Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: Contributions of NOS isoforms to blood pressure and heart rate control

Cardiovascular Research

Volumn 42, Issue 1, 1999, Pages 206-213

  Kojda, Georg ^a,b   Laursen, Jorn B ^a   Ramasamy, Santhini ^a   Kent, Jonathan D ^a   Kurz, Sabine ^a   Burchfield, Jana ^a   Shesely, Edward G ^c   Harrison, David G ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c NONE

Author keywords

Blood pressure; Endothelial nitric oxide synthase; Gene disruption; Heart rate; Nitroglycerin; Phenylephrine; Serotonine; Soluble guanylate cyclase

Indexed keywords

CALCIMYCIN; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; ENZYME ACTIVITY; ENZYME LOCALIZATION; HEART RATE VARIABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; BLOTTING, WESTERN; ENZYME INHIBITORS; GENE DELETION; GENE EXPRESSION; GUANYLATE CYCLASE; HEART RATE; HEMODYNAMIC PROCESSES; HETEROZYGOTE; HYPERTENSION; ISOENZYMES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; VASOCONSTRICTION;

EID: 0032897665     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(98)00315-0     Document Type: Article

References (25)

1. Nathan C., Xie Q. Nitric oxide synthases: Roles, tolls, and controls. Cell. 78:1994;915-918.
2. Moncada S., Higgs A. Mechanisms of disease: The L-arginine-nitric oxide pathway. N Engl J Med. 329:1993;2002-2012.
3. Radomski M.W., Moncada S. Regulation of vascular hemostasis by nitric oxide. Thromb Haemost. 70:1993;36-41.
4. Buga G.M., Gold M.E., Fukuto J.M., Ignarro L.J. Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension. 17:1991;187-193.
5. Pohl U., Holtz J., Busse R., Bassenge E. Crucial role of endothelium in the vascular response to increased flow in vivo. Hypertension. 8:1986;37-44.
6. Rubanyi G.M., Romero J.C., Vanhoutte P.M. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol Heart Circ Physiol. 250:1986;H1145-H1149.
7. Togashi H., Sakuma I., Yoshioka M.et al. A central nervous system action of nitric oxide in blood pressure regulation. J Pharmacol Exp Ther. 262:1992;343-347.
8. G-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sypathetic tone? Circ Res. 70:1992;607-611.
9. Shudo H. Studies on the role of L-arginine to nitric oxide-pathway for the cardiovascular control assesment with a new model of hypertension produced by the chronic administration of nitric oxide synthase inhibitor. Hokkaido-Igaku Zasshi. 69:1994;967-977.
10. Huang P.L., Huang Z.H., Mashimo H.et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 377:1995;239-242.
11. Shesely E.G., Maeda N., Kim H.S.et al. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proc Natl Acad Sci USA. 93:1996;13176-13181.
12. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:1976;248-254.
13. Arnal J.-F., Yamin J., Dockery S., Harrison D.G. Regulation of endothelial nitric oxide synthase mRNA, protein, and activity during cell growth. Am J Physiol Cell Physiol. 267(36):1994;C1381-C1388.
14. Schultz G, Böhme E. Guanylate cyclase. In: Bergmeyer HU, editor. Methods of enzymatic analysis. Weinheim, FRG: Verlag Chemie, 1984, pp. 379-389.
15. Freiman P.C., Mitchell G.G., Heistad D.D., Armstrong M.L., Harrison D.G. Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ Res. 58:1986;783-789.
16. Krege J.H., Hodgin J.B., Hagaman J.R., Smithies O. A noninvasive computerized tail cuff system for measuring blood pressure in mice. Hypertension. 25:1995;1111-1115.
17. Hafner D., Heinen E., Noack E. Mathematical analysis of concentration-response-relationships. Arzneim Forsch. 27:1977;1871-1873.
18. G-nitro-L-arginine. Br J Pharmacol. 118:1996;1433-1440.
19. Kurihara N, Alfie M, Sigmon D, Shesely EG, Carretero O. Endothelial nitric oxide synthase knockout mice (eNOS-KO): Effects of N-omega-nitro-L-arginine methylester (L-NAME) on blood pressure. Abstract presented at the XIIth Meeting of the American Society of Hypertension, March 15-18, 1997.
20. f. Circ Res. 81:1997;60-68.
21. Chapleau M.W., Cunningham J.T., Sullivan M.J., Wachtel R.E., Abboud F.M. Structural versus functional modulation of the arterial baroreflex. Hypertension. 26:1995;341-347.
22. Alheid U., Dudel C., Förstermann U. Selective inhibition by gossypol of endothelium-dependent relaxations augments relaxations to glyceryl trinitrate. Br J Pharmacol. 92(1):1987;327-340.
23. Moncada S., Rees D.D., Schulz R., Palmer R.M.J. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo. Proc Natl Acad Sci USA. 88:1991;2166-2170.
24. Kojda G., Patzner M., Hacker A., Noack E. Nitric oxide inhibits vascular bioactivation of glyceryl trinitrate. A novel mechanism to explain preferential venodilation of organic nitrates. Mol Pharmacol. 53:1998;545-547.
25. Wang G.R., Zhu Y., Halushka P.V., Lincoln T.M., Mendelsohn M.E. Mechanism of platelet inhibition by nitric oxide: in vivo phosphorylation of thromboxane receptor by cyclic GMP-dependent protein kinase. Proc Natl Acad Sci USA. 95(9):1998;4888-4893.