IL-1 trap rilonacept in refractory adult onset Still's disease

Annals of the Rheumatic Diseases

Volumn 71, Issue 12, 2012, Pages 2056-2057

  Petryna, Olga ^a   Jack Cush, J ^b   Efthimiou, Petros ^c  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

^c LINCOLN MEDICAL AND MENTAL HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; AZATHIOPRINE; FERRITIN; INTERLEUKIN 1; LEFLUNOMIDE; METHOTREXATE; PREDNISONE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RILONACEPT;

ADULT; ADULT ONSET STILL DISEASE; BINDING AFFINITY; CASE REPORT; CINCA SYNDROME; CLINICAL FEATURE; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG APPROVAL; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG PROTEIN BINDING; DRUG SUBSTITUTION; DRUG TREATMENT FAILURE; DRUG WITHDRAWAL; FEMALE; HUMAN; HYPERFERRITINEMIA; LETTER; LOADING DRUG DOSE; LUNG FUNCTION TEST; MAINTENANCE DRUG DOSE; MEDICAL HISTORY; PRIORITY JOURNAL; TREATMENT DURATION;

ADULT; DRUG RESISTANCE; FEMALE; HUMANS; INTERLEUKIN-1; RECOMBINANT FUSION PROTEINS; STILL'S DISEASE, ADULT-ONSET; TREATMENT OUTCOME;

EID: 84868471554     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-201409     Document Type: Letter

References (6)

1. Efthimiou P, Paik PK, Bielory L. Diagnosis and management of adult onset Still's disease. Ann Rheum Dis 2006;65:564-72.
2. Dinarello CA. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 2011;117:3720-32.
3. Dubois EA, Rissmann R, Cohen AF. Rilonacept and canakinumab. Br J Clin Pharmacol 2011;71:639-41.
4. Lequerré T, Quartier P, Rosellini D, et al. Interleukin-1 receptor antagonist (anakinra) treatment in patients with systemic-onset juvenile idiopathic arthritis or adult onset Still disease: preliminary experience in France. Ann Rheum Dis 2008;67:302-8.
5. Laskari K, Tzioufas AG, Moutsopoulos HM. Efficacy and long-term follow-up of IL-1R inhibitor anakinra in adults with Still's disease: a case-series study. Arthritis Res Ther 2011;13:R91.
6. Gillespie J, Mathews R, McDermott MF. Rilonacept in the management of cryopyrin-associated periodic syndromes (CAPS). J Inflamm Res 2010;3:1-8.