Automated measurement of apparent protein solubility to rapidly assess complex parameter interactions

Food and Bioproducts Processing

Volumn 92, Issue 2, 2014, Pages 133-142

  Berg, Annette ^a,b   Schuetz, Maren ^a,c   Dismer, Florian ^a,d   Hubbuch, Juergen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c DIARECT AG   (Germany)

^d NOVO NORDISK A S   (Denmark)

Author keywords

Cohn equation; Excipient screen; Formulation; High throughput experimentation; Precipitation; Protein solubility

Indexed keywords

ENZYMES; IONIC STRENGTH; LIQUID CHROMATOGRAPHY; OPTIMIZATION; PRECIPITATION (CHEMICAL); PROTEINS;

COHN EQUATION; FORMULATION; HIGH THROUGHPUT EXPERIMENTATION; HIGH THROUGHPUT SCREENING METHODS; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; INCLUSION BODY REFOLDING; PROTEIN SOLUBILITY; THERMODYNAMIC SOLUBILITY;

SOLUBILITY;

EID: 84898939682     PISSN: 09603085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fbp.2013.10.002     Document Type: Article

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