Commercial synthesis of a pyrrolotriazine-fluoroindole intermediate to brivanib alaninate: Process development directed toward impurity control

Organic Process Research and Development

Volumn 18, Issue 1, 2014, Pages 89-102

  Pesti, Jaan A ^a   LaPorte, Thomas ^a   Thornton, John E ^a   Spangler, Lori ^a   Buono, Frederic ^a   Crispino, Gerard ^a   Gibson, Frank ^a   Lobben, Paul ^a   Papaioannou, Christos G ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DOSAGE;

BRIVANIB ALANINATE; COMMERCIAL PROCESS; HIGH DOSE; HIGH QUALITY; IMPURITY CONTROL; MINIMALIZATION; PROCESS DEVELOPMENT;

IMPURITIES;

EID: 84898936729     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op400242j     Document Type: Article

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