Clitocine targets Mcl-1 to induce drug-resistant human cancer cell apoptosis in vitro and tumor growth inhibition in vivo

Apoptosis

Volumn 19, Issue 5, 2014, Pages 871-882

  Sun, Jian Guo ^a,b   Li, Hua ^a   Li, Xia ^a   Zeng, Xueli ^a   Wu, Ping ^a,b   Fung, Kwok Pui ^b   Liu, Fei Yan ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Cancer; Clitocine; Drug resistance; Mcl 1

Indexed keywords

AMINONUCLEOSIDE; CASPASE 3; CASPASE 8; CASPASE 9; CLITOCINE; CYTOCHROME C; PROTEIN BAK; PROTEIN BAX; PROTEIN MCL 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER RESISTANCE; CANCER THERAPY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; MALE; MICE; MICE, NUDE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN TRANSPORT; PYRIMIDINE NUCLEOSIDES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84898904166     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-0969-0     Document Type: Article

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