head cooling. J Perinatol 2009;29:558-63
5. Castle V, Andrew M, Kelton J, Giron D, Johnston M, Carter C. Frequency and mechanism of neonatal thrombocytopenia. J Pediatr 1986;108(5 Pt 1):749-55
6. Roberts IA, Murray NA. Thrombocytopenia in the newborn. Curr Opin Pediatr 2003;15:17-23
7. Michelson AD, Barnard MR, Khuri SF, Rohrer MJ, MacGregor H, Valeri CR. The effects of aspirin and hypothermia on platelet function in vivo. Br J Haematol 1999;104:64-8
8. Reed RL 2nd, Johnson TD, Hudson JD, Fischer RP. The disparity between hypothermic coagulopathy and clotting studies. J Trauma 1992;33:465-70
9. Reed RL 2nd, Bracey AW Jr, Hudson JD, Miller TA, Fischer RP. Hypothermia and blood coagulation: Dissociation between enzyme activity and clotting factor levels. Circ Shock 1990;32:141-52
10. Rohrer MJ, Natale AM. Effect of hypothermia on the coagulation cascade. Crit Care Med 1992;20:1402-5
11. Straub A, Breuer M, Wendel HP, Peter K, Dietz K, Ziemer G. Critical temperature ranges of hypothermia-induced platelet activation: Possible implications for cooling patients in cardiac surgery. Thromb Haemost 2007;97:608-16
12. Wolberg AS, Meng ZH, Monroe DM 3rd, Hoffman M. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma 2004;56:1221-8
13. Jacobs SE, Berg M, Hunt R, Tarnow-Mordi WO, Inder TE, Davis PG. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013;1:CD003311
14. Shankaran S. Therapeutic hypothermia for neonatal encephalopathy. Curr Treat Options Neurol 2012;14:608-19
15. Shankaran S, Pappas A, McDonald SA, et al.; Eunice Kennedy Shriver NICHD Neonatal Research Network. Childhood outcomes after hypothermia for neonatal encephalopathy. N Engl J Med 2012;366:2085-92
16. Shankaran S, Laptook AR, Tyson JE, et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. J Pediatr 2012;160:567-572.e3
17. Shankaran S, Laptook AR, Ehrenkranz RA, et al.; National Institute of Child Health and Human Development Neonatal Research Network. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 2005;353:1574-84
18. Azzopardi D, Brocklehurst P, Edwards D, et al.; TOBY Study Group. The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: A randomised controlled trial. BMC Pediatr 2008;8:17
19. Gunn AJ, Wyatt JS, Whitelaw A, et al.; CoolCap Study Group. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr 2008;152:55-8, 58.e1
20. Wyatt JS, Gluckman PD, Liu PY, et al.; CoolCap Study Group. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics 2007;119:912-21
21. Gluckman PD, Wyatt JS, Azzopardi D, et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: Multicentre randomised trial. Lancet 2005;365:663-70
22. Eicher DJ, Wagner CL, Katikaneni LP, et al. Moderate hypothermia in neonatal encephalopathy: Efficacy outcomes. Pediatr Neurol 2005;32:11-7
23. Edwards RM, Naik-Mathuria BJ, Gay AN, Olutoye OO, Teruya J. Parameters of thromboelastography in healthy newborns. Am J Clin Pathol 2008;130:99-102
24. Luddington RJ. Thrombelastography/thromboelastometry. Clin Lab Haematol 2005;27:81-90
25. Scarpelini S, Rhind SG, Nascimento B, et al. Normal range values for thromboelastography in healthy adult volunteers. Braz J Med Biol Res 2009;42:1210-7
26. Nair SC, Dargaud Y, Chitlur M, Srivastava A. Tests of global haemostasis and their applications in bleeding disorders. Haemophilia 2010;16:Suppl 5:85-92
27. Haizinger B, Gombotz H, Rehak P, Geiselseder G, Mair R. Activated thrombelastogram in neonates and infants with complex congenital heart disease in comparison with healthy children. Br J Anaesth 2006;97:545-52
28. Moganasundram S, Hunt BJ, Sykes K, et al. The relationship among thromboelastography, hemostatic variables, and bleeding after cardiopulmonary bypass surgery in children. Anesth Analg 2010;110:995-1002
29. Alexander DC, Butt WW, Best JD, Donath SM, Monagle PT, Shekerdemian LS. Correlation of thromboelastography with standard tests of anticoagulation in paediatric patients receiving extracorporeal life support. Thromb Res 2010;125:387-92
30. Kang Y, Borland LM, Picone J, Martin LK. Intraoperative coagulation changes in children undergoing liver transplantation. Anesthesiology 1989;71:44-7
31. Goobie SM, Soriano SG, Zurakowski D, McGowan FX, Rockoff MA. Hemostatic changes in pediatric neurosurgical patients as evaluated by thrombelastograph. Anesth Analg 2001;93:887-92
32. Chan KL, Summerhayes RG, Ignjatovic V, Horton SB, Monagle PT. Reference values for kaolin-Activated thromboelastography in healthy children. Anesth Analg 2007;105:1610-3, table of contents
33. Christensen RD, Sheffield MJ, Lambert DK, Baer VL. Effect of therapeutic hypothermia in neonates with hypoxic-ischemic encephalopathy on platelet function. Neonatology 2012;101:91-4
34. Fraser CD Jr, Jaquiss RD, Rosenthal DN, et al.; Berlin Heart Study Investigators. Prospective trial of a pediatric ventricular assist device. N Engl J Med 2012;367:532-41
35. Mitchell LG, Goldenberg NA, Male C, Kenet G, Monagle P, Nowak-Göttl U; Perinatal and Paediatric Haemostasis Subcommittee of the SSC of the ISTH. Definition of clinical efficacy and safety outcomes for clinical trials in deep venous thrombosis and pulmonary embolism in children. J Thromb Haemost 2011;9:1856-8
36. Shinya H, Matsuo N, Takeyama N, Tanaka T. Hyperammonemia inhibits platelet aggregation in rats. Thromb Res 1996;81:195-201
37. Polin R. Pathophysiology of metabolic disease of the liver. In: Gibson J, Berry G, eds. Fetal and Neonatal Physiology. Philadelphia, PA: W.B. Saunders Co, 2004:1211-8