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Volumn 14, Issue 5, 2010, Pages 1078-1087

Process research and development for the kilogram manufacture of the SRC kinase inhibitor AZD0530

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINATED SOLVENT; MEDICINAL CHEMISTRY; RESEARCH AND DEVELOPMENT; SRC-KINASE; SYNTHETIC ROUTES; TITLE COMPOUNDS;

EID: 77956910733     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100161y     Document Type: Article
Times cited : (17)

References (13)
  • 3
    • 0004235357 scopus 로고
    • Wiley & Sons: New York,; Collect. Vol. I, pp - 330.
    • Marvel, C. S.; Hiers, G. S. Organic Syntheses; Wiley & Sons: New York, 1941; Collect. Vol. I, pp 327 - 330.
    • (1941) Organic Syntheses , pp. 327
    • Marvel, C.S.1    Hiers, G.S.2
  • 8
    • 77956893353 scopus 로고    scopus 로고
    • (R3); U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER): Rockville, MD.
    • ICH Harmonised Tripartite Guideline, ICH Q3C Impurities: Guideline for Residual Solvents, (R3); U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER): Rockville, MD, 2005.
    • (2005) ICH Harmonised Tripartite Guideline, ICH Q3C Impurities: Guideline for Residual Solvents
  • 11
    • 77956929637 scopus 로고    scopus 로고
    • The use of concentrated sulphuric acid in lab experiments frequently resulted in ejection of the reaction mixture from the vessel, presumably due to the heat generated by the interaction of sulphuric acid with the water released by the reaction. By using sulphuric acid which already contained a small amount of water, this could be prevented
    • The use of concentrated sulphuric acid in lab experiments frequently resulted in ejection of the reaction mixture from the vessel, presumably due to the heat generated by the interaction of sulphuric acid with the water released by the reaction. By using sulphuric acid which already contained a small amount of water, this could be prevented.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.