Pheophorbide a, an active component in scutellaria barbata, reverses P-glycoprotein-mediated multidrug resistance on a human hepatoma cell line R-HepG2

Cancer Biology and Therapy

Volumn 6, Issue 4, 2007, Pages 504-509

  Tang, Patrick Ming Kuen ^a   Chan, Judy Yuet Wa ^a   Zhang, Dong Mei ^a   Au, Shannon Wing Ngor ^a   Fong, Wing Ping ^a   Kong, Siu Kai ^a   Tsui, Stephen Kwok Wing ^a   Waye, Mary Mui Yee ^a   Mak, Thomas Chung Wai ^a   Fung, Kwok Pui ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cell cycle arrest; Multi drug resistance; P glycoprotein; Pheophorbide a; R HepG2 cells; Scutellaria barbata

Indexed keywords

GLYCOPROTEIN P; PHEOPHORBIDE;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL LINE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HEPATOMA CELL; HUMAN; HUMAN CELL; IC 50; MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; SCUTELLARIA; SCUTELLARIA BARBATA;

EID: 34548286382     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.4.3814     Document Type: Article

References (14)

1. Hung H. Curr cancer drug targets: Treatment modalities for hepatocellular carcinoma. 2005; 5:131-8.
2. Johnson PJ. Hepatocellular carcinoma: Is current therapy really altering outcome? Gut 2002; 51:459-62.
3. Gottesman MM, Ling V. The molecular basis of multidrug resistance in cancer: The early years of P-glycoprotein research. FEBS Lett 2006; 580:998-1009.
4. Tam WH, Wang SW, Leung YM. Zhong yao ban zhi lian de yan jiu jin zhan (in Chinese). Xi Nan Guo Fang Yi Yao 2002; 12:152-3.
5. Lee TK, Lee DK, Kim DI, Lee YC, Chang YC, Kim CH. Inhibitory effects of Scutellaria barbata D. Don on human uterine leiomyomal smooth muscle cell proliferation through cell cycle analysis. Int Immunopharmacol 2004; 4:447-54.
6. Chan JY, Tang PM, Hon PM, Au SW, Tsui SK, Waye MM, Kong SK, Mak TC, Fung KP. Pheophorbide a, a major antitumor component purified from Scutellaria barbata, induces apoptosis in human hepatocellular carcinoma cells. Planta Med 2006; 72:28-33.
7. Hibasami H, Kyohkon M, Ohwaki S, Katsuzaki H, Imai K, Nakagawa M, Ishi Y, Komiya T. Pheophorbide a, a moiety of chlorophyll a, induces apoptosis in human lymphoid leukemia molt 4B cells. Int J Mol Med 2000; 6:277-9.
8. Nakamura Y, Murakami A, Koshimizu K, Ohigashi H. Inhibitory effect of pheophorbide a, a chlorophyll-related compound, on skin tumor promotion in ICR mouse. Cancer Lett 1996; 108:247-55.
9. Chan JY, Chu AC, Fung KP. Inhibition of P-glycoprotein expression and reversal of drug resistance of human hepatoma HepG2 cells by multidrug resistance gene (mdr1) antisense RNA. Life Sci 2000; 67:2117-124.
10. Yin X, Zhou J, Jie C, Xing D, Zhang Y. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sci 2004; 75:2233-44.
11. Gottesman MM. Mechanisms of cancer drug resistance. Annu Rev Med 2002; 53:615-27.
12. Wang C, Zhang JX, Shen XL, Wan CK, Tse AK, Fong WF. Reversal of P-glycoprotein-mediated multidrug resistance by Alisol B 23-acetate. Biochem Pharmacol 2004; 68:843-55.
13. Bortner CD, Oldenburg NB, Cidlowski JA. The role of DNA fragmentation in apoptosis. Trends Cell Biol 1995; 5:21-6.
14. Sanchez I, Dynlacht BD. New insights into cyclins, CDKs, and cell cycle control. Semin Cell Dev Biol 2005; 16:311-21.