-
1
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
Momand,J. et al. (1992) The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237-1245.
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
-
2
-
-
0037329056
-
The p53-Mdm2 module and the ubiquitin system
-
Michael,D. et al. (2003) The p53-Mdm2 module and the ubiquitin system. Semin. Cancer Biol., 13, 49-58.
-
(2003)
Semin. Cancer Biol
, vol.13
, pp. 49-58
-
-
Michael, D.1
-
3
-
-
14644417208
-
p53-independent activities of MDM2 and their relevance to cancer therapy
-
Zhang,Z. et al. (2005) p53-independent activities of MDM2 and their relevance to cancer therapy. Curr. Cancer Drug Targets, 5 9-20.
-
(2005)
Curr. Cancer Drug Targets
, vol.5
, pp. 9-20
-
-
Zhang, Z.1
-
4
-
-
8844278362
-
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
-
Bond,G.L. et al. (2004) A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell, 119, 591-602.
-
(2004)
Cell
, vol.119
, pp. 591-602
-
-
Bond, G.L.1
-
5
-
-
21344470650
-
A single nucleotide polymorphism in the MDM2 gene: From a molecular and cellular explanation to clinical effect
-
Bond,G.L. et al. (2005) A single nucleotide polymorphism in the MDM2 gene: From a molecular and cellular explanation to clinical effect. Cancer Res., 65, 5481-5484.
-
(2005)
Cancer Res
, vol.65
, pp. 5481-5484
-
-
Bond, G.L.1
-
6
-
-
0034644506
-
Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF
-
Ries,S. et al. (2000) Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell, 103, 321-330.
-
(2000)
Cell
, vol.103
, pp. 321-330
-
-
Ries, S.1
-
7
-
-
0029131447
-
A functional p53-responsive intronic promoter is contained within the human mdm2 gene
-
Zauberman,A. et al. (1995) A functional p53-responsive intronic promoter is contained within the human mdm2 gene. Nucleic Acids Res. 23, 2584-2592.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 2584-2592
-
-
Zauberman, A.1
-
8
-
-
22844432020
-
A chromatin-associated and transcriptionally in-active p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells
-
Arva,N.C. et al. (2005) A chromatin-associated and transcriptionally in-active p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells. J. Biol. Chem., 280, 26776-26787.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 26776-26787
-
-
Arva, N.C.1
-
9
-
-
34047247060
-
A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells
-
Hu,W. et al. (2007) A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res., 67, 2757-2765.
-
(2007)
Cancer Res
, vol.67
, pp. 2757-2765
-
-
Hu, W.1
-
10
-
-
33847048947
-
Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer
-
Jun,H.J. et al. (2007) Combined effects of p73 and MDM2 polymorphisms on the risk of lung cancer. Mol. Carcinog., 46 100-105.
-
(2007)
Mol. Carcinog
, vol.46
, pp. 100-105
-
-
Jun, H.J.1
-
11
-
-
33750297735
-
MDM2 309TG polymorphism. and risk of lung cancer in a Korean population
-
Park,S.H. et al. (2006) MDM2 309TG polymorphism. and risk of lung cancer in a Korean population. Lung Cancer, 54, 19-24.
-
(2006)
Lung Cancer
, vol.54
, pp. 19-24
-
-
Park, S.H.1
-
12
-
-
0037098199
-
Quantifying heterogeneity in a meta-analysis
-
Higgins,J.P., Thompson,S.G. et al. (2002) Quantifying heterogeneity in a meta-analysis. Stat. Med., 21, 1539-1558.
-
(2002)
Stat. Med
, vol.21
, pp. 1539-1558
-
-
Higgins, J.P.1
Thompson, S.G.2
-
13
-
-
33744899069
-
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner
-
Bond,G.L. et al. (2006) MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner. Cancer Res., 66 5104-5110.
-
(2006)
Cancer Res
, vol.66
, pp. 5104-5110
-
-
Bond, G.L.1
-
14
-
-
34447540243
-
MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling
-
Wasielewski,M. et al. (2007) MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling. Breast Cancer Res. Treat., 104, 153-157.
-
(2007)
Breast Cancer Res. Treat
, vol.104
, pp. 153-157
-
-
Wasielewski, M.1
-
15
-
-
33746218700
-
No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer
-
Campbell,I.G. et al. (2006) No association of the MDM2 SNP309 polymorphism with risk of breast or ovarian cancer. Cancer Lett., 240, 195-197.
-
(2006)
Cancer Lett
, vol.240
, pp. 195-197
-
-
Campbell, I.G.1
-
16
-
-
33745612767
-
Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers
-
Copson,E.R. et al. (2006) Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers. BMC Cancer, 6, 80.
-
(2006)
BMC Cancer
, vol.6
, pp. 80
-
-
Copson, E.R.1
-
17
-
-
33746239400
-
Polymorphisms in the MDM2 promoter and risk of breast cancer: A case-control analysis in a Chinese population
-
Ma,H. et al. (2006) Polymorphisms in the MDM2 promoter and risk of breast cancer: A case-control analysis in a Chinese population. Cancer Lett., 240, 261-267.
-
(2006)
Cancer Lett
, vol.240
, pp. 261-267
-
-
Ma, H.1
-
18
-
-
33645459643
-
No association between the MDM2 - 309 T/G promoter polymorphism and breast cancer in African-Americans or Whites
-
Millikan,R.C. et al. (2006) No association between the MDM2 - 309 T/G promoter polymorphism and breast cancer in African-Americans or Whites. Cancer Epidemiol. Biomarkers Prev., 15, 175-177.
-
(2006)
Cancer Epidemiol. Biomarkers Prev
, vol.15
, pp. 175-177
-
-
Millikan, R.C.1
-
19
-
-
31544482118
-
The single nucleotide polymorphism IVS1 + 309 in mouse double minute 2 does not affect risk of familial breast cancer
-
Wilkening,S. et al. (2006) The single nucleotide polymorphism IVS1 + 309 in mouse double minute 2 does not affect risk of familial breast cancer. Cancer Res., 66, 646-648.
-
(2006)
Cancer Res
, vol.66
, pp. 646-648
-
-
Wilkening, S.1
-
20
-
-
33745783716
-
Association of breast cancer outcome with status of p53 and MDM2 SNP309
-
Boersma,B.J. et al. (2006) Association of breast cancer outcome with status of p53 and MDM2 SNP309. J. Natl Cancer Inst., 98 911-919.
-
(2006)
J. Natl Cancer Inst
, vol.98
, pp. 911-919
-
-
Boersma, B.J.1
-
21
-
-
33845944092
-
Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk
-
Petenkaya,A. et al. (2006) Lack of association between the MDM2-SNP309 polymorphism and breast cancer risk. Anticancer Res., 26, 4975-4977.
-
(2006)
Anticancer Res
, vol.26
, pp. 4975-4977
-
-
Petenkaya, A.1
-
22
-
-
34249982811
-
The p53 Arg72Pro and MDM2 - 309 polymorphisms and risk of breast cancer in the nurses' health studies
-
Cox,D.G. et al. (2007) The p53 Arg72Pro and MDM2 - 309 polymorphisms and risk of breast cancer in the nurses' health studies. Cancer Causes Control, 18, 621-625.
-
(2007)
Cancer Causes Control
, vol.18
, pp. 621-625
-
-
Cox, D.G.1
-
23
-
-
24944454674
-
The MDM2 promoter polymorphism SNP309T-G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck
-
Alhopuro,P. et al. (2005) The MDM2 promoter polymorphism SNP309T-G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck. J. Med. Genet., 42, 694-698.
-
(2005)
J. Med. Genet
, vol.42
, pp. 694-698
-
-
Alhopuro, P.1
-
24
-
-
33144460815
-
Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status
-
Menin,C. et al. (2006) Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status. J. Natl Cancer Inst., 98, 285-288.
-
(2006)
J. Natl Cancer Inst
, vol.98
, pp. 285-288
-
-
Menin, C.1
-
25
-
-
26444518246
-
p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome
-
Sotamaa,K. et al. (2005) p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome. Clin. Cancer Res., 11, 6840-6844.
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 6840-6844
-
-
Sotamaa, K.1
-
26
-
-
33845718248
-
MDM2 SNP309 TG alone or in combination with the TP53 R72P polymorphism does not appear to influence disease expression and age of diagnosis of colorectal cancer in HNPCC patients
-
Talseth,B.A. et al. (2007) MDM2 SNP309 TG alone or in combination with the TP53 R72P polymorphism does not appear to influence disease expression and age of diagnosis of colorectal cancer in HNPCC patients. Int. J. Cancer, 120, 563-565.
-
(2007)
Int. J. Cancer
, vol.120
, pp. 563-565
-
-
Talseth, B.A.1
-
27
-
-
33846133702
-
MDM2 SNP309 accelerates colorectal tumour formation in women
-
Bond,G.L. et al. (2006) MDM2 SNP309 accelerates colorectal tumour formation in women. J. Med. Genet., 43, 950-952.
-
(2006)
J. Med. Genet
, vol.43
, pp. 950-952
-
-
Bond, G.L.1
-
28
-
-
33846443195
-
Tumour selection advantage of non-dominant negative p53 mutations in homozygous mdm2-snp309 colorectal cancer cells
-
Alazzouzi,H. et al. (2007) Tumour selection advantage of non-dominant negative p53 mutations in homozygous mdm2-snp309 colorectal cancer cells. J. Med. Genet., 44, 75-80.
-
(2007)
J. Med. Genet
, vol.44
, pp. 75-80
-
-
Alazzouzi, H.1
-
29
-
-
33744918197
-
Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer
-
Lind,H. et al. (2006) Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer. Int. J. Cancer, 119, 718-721.
-
(2006)
Int. J. Cancer
, vol.119
, pp. 718-721
-
-
Lind, H.1
-
30
-
-
29944441900
-
Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer
-
Zhang,X. et al. (2006) Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer. Hum. Mutat., 27, 110-117.
-
(2006)
Hum. Mutat
, vol.27
, pp. 110-117
-
-
Zhang, X.1
-
31
-
-
33749546905
-
MDM2 gene promoter polymorphisms and risk of lung cancer: A case-control analysis
-
Li,G. et al. (2006) MDM2 gene promoter polymorphisms and risk of lung cancer: A case-control analysis. Carcinogenesis, 27, 2028-2033.
-
(2006)
Carcinogenesis
, vol.27
, pp. 2028-2033
-
-
Li, G.1
-
32
-
-
31844433337
-
Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population
-
Hu,Z. et al. (2006) Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population. Int. J. Cancer, 118, 1275-1278.
-
(2006)
Int. J. Cancer
, vol.118
, pp. 1275-1278
-
-
Hu, Z.1
-
33
-
-
33748038740
-
MDM2 SNP309 and SNP354 are not associated with lung cancer risk
-
Pine,S.R. et al. (2006) MDM2 SNP309 and SNP354 are not associated with lung cancer risk. Cancer Epidemiol. Biomarkers Prev., 15 1559-1561.
-
(2006)
Cancer Epidemiol. Biomarkers Prev
, vol.15
, pp. 1559-1561
-
-
Pine, S.R.1
-
34
-
-
33749040649
-
MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis
-
Ohmiya,N. et al. (2006) MDM2 promoter polymorphism is associated with both an increased susceptibility to gastric carcinoma and poor prognosis. J. Clin. Oncol., 24, 4434-4440.
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 4434-4440
-
-
Ohmiya, N.1
-
35
-
-
33750690647
-
MDM2 T309G polymorphism is associated with bladder cancer
-
Onat,O.E. et al. (2006) MDM2 T309G polymorphism is associated with bladder cancer. Anticancer Res., 26, 3473-3475.
-
(2006)
Anticancer Res
, vol.26
, pp. 3473-3475
-
-
Onat, O.E.1
-
36
-
-
27144529920
-
The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma
-
Hong,Y. et al. (2005) The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma. Cancer Res., 65 9582-9587.
-
(2005)
Cancer Res
, vol.65
, pp. 9582-9587
-
-
Hong, Y.1
-
37
-
-
33748344945
-
MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C
-
Dharel,N. et al. (2006) MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C. Clin. Cancer Res., 12, 4867-4871.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 4867-4871
-
-
Dharel, N.1
-
38
-
-
33846954399
-
Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk
-
Walsh,C.S. et al. (2007) Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk. Gynecol. Oncol., 104, 660-664.
-
(2007)
Gynecol. Oncol
, vol.104
, pp. 660-664
-
-
Walsh, C.S.1
-
39
-
-
27644571181
-
MDM2 promoter variation and age of diagnosis of acute lymphoblastic leukemia
-
Swinney,R.M. et al. (2005) MDM2 promoter variation and age of diagnosis of acute lymphoblastic leukemia. Leukemia, 19, 1996-1998.
-
(2005)
Leukemia
, vol.19
, pp. 1996-1998
-
-
Swinney, R.M.1
-
40
-
-
33751395436
-
Common polymorphism in interleukin 6 influences survival of women with ovarian and peritoneal carcinoma
-
Garg,R. et al. (2006) Common polymorphism in interleukin 6 influences survival of women with ovarian and peritoneal carcinoma. Gynecol. Oncol., 103, 793-796.
-
(2006)
Gynecol. Oncol
, vol.103
, pp. 793-796
-
-
Garg, R.1
-
41
-
-
34249103659
-
MDM2 promoter SNP309 is associated with risk of occurrence and advanced lymph node metastasis of nasopharyngeal carcinoma in Chinese population
-
Zhou,G. et al. (2007) MDM2 promoter SNP309 is associated with risk of occurrence and advanced lymph node metastasis of nasopharyngeal carcinoma in Chinese population. Clin. Cancer Res., 13, 2627-2633.
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 2627-2633
-
-
Zhou, G.1
-
42
-
-
34447542807
-
No association between MDM2 SNP309 promoter polymorphism and basal cell carcinoma of the skin
-
Wilkening,S. et al. (2007) No association between MDM2 SNP309 promoter polymorphism and basal cell carcinoma of the skin. Br J Dermatol, 157, 375-177.
-
(2007)
Br J Dermatol
, vol.157
, pp. 375-177
-
-
Wilkening, S.1
-
43
-
-
34548575637
-
Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients
-
Toyama,T. et al. (2007) Association of TP53 codon 72 polymorphism and the outcome of adjuvant therapy in breast cancer patients. Breast Cancer Res., 9, R34.
-
(2007)
Breast Cancer Res
, vol.9
-
-
Toyama, T.1
-
44
-
-
33845530151
-
The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes
-
Ruijs,M.W. et al. (2007) The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes. Eur. J. Hum. Genet., 15, 110-114.
-
(2007)
Eur. J. Hum. Genet
, vol.15
, pp. 110-114
-
-
Ruijs, M.W.1
-
45
-
-
33745235771
-
Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome
-
Bougeard,G. et al. (2006) Impact of the MDM2 SNP309 and p53 Arg72Pro polymorphism on age of tumour onset in Li-Fraumeni syndrome. J. Med. Genet., 43, 531-533.
-
(2006)
J. Med. Genet
, vol.43
, pp. 531-533
-
-
Bougeard, G.1
-
46
-
-
33749355265
-
Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer
-
Heist,R.S. et al. (2006) Matrix metalloproteinase polymorphisms and survival in stage I non-small cell lung cancer. Clin. Cancer Res. 12, 5448-5453.
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 5448-5453
-
-
Heist, R.S.1
-
47
-
-
28044453746
-
Detection of functional single-nucleotide polymorphisms that affect apoptosis
-
Harris,S.L. et al. (2005) Detection of functional single-nucleotide polymorphisms that affect apoptosis. Proc. Natl Acad. Sci. USA, 102, 16297-16302.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 16297-16302
-
-
Harris, S.L.1
-
48
-
-
33847308066
-
A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans
-
Bond,G.L. et al. (2007) A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans. Oncogene, 26, 1317-1323.
-
(2007)
Oncogene
, vol.26
, pp. 1317-1323
-
-
Bond, G.L.1
-
49
-
-
0038823932
-
The future of association studies of common cancers
-
Houlston,R.S. et al. (2003) The future of association studies of common cancers. Hum. Genet., 112, 434-435.
-
(2003)
Hum. Genet
, vol.112
, pp. 434-435
-
-
Houlston, R.S.1
-
50
-
-
0142063079
-
Polygenic inheritance of breast cancer: Implications for design of association studies
-
Antoniou,A.C. et al. (2003) Polygenic inheritance of breast cancer: Implications for design of association studies. Genet. Epidemiol., 25, 190-202.
-
(2003)
Genet. Epidemiol
, vol.25
, pp. 190-202
-
-
Antoniou, A.C.1
|