Association between MDM2 rs 2279744 polymorphism and breast cancer susceptibility: A meta-analysis based on 9,788 cases and 11,195 controls

Therapeutics and Clinical Risk Management

Volumn 10, Issue 1, 2014, Pages 269-277

  Gao, Jie ^a   Kang, An Jing ^a   Lin, Shuai ^a   Dai, Zhi Jun ^a   Zhang, Shu Qun ^a   Liu, Di ^a   Zhao, Yang ^a   Yang, Peng Tao ^a   Wang, Meng ^a   Wang, Xi Jing ^a  

^a THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Breast cancer; MDM2; Meta analysis; Single nucleotide polymorphism; Susceptibility

Indexed keywords

PROTEIN MDM2;

ARTICLE; ASIAN; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CAUCASIAN; ETHNICITY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HUMAN; MDM2 GENE;

EID: 84898879762     PISSN: 11766336     EISSN: 1178203X     Source Type: Journal    
DOI: 10.2147/TCRM.S60680     Document Type: Article

References (45)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63(1):11-30.
2. Bradbury AR, Olopade OI. Genetic susceptibility to breast cancer. Rev Endocr Metab Disord. 2007;8(3):255-267.
3. Wolff MS, Weston A. Breast cancer risk and environmental exposures. Environ Health Perspect. 1997;105:891-896.
4. Hulka BS, Moorman PG. Breast cancer: hormones and other risk factors. Maturitas. 2008;61(1-2):203-213; discussion 213.
5. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell. 1997;88(3):323-331.
6. Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell. 1992;69(7):1237-1245.
7. Bartel F, Meye A, Wurl P, et al. Amplification of the MDM2 gene, but not expression of splice variants of MDM2 MRNA, is associated with prognosis in soft tissue sarcoma. Int J Cancer. 2001;95:168-175.
8. Bond GL, Hu W, Bond EE, et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. 2004;119(5):591-602.
9. Rayburn E, Zhang R, He J, Wang H. MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy. Curr Cancer Drug Targets. 2005;5:27-41.
10. Hu Z, Jin G, Wang L, Chen F, Wang X, Shen H. MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies. Cancer Epidemiol Biomarkers Prev. 2007;16(12):2717-2723.
11. Menin C, Scaini M, De Salvo G, et al. Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. J Natl Cancer Inst. 2006;98:285-288.
12. Ohmiya N, Taguchi A, Mabuchi N, et al. MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis. J Clin Oncol. 2006;24:4434-4440.
13. Yoon YJ, Chang HY, Ahn SH, et al. MDM2 and p53 polymorphisms are associated with the development of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. Carcinogenesis. 2008;29(6):1192-1196.
14. Schmidt MK, Reincke S, Broeks A, et al. Do MDM2 SNP309 and TP53R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium. Cancer Res. 2007;67(19):9584-9590.
15. Fu Q, Zhang G, Chen H, Zheng Y, Cheng J. Current evidence on the relationship between SNP309 polymorphism in the MDM2 gene and colorectal cancer risk. Tumour Biol. 2013;34(6):3721-3729.
16. Boersma BJ, Howe TM, Goodman JE, et al. Association of breast cancer outcome with status of p53 and MDM2 SNP309. J Natl Cancer Inst. 2006;98:911-919.
17. Campbell IG, Eccles DM, Choong DY. No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer. Cancer Lett. 2006;240:195-197.
18. Millikan RC, Heard K, Winkel S, et al. No association between the MDM2-309 T/G promoter polymorphism and breast cancer in African-Americans or Whites. Cancer Epidemiol Biomarkers Prev. 2006;15:175-177.
19. Petenkaya A, Bozkurt B, Akilli-Ozturk O, Kaya HS, Gur-Dedeoglu B, Yulug IG. Lack of association between the MDM2-309 polymorphism and breast cancer risk. Anticancer Res. 2006;26:4975-4977.
20. Wilkening S, Bermejo JL, Burwinkel B, et al. The single nucleotide polymorphism IVS1+309 in mouse double minute 2 does not affect risk of familial breast cancer. Cancer Res. 2006;66(2):646-648.
21. Ma H, Hu Z, Zhai X, et al. Polymorphisms in the MDM2 promoter and risk of breast cancer: a case-control analysis in a Chinese population. Cancer Lett. 2006;240:261-267.
22. Wasielewski M, Nagel JH, Brekelmans C, et al. MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling. Breast Cancer Res Treat. 2007;104:153-157.
23. Cox DG, Deer D, Guo Q, et al. The p53 Arg 72 Pro and MDM2-309 polymorphisms and risk of breast cancer in the nurses' health studies. Cancer Causes Control. 2007;18(6):621-625.
24. Lum SS, Chua HW, Li H, et al. MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population. Carcinogenesis. 2008;29(4):754-761.
25. Singh V, Rastogi N, Mathur N, Singh K, Singh MP. Association of polymorphism in MDM-2 and p53 genes with breast cancer risk in Indian women. Ann Epidemiol. 2008;18(1):48-57.
26. Paulin FE, O'Neill M, McGregor G, et al. MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism. BMC Cancer. 2008;8:281.
27. Krekac D, Brozkova K, Knoflickova D, et al. MDM2SNP309 does not associate with elevated MDM2 protein expression or breast cancer risk. Oncology. 2008;74(1-2):84-87.
28. Yarden RI, Friedman E, Metsuyanim S, Olender T, Ben-Asher E, Papa MZ. MDM2 SNP309 accelerates breast and ovarian carci-nogenesis in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent. Breast Cancer Res Treat. 2008;111:497-504.
29. Lang A, Palmebäck Wegman P, Wingren S. The significance of MDM2 SNP309 and p53 Arg72Pro in young women with breast cancer. Oncol Rep. 2009;22(3):575-579.
30. Sun YF, Leu JD, Chen SM, Lin IF, Lee YJ. Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer. BMC Cancer. 2009;9:13.
31. Koh WP, Van Den Berg D, Jin A, Wang R, Yuan JM, Yu MC. Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer risk among Chinese women in Singapore. Breast Cancer Res Treat. 2011;130(3):1011-1019.
32. Leu JD, Wang CY, Tsai HY, Lin IF, Chen RC, Lee YJ. Involvement of p53 R72P polymorphism in the association of MDM2-SNP309 with breast cancer. Oncol Rep. 2011;25(6):1755-1763.
33. Knappskog S, Bjørnslett M, Myklebust LM, et al. The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians. Cancer Cell. 2011;19(2):273-282.
34. Alshatwi AA, Hasan TN, Shafi G, Alsaif MA, Al-Hazzani AA, Alsaif AA. A single-nucleotide polymorphism in the TP53 and MDM-2 gene modifies breast cancer risk in an ethnic Arab population. Fundam Clin Pharmacol. 2012;26(3):438-443.
35. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996;273:1516-1517.
36. Wilkening S, Bermejo JL, Hemminki K. MDM2 SNP309 and cancer risk: a combined analysis. Carcinogenesis. 2007;28:2262-2267.
37. Jiang O, Zhou R, Wu D, Liu Y, Wu W, Cheng N. CYP2E1 polymorphisms and colorectal cancer risk: a HuGE systematic review and meta-analysis. Tumor Biol. 2013;34:1215-1224.
38. Wan Y, Wu W, Yin Z, Guan P, Zhou B. MDM2 SNP309, gene-gene interaction, and tumor susceptibility: an updated meta-analysis. BMC Cancer. 2011;11:208.
39. Wo X, Han D, Sun H, et al. MDM2 SNP309 contributes to tumor susceptibility: a meta-analysis. J Genet Genomics. 2011;38(8): 341-350.
40. Bond GL, Hirshfield KM, Kirchhoff T, et al. MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res. 2006;66:5104-5110.
41. Toyama T, Zhang Z, Nishio M, et al. Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients. Breast Cancer Res. 2007;9(3):R34.
42. Chrisanthar R, Knappskog S, Løkkevik E, et al. Predictive and prognostic impact of TP53 mutations and MDM2 promoter genotype in primary breast cancer patients treated with epirubicin or paclitaxel. PLoS One. 2011;6(4):e19249.
43. Ma YY, Guan TP, Yao HB, et al. The MDM2 309 T. G polymorphism and ovarian cancer risk: a meta-analysis of 1534 cases and 2211 controls. PLoS One. 2013;8(1):e55019.
44. Economopoulos KP, Sergentanis TN. Differential effects of MDM2 SNP309 polymorphism on breast cancer risk along with race: a meta-analysis. Breast Cancer Res Treat. 2010;120(1):211-216.
45. Lohmueller KE, Bustamante CD, Clark AG. The effect of recent admixture on inference of ancient human population history. Genetics. 2010;185(2):611-622.