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Volumn 106, Issue 7, 2006, Pages 2583-2595

Process Chemistry: The science, business, logic, and logistics

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL INDUSTRY; CHEMICAL PLANTS; DRUG PRODUCTS PLANTS; ENVIRONMENTAL IMPACT; INDUSTRIAL PLANTS; SAFETY FACTOR;

EID: 33747041670     PISSN: 00092665     EISSN: None     Source Type: Journal    
DOI: 10.1021/cr040677v     Document Type: Review
Times cited : (69)

References (70)
  • 1
    • 4644311740 scopus 로고    scopus 로고
    • Major synthetic routes for modern herbicide classes and agrochemical characteristics
    • In Böger, P., Wakabayashi, K., Hirai, K., Eds.; Springer-Verlag: Berlin
    • Hirai, K.; Uchida, A.; Ohno, R. Major synthetic routes for modern herbicide classes and agrochemical characteristics. In Herbicide Classes in Development: mode of action, targets, genetic engineering, chemistry; Böger, P., Wakabayashi, K., Hirai, K., Eds.; Springer-Verlag: Berlin, 2002.
    • (2002) Herbicide Classes in Development: Mode of Action, Targets, Genetic Engineering, Chemistry
    • Hirai, K.1    Uchida, A.2    Ohno, R.3
  • 3
    • 33747078477 scopus 로고    scopus 로고
    • Baker, D. R., Fenyes, J. G., Lahm, G. P., Selby, T. P., Stevenson, T. M., Eds.; ACS Symposium Series 800; American Chemical Society: Washington, DC
    • Synthesis and Chemistry of Agrochemicals VI; Baker, D. R., Fenyes, J. G., Lahm, G. P., Selby, T. P., Stevenson, T. M., Eds.; ACS Symposium Series 800; American Chemical Society: Washington, DC, 2002.
    • (2002) Synthesis and Chemistry of Agrochemicals VI
  • 7
    • 20444439328 scopus 로고    scopus 로고
    • According to a recent ACS survey, pharmaceutical and related fields account for 21.6% of chemists employed full time (vs 12% in 1985). For details
    • According to a recent ACS survey, pharmaceutical and related fields account for 21.6% of chemists employed full time (vs 12% in 1985). For details, see: Heylin, M. Chem. Eng. News 2005, 83 (31), 41-51. (http://pubs.acs.org/cen/acsnews/83/pdf/8331salary.pdf).
    • (2005) Chem. Eng. News , vol.83 , Issue.31 , pp. 41-51
    • Heylin, M.1
  • 8
    • 0004030277 scopus 로고
    • Morin, R. B., Gorman, M., Eds.; Academic Press: New York
    • Chemistry and Biology of β-lactams Antibiotics; Morin, R. B., Gorman, M., Eds.; Academic Press: New York, 1982; Vols. I-III.
    • (1982) Chemistry and Biology of β-Lactams Antibiotics , vol.1-3
  • 9
    • 0013405561 scopus 로고
    • Laird, T. Chem. Br. 1989, 25, 1208-1211.
    • (1989) Chem. Br. , vol.25 , pp. 1208-1211
    • Laird, T.1
  • 10
    • 0000541921 scopus 로고
    • Development and scale-up of Process for the Manufacturing of New Pharmaceutical
    • In Hansch, C., Sammes, P. G., Taylor, J. B., Drayton, C. J., Eds.; Pergamon Press: Oxford, U.K
    • Laird, T. Development and scale-up of Process for the Manufacturing of New Pharmaceutical. In Comprehensive Medicinal Chemistry; Hansch, C., Sammes, P. G., Taylor, J. B., Drayton, C. J., Eds.; Pergamon Press: Oxford, U.K., 1990; Vol. 1, pp 321-359.
    • (1990) Comprehensive Medicinal Chemistry , vol.1 , pp. 321-359
    • Laird, T.1
  • 13
    • 33747064975 scopus 로고
    • Lee, S., Robinson, G. E., Eds.; Oxford Science: Oxford, U.K
    • Process Development - from Grams to Kilos; Lee, S., Robinson, G. E., Eds.; Oxford Science: Oxford, U.K., 1995.
    • (1995) Process Development - From Grams to Kilos
  • 22
    • 33747071081 scopus 로고    scopus 로고
    • Nafissi M., Ragan, J. A., DeVries, K. M., Eds.; ACS Symposium Series 817; American Chemical Society: Washington, DC
    • From Bench to Pilot Plant: Process Research in the Pharmaceutical Industry; Nafissi M., Ragan, J. A., DeVries, K. M., Eds.; ACS Symposium Series 817; American Chemical Society: Washington, DC, 2002.
    • (2002) From Bench to Pilot Plant: Process Research in the Pharmaceutical Industry
  • 23
    • 33747043997 scopus 로고    scopus 로고
    • Abdel-Magid, A. F., Ragan, J. A., Eds.; ACS Symposium Series 870; American Chemical Society: Washington, DC
    • Chemical Process Research: The Art of Practical Organic Synthesis; Abdel-Magid, A. F., Ragan, J. A., Eds.; ACS Symposium Series 870; American Chemical Society: Washington, DC, 2003.
    • (2003) Chemical Process Research: The Art of Practical Organic Synthesis
  • 26
    • 33747042173 scopus 로고    scopus 로고
    • Perspectives in Process Chemistry by American Chemical Society
    • Perspectives in Process Chemistry by American Chemical Society (www.chemistry.org);
  • 27
    • 33747050872 scopus 로고    scopus 로고
    • Midwest Pharmaceutical Process Chemistry Consortium (MPPCC) by major research-based pharmaceutical companies
    • and Midwest Pharmaceutical Process Chemistry Consortium (MPPCC) by major research-based pharmaceutical companies (www.mppcc.com);
  • 28
    • 33747056554 scopus 로고    scopus 로고
    • hosted by Rhodia Pharm Solutions; the Siegfried Symposium on New Methods in Process Chemistry, University of Zurich
    • the Annual International Conference on Process Chemistry and Technology, hosted by Rhodia Pharm Solutions; the Siegfried Symposium on New Methods in Process Chemistry, University of Zurich.
    • The Annual International Conference on Process Chemistry and Technology
  • 29
    • 33747048076 scopus 로고    scopus 로고
    • For the Organic Process Research & Development journal website, go to
    • For the Organic Process Research & Development journal website, go to http://pubs.acs.org/journals/oprdfk/.
  • 30
    • 0008559152 scopus 로고
    • For a detailed explanation of the modern drug development process, Smith, C. G., Ed.; CRC Press: Boca Raton, FL, The website of the Pharmaceutical Research and Manufacturers of America (PhRMA) is also a useful resource for current development
    • For a detailed explanation of the modern drug development process, see: The Process of New Drug Discovery and Development; Smith, C. G., Ed.; CRC Press: Boca Raton, FL, 1992. The website of the Pharmaceutical Research and Manufacturers of America (PhRMA) is also a useful resource for current development (http://www.phrma.org).
    • (1992) The Process of New Drug Discovery and Development
  • 31
    • 20744445884 scopus 로고    scopus 로고
    • US FDA CDER report; Department of Health and Human Services, U.S. Food and Drug Administration: Rockville, MD
    • Pharmaceutical cGMPs for the 21st Century - A Risk-Based Approach; US FDA CDER report; Department of Health and Human Services, U.S. Food and Drug Administration: Rockville, MD, 2004 (http://www.fda.gov/cder/gmp/ gmp2004/GMP_finalreport2004.htm).
    • (2004) Pharmaceutical CGMPs for the 21st Century - A Risk-Based Approach
  • 32
    • 33747060416 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration: Rockville, MD
    • Q8 Pharmaceutical Development, A draft guidance for industry; U.S. Food and Drug Administration: Rockville, MD, 2005 (http://www.fda.gov/ohrms/ dockets/98fr/2005d-0021-gd1000.pdf).
    • (2005) Q8 Pharmaceutical Development, A Draft Guidance for Industry
  • 34
    • 33747062666 scopus 로고    scopus 로고
    • content at
    • See also content at http://apic.cefic.org/pub/IGMP-API9604.pdf.
  • 35
    • 0003812821 scopus 로고    scopus 로고
    • Harvard Business School Press: Cambridge, MA
    • Pisano, G. The Development Factory; Harvard Business School Press: Cambridge, MA, 1997.
    • (1997) The Development Factory
    • Pisano, G.1
  • 37
    • 33747083149 scopus 로고    scopus 로고
    • Regulatory starting materials refers to the raw materials or intermediates for the production of drug substances designated as starting materials according to guidelines provided by the U.S. Food and Drug Administration. They signify the start of the manufacturing process regulated by GMPs (good manufacturing practices). For details, http://www.fda.gov/cder/guidance, and http://www.fda.gov/cder/guidance/ 1289dft.pdf
    • Regulatory starting materials refers to the raw materials or intermediates for the production of drug substances designated as starting materials according to guidelines provided by the U.S. Food and Drug Administration. They signify the start of the manufacturing process regulated by GMPs (good manufacturing practices). For details, see http://www.fda.gov/cder/guidance, http://www.fda.gov/cder/guidance, and http://www.fda.gov/cder/guidance/1289dft.pdf.
  • 41
    • 0036858544 scopus 로고    scopus 로고
    • For a series of recent articles on safety of chemical processes, 876-942
    • For a series of recent articles on safety of chemical processes, see: Org. Process Res. Dev. 2002, 6, 876-942; 2005, 9, 951-1012.
    • (2002) Org. Process Res. Dev. , vol.6 , pp. 876-942
  • 42
    • 0004221757 scopus 로고    scopus 로고
    • 2nd ed.; Barton, J., Rogers, R., Eds.; Institute of Chemical Engineers: Rugby, U.K
    • Chemical Reaction Hazards, 2nd ed.; Barton, J., Rogers, R., Eds.; Institute of Chemical Engineers: Rugby, U.K., 1996.
    • (1996) Chemical Reaction Hazards
  • 47
    • 0003830209 scopus 로고
    • 2nd ed.; Abbott, J. A., Ed.; Institution of Chemical Engineers: Rugby, U.K
    • Prevention of Fires and Explosions in Dryers. A User Guide, 2nd ed.; Abbott, J. A., Ed.; Institution of Chemical Engineers: Rugby, U.K., 1990.
    • (1990) Prevention of Fires and Explosions in Dryers. A User Guide
  • 48
    • 1442294628 scopus 로고    scopus 로고
    • Waste minimization in pharmaceutical process development: Principles, practice and challenges
    • In Clark, J., Macquarrie, D., Eds.; Blackwell Science Ltd: Oxford, U.K
    • Zhang, T. Y. Waste minimization in pharmaceutical process development: principles, practice and challenges. In Handbook of Green Chemistry and Technology; Clark, J., Macquarrie, D., Eds.; Blackwell Science Ltd: Oxford, U.K., 2002.
    • (2002) Handbook of Green Chemistry and Technology
    • Zhang, T.Y.1
  • 51
  • 54
    • 19744366251 scopus 로고    scopus 로고
    • and references therein
    • Sheldon, R. A. Green Chem. 2005, 7, 267 and references therein.
    • (2005) Green Chem. , vol.7 , pp. 267
    • Sheldon, R.A.1
  • 57
    • 33747055013 scopus 로고    scopus 로고
    • For US FDA's Process Analytical Technology (PAT) Initiative
    • For US FDA's Process Analytical Technology (PAT) Initiative, see http://www.fda.gov/cder/OPS/PAT.htm.
  • 61
    • 0004294969 scopus 로고    scopus 로고
    • 4th ed.; Butterworth-Heinemann: Oxford, U.K
    • Mullin, J. W. Crystallization, 4th ed.; Butterworth-Heinemann: Oxford, U.K., 2001.
    • (2001) Crystallization
    • Mullin, J.W.1
  • 63
    • 33747036898 scopus 로고    scopus 로고
    • For a series of special issues on polymorphism and crystallization process development, 370-371; 2005, 9, 857-942
    • For a series of special issues on polymorphism and crystallization process development, see: Org. Process Res. Dev., 2000, 4, 370-371; 2003, 7, 957-1027; 2005, 9, 857-942.
    • (2000) Org. Process Res. Dev. , vol.4-7 , pp. 957-1027
  • 67
    • 0004220870 scopus 로고
    • Nicolaou, K. C., Sorensen, E., Eds.; VCH: Weinheim, Germany
    • Classics in Total Synthesis; Nicolaou, K. C., Sorensen, E., Eds.; VCH: Weinheim, Germany, 1995.
    • (1995) Classics in Total Synthesis
  • 69
    • 33747068199 scopus 로고    scopus 로고
    • note
    • Key assumptions: Eight step linear synthesis as shown in Figure 2. Each step is 90% in yield except as noted. Each substrate fragment (A, B,..., I) has a molecular weight of 50 and a cost of $300/kg; all steps were run at 10 volume concentration [L(solvent)/kg(total weight of substrates)] except as noted. Solvent charge is $2/L. Conversion cost is assigned as a function of reaction volume to reflect its dependence on throughput.
  • 70
    • 0035817076 scopus 로고    scopus 로고
    • For an excellent attempt at objectively quantifying synthetic efficiencies using intricacy quotient (IQ)
    • For an excellent attempt at objectively quantifying synthetic efficiencies using intricacy quotient (IQ), see Fuchs, P. L. Tetrahedron, 2001, 57, 6855.
    • (2001) Tetrahedron , vol.57 , pp. 6855
    • Fuchs, P.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.