메뉴 건너뛰기




Volumn 110, Issue 40, 2013, Pages 16217-16222

Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves

Author keywords

[No Author keywords available]

Indexed keywords

7,8 DIHYDROXYFLAVONE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BRAIN DERIVED NEUROTROPHIC FACTOR; DEOXYGEDUNIN; UNCLASSIFIED DRUG;

EID: 84885038440     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303646110     Document Type: Article
Times cited : (85)

References (33)
  • 1
    • 0032413178 scopus 로고    scopus 로고
    • Schwann cells, neurotrophic factors, and peripheral nerve regeneration
    • Frostick SP, Yin Q, Kemp GJ (1998) Schwann cells, neurotrophic factors, and peripheral nerve regeneration. Microsurgery 18(7):397-405.
    • (1998) Microsurgery , vol.18 , Issue.7 , pp. 397-405
    • Frostick, S.P.1    Yin, Q.2    Kemp, G.J.3
  • 2
    • 70049086067 scopus 로고    scopus 로고
    • Peripheral nerve injuries: An international survey of current treatments and future perspectives
    • Scholz T, et al. (2009) Peripheral nerve injuries: An international survey of current treatments and future perspectives. J Reconstr Microsurg 25(6):339-344.
    • (2009) J Reconstr Microsurg , vol.25 , Issue.6 , pp. 339-344
    • Scholz, T.1
  • 3
    • 80555148692 scopus 로고    scopus 로고
    • Oxford Univ Press, New York, p 463
    • Brushart TM (2011) Nerve Repair (Oxford Univ Press, New York), p 463.
    • (2011) Nerve Repair
    • Brushart, T.M.1
  • 4
    • 0034175684 scopus 로고    scopus 로고
    • Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration
    • Al-Majed AA, Neumann CM, Brushart TM, Gordon T (2000) Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci 20(7):2602-2608.
    • (2000) J Neurosci , vol.20 , Issue.7 , pp. 2602-2608
    • Al-Majed, A.A.1    Neumann, C.M.2    Brushart, T.M.3    Gordon, T.4
  • 5
    • 20644434062 scopus 로고    scopus 로고
    • Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation
    • Groves ML, et al. (2005) Axon regeneration in peripheral nerves is enhanced by proteoglycan degradation. Exp Neurol 195(2):278-292.
    • (2005) Exp Neurol , vol.195 , Issue.2 , pp. 278-292
    • Groves, M.L.1
  • 6
    • 0036144945 scopus 로고    scopus 로고
    • A decline in glial cell-linederived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation
    • Höke A, Gordon T, Zochodne DW, Sulaiman OA (2002) A decline in glial cell-linederived neurotrophic factor expression is associated with impaired regeneration after long-term Schwann cell denervation. Exp Neurol 173(1):77-85.
    • (2002) Exp Neurol , vol.173 , Issue.1 , pp. 77-85
    • Höke, A.1    Gordon, T.2    Zochodne, D.W.3    Sulaiman, O.A.4
  • 7
    • 0031063473 scopus 로고    scopus 로고
    • The cellular and molecular basis of peripheral nerve regeneration
    • Fu SY, Gordon T (1997) The cellular and molecular basis of peripheral nerve regeneration. Mol Neurobiol 14(1-2):67-116.
    • (1997) Mol Neurobiol , vol.14 , Issue.1-2 , pp. 67-116
    • Fu, S.Y.1    Gordon, T.2
  • 8
    • 0027360908 scopus 로고
    • Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve
    • Funakoshi H, et al. (1993) Differential expression of mRNAs for neurotrophins and their receptors after axotomy of the sciatic nerve. J Cell Biol 123(2):455-465.
    • (1993) J Cell Biol , vol.123 , Issue.2 , pp. 455-465
    • Funakoshi, H.1
  • 9
    • 84859340829 scopus 로고    scopus 로고
    • Cooperative roles of BDNF expression in neurons and Schwann cells aremodulated by exercise to facilitate nerve regeneration
    • Wilhelm JC, et al. (2012) Cooperative roles of BDNF expression in neurons and Schwann cells aremodulated by exercise to facilitate nerve regeneration. J Neurosci 32(14): 5002-5009.
    • (2012) J Neurosci , vol.32 , Issue.14 , pp. 5002-5009
    • Wilhelm, J.C.1
  • 10
    • 0034507954 scopus 로고    scopus 로고
    • Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents
    • Zhang JY, Luo XG, Xian CJ, Liu ZH, Zhou XF (2000) Endogenous BDNF is required for myelination and regeneration of injured sciatic nerve in rodents. Eur J Neurosci 12(12):4171-4180.
    • (2000) Eur J Neurosci , vol.12 , Issue.12 , pp. 4171-4180
    • Zhang, J.Y.1    Luo, X.G.2    Xian, C.J.3    Zh, L.4    Zhou, X.F.5
  • 11
    • 20644438664 scopus 로고    scopus 로고
    • Neurotrophin-4/5 is required for the early growth of regenerating axons in peripheral nerves
    • English AW, Meador W, Carrasco DI (2005) Neurotrophin-4/5 is required for the early growth of regenerating axons in peripheral nerves. Eur J Neurosci 21(10):2624-2634.
    • (2005) Eur J Neurosci , vol.21 , Issue.10 , pp. 2624-2634
    • English, A.W.1    Meador, W.2    Carrasco, D.I.3
  • 12
    • 0029928170 scopus 로고    scopus 로고
    • Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF
    • Poduslo JF, Curran GL (1996) Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. Brain Res Mol Brain Res 36(2):280-286.
    • (1996) Brain Res Mol Brain Res , vol.36 , Issue.2 , pp. 280-286
    • Poduslo, J.F.1    Curran, G.L.2
  • 13
    • 0035901738 scopus 로고    scopus 로고
    • Analysis of effects and pharmacokinetics of subcutaneously administered BDNF
    • Kishino A, et al. (2001) Analysis of effects and pharmacokinetics of subcutaneously administered BDNF. Neuroreport 12(5):1067-1072.
    • (2001) Neuroreport , vol.12 , Issue.5 , pp. 1067-1072
    • Kishino, A.1
  • 14
    • 70350346602 scopus 로고    scopus 로고
    • PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution
    • Soderquist RG, et al. (2009) PEGylation of brain-derived neurotrophic factor for preserved biological activity and enhanced spinal cord distribution. J Biomed Mater Res A 91(3):719-729.
    • (2009) J Biomed Mater Res A , vol.91 , Issue.3 , pp. 719-729
    • Soderquist, R.G.1
  • 15
    • 0031027332 scopus 로고    scopus 로고
    • Adult mammalian sensory and motor neurons: Roles of endogenous neurotrophins and rescue by exogenous neurotrophins after axotomy
    • Munson JB, Shelton DL, McMahon SB (1997) Adult mammalian sensory and motor neurons: Roles of endogenous neurotrophins and rescue by exogenous neurotrophins after axotomy. J Neurosci 17(1):470-476.
    • (1997) J Neurosci , vol.17 , Issue.1 , pp. 470-476
    • Munson, J.B.1    Shelton, D.L.2    McMahon, S.B.3
  • 16
    • 0036829006 scopus 로고    scopus 로고
    • Neurotrophins: From enthusiastic expectations through sobering experiences to rational therapeutic approaches
    • Thoenen H, Sendtner M (2002) Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches. Nat Neurosci 5(Suppl): 1046-1050.
    • (2002) Nat Neurosci , vol.5 , Issue.SUPPL. , pp. 1046-1050
    • Thoenen, H.1    Sendtner, M.2
  • 17
    • 77249168715 scopus 로고    scopus 로고
    • A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone
    • Jang SW, et al. (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc Natl Acad Sci USA 107(6):2687-2692.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.6 , pp. 2687-2692
    • Jang, S.W.1
  • 18
    • 77955351134 scopus 로고    scopus 로고
    • Deoxygedunin, a natural product with potent neurotrophic activity in mice
    • Jang SW, et al. (2010) Deoxygedunin, a natural product with potent neurotrophic activity in mice. PLoS ONE 5(7):e11528.
    • (2010) PLoS ONE , vol.5 , Issue.7
    • Jang, S.W.1
  • 19
    • 84863185677 scopus 로고    scopus 로고
    • Fear extinction and BDNF: Translating animal models of PTSD to the clinic
    • Andero R, Ressler KJ (2012) Fear extinction and BDNF: Translating animal models of PTSD to the clinic. Genes Brain Behav 11(5):503-512.
    • (2012) Genes Brain Behav , vol.11 , Issue.5 , pp. 503-512
    • Andero, R.1    Ressler, K.J.2
  • 20
    • 78649857797 scopus 로고    scopus 로고
    • A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect
    • Liu X, et al. (2010) A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. J Med Chem 53:8274-8286.
    • (2010) J Med Chem , vol.53 , pp. 8274-8286
    • Liu, X.1
  • 21
    • 84871799000 scopus 로고    scopus 로고
    • Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning
    • Choi DC, Gourley SL, Ressler KJ (2012) Prelimbic BDNF and TrkB signaling regulates consolidation of both appetitive and aversive emotional learning. Transcult Psychiatry 2:e205.
    • (2012) Transcult Psychiatry , vol.2
    • Choi, D.C.1    Gourley, S.L.2    Ressler, K.J.3
  • 22
    • 84856059838 scopus 로고    scopus 로고
    • 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease
    • Devi L, Ohno M (2012) 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology 37(2):434-444.
    • (2012) Neuropsychopharmacology , vol.37 , Issue.2 , pp. 434-444
    • Devi, L.1    Ohno, M.2
  • 23
    • 84871948613 scopus 로고    scopus 로고
    • Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress
    • Gupta VK, You Y, Li JC, Klistorner A, Graham SL (2013) Protective effects of 7,8-dihydroxyflavone on retinal ganglion and RGC-5 cells against excitotoxic and oxidative stress. J Mol Neurosci 49(1):96-104.
    • (2013) J Mol Neurosci , vol.49 , Issue.1 , pp. 96-104
    • Gupta, V.K.1    You, Y.2    Li, J.C.3    Klistorner, A.4    Graham, S.L.5
  • 24
    • 80052563683 scopus 로고    scopus 로고
    • Vulnerability to depression: From brain neuroplasticity to identification of biomarkers
    • Blugeot A, et al. (2011) Vulnerability to depression: From brain neuroplasticity to identification of biomarkers. J Neurosci 31(36):12889-12899.
    • (2011) J Neurosci , vol.31 , Issue.36 , pp. 12889-12899
    • Blugeot, A.1
  • 25
    • 84867352628 scopus 로고    scopus 로고
    • Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression
    • Liu X, et al. (2012) Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. J Med Chem55(19):8524-8537.
    • (2012) J Med Chem , vol.55 , Issue.19 , pp. 8524-8537
    • Liu, X.1
  • 26
    • 84855836040 scopus 로고    scopus 로고
    • The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission
    • Mantilla CB, Ermilov LG (2012) The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. Muscle Nerve 45(2):274-276.
    • (2012) Muscle Nerve , vol.45 , Issue.2 , pp. 274-276
    • Mantilla, C.B.1    Ermilov, L.G.2
  • 27
    • 83055185674 scopus 로고    scopus 로고
    • Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging
    • Zeng Y, et al. (2011) Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. J Neurosci 31(49):17800-17810.
    • (2011) J Neurosci , vol.31 , Issue.49 , pp. 17800-17810
    • Zeng, Y.1
  • 28
    • 70349744369 scopus 로고    scopus 로고
    • The role of neurotrophic factors in nerve regeneration
    • Gordon T (2009) The role of neurotrophic factors in nerve regeneration. Neurosurg Focus 26(2):E3.
    • (2009) Neurosurg Focus , vol.26 , Issue.2
    • Gordon, T.1
  • 29
    • 0034509612 scopus 로고    scopus 로고
    • Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons
    • Al-Majed AA, Brushart TM, Gordon T (2000) Electrical stimulation accelerates and increases expression of BDNF and trkB mRNA in regenerating rat femoral motoneurons. Eur J Neurosci 12(12):4381-4390.
    • (2000) Eur J Neurosci , vol.12 , Issue.12 , pp. 4381-4390
    • Al-Majed, A.A.1    Brushart, T.M.2    Gordon, T.3
  • 30
    • 43449106180 scopus 로고    scopus 로고
    • Treadmill training promotes axon regeneration in injured peripheral nerves
    • Sabatier MJ, Redmon N, Schwartz G, English AW (2008) Treadmill training promotes axon regeneration in injured peripheral nerves. Exp Neurol 211(2):489-493.
    • (2008) Exp Neurol , vol.211 , Issue.2 , pp. 489-493
    • Sabatier, M.J.1    Redmon, N.2    Schwartz, G.3    English, A.W.4
  • 31
    • 34548621444 scopus 로고    scopus 로고
    • Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotrophin signaling
    • English AW, Schwartz G, Meador W, Sabatier MJ, Mulligan A (2007) Electrical stimulation promotes peripheral axon regeneration by enhanced neuronal neurotrophin signaling. Dev Neurobiol 67(2):158-172.
    • (2007) Dev Neurobiol , vol.67 , Issue.2 , pp. 158-172
    • English, A.W.1    Schwartz, G.2    Meador, W.3    Sabatier, M.J.4    Mulligan, A.5
  • 32
    • 0344394198 scopus 로고    scopus 로고
    • Fibrin sealants and glues
    • MacGillivray TE (2003) Fibrin sealants and glues. J Card Surg 18(6):480-485.
    • (2003) J Card Surg , vol.18 , Issue.6 , pp. 480-485
    • Macgillivray, T.E.1
  • 33
    • 0033634813 scopus 로고    scopus 로고
    • Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    • Feng G, et al. (2000) Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28(1):41-51.
    • (2000) Neuron , vol.28 , Issue.1 , pp. 41-51
    • Feng, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.