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Key assumptions: Eight step linear synthesis as shown in Figure 2. Each step is 90% in yield except as noted. Each substrate fragment (A, B,..., I) has a molecular weight of 50 and a cost of $300/kg; all steps were run at 10 volume concentration [L(solvent)/kg(total weight of substrates)] except as noted. Solvent charge is $2/L. Conversion cost is assigned as a function of reaction volume to reflect its dependence on throughput.
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